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The components of the proteasome system and their role in MHC class I antigen processing

  • E. Krüger
  • U. Kuckelkorn
  • A. Sijts
  • P.-M. KloetzelEmail author
Chapter
Part of the Reviews of Physiology, Biochemistry and Pharmacology book series (REVIEWS, volume 148)

Abstract

By generating peptides from intracellular antigens which are then presented to T cells, the ubiquitin/26S proteasome system plays a central role in the cellular immune response. The proteolytic properties of the proteasome are adapted to the requirements of the immune system by proteasome components whose synthesis is under the control of interferon-γ. Among these are three subunits with catalytic sites that are incorporated into the enzyme complex during its de novo synthesis. Thus, the proteasome assembly pathway and the formation of immunoproteasomes play a critical regulatory role in the regulation of the proteasome’s catalytic properties. In addition, interferon-α also induces the synthesis of the proteasome activator PA28 which, as part of the so-called hybrid proteasome, exerts a more selective function in antigen presentation. Consequently, the combination of a number of regulatory events tunes the proteasome system to gain maximal efficiency in the generation of peptides with regard to their quality and quantity.

Keywords

Major Histocompatibility Complex Class Human Papilloma Virus Antigen Processing Proteasome System Central Gate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • E. Krüger
    • 1
  • U. Kuckelkorn
    • 1
  • A. Sijts
    • 1
  • P.-M. Kloetzel
    • 1
    Email author
  1. 1.Institut für Biochemie, Medizinesche FakultätHumboldt-Universität zu BerlinBerlinGermany

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