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Regulation of peptide bond cis/trans isomerization by enzyme catalysis and its implication in physiological processes

  • G. FischerEmail author
  • T. Aumüller
Part of the Reviews of Physiology, Biochemistry and Pharmacology book series (REVIEWS, volume 148)

Abstract

In some cases, the slow rotational movement underlying peptide bond cis/trans isomerizations is found to control the biological activity of proteins. Peptide bond cis/trans isomerases as cyclophilins, Fk506-binding proteins, parvulins, and bacterial hsp70 generally assist in the interconversion of the polypeptide substrate cis/trans isomers, and rate acceleration is the dominating mechanism of action in cells. We present evidence disputing the hypothesis that some of the molecular properties of these proteins play an auxiliary role in enzyme function.

Keywords

Peptide Bond Trigger Factor FK506 Binding Protein Peptidyl Prolyl Isomerase PPIase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag 2003

Authors and Affiliations

  1. 1.Max Planck Research Unit for Enzymology of Protein FoldingHalleGermany

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