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Structure–function relationship of the TRP channel superfamily

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Book cover Reviews of Physiology, Biochemistry and Pharmacology

Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology ((REVIEWS,volume 156))

Abstract

Transient receptor potential (TRP) channels are involved in the perception of a wide range of physical and chemical stimuli, including temperature and osmolarity changes, light, pain, touch, taste and pheromones, and in the initiation of cellular responses thereupon. Since the last decade, rapid progress has been made in the identification and characterization of new members of the TRP superfamily. They constitute a large superfamily of cation channels that are expressed in almost all cell types in both invertebrates and vertebrates. This review summarizes and discusses the current knowledge on the TRP protein structure and its impact on the regulation of the channel function.

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Acknowledgements

We thank Drs. Karel Talavera, Joris Vriens, and Frank Mahieu for helpful discussions. This work was supported by the Human Frontiers Science Programme (HFSP Research Grant Ref. RGP 32/2004), the Belgian Federal Government, the Flemish Government, the Onderzoeksraad KU Leuven (GOA 2004/07, F.W.O. G.0214.99, F.W.O. G. 0136.00, F.W.O. G.0172.03, Interuniversity Poles of Attraction Program, Prime Ministers Office IUAP).

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  1. Laboratorium voor Fysiologie, Katholieke Universiteit Leuven, Herestraat 49, 3000, Leuven, Belgium

    G. Owsianik, D. D'hoedt, T. Voets & B. Nilius

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  1. G. Owsianik
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  2. D. D'hoedt
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  3. T. Voets
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  4. B. Nilius
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Correspondence to B. Nilius .

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Owsianik, G., D'hoedt, D., Voets, T., Nilius, B. (2006). Structure–function relationship of the TRP channel superfamily. In: Amara, S., et al. Reviews of Physiology, Biochemistry and Pharmacology. Reviews of Physiology, Biochemistry and Pharmacology, vol 156. Springer, Berlin, Heidelberg. https://doi.org/10.1007/s10254-005-0006-0

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