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Molecular mechanisms in clathrin-mediated membrane budding

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Book cover Regulatory Mechanisms of Intracellular Membrane Transport

Part of the book series: Topics in Current Genetics ((TCG,volume 10))

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Abstract

Clathrin-coated vesicles (CCVs) form at the plasma membrane where they select cargo for endocytic entry into cells. CCVs also form at the trans-Golgi network (TGN) where they function in protein transport from the secretory pathway to the endosomal/lysosomal system. It has been long thought that clathrin and the clathrin adaptors 1 (AP-1) and 2 (AP-2) could define a minimal machinery for the formation of CCVs and the selection of cargo. However, it is now clear that although clathrin, AP-1 and AP-2 are key components of these processes, complex protein machineries are necessary to regulate many of the fundamental processes in CCV formation and cargo selection at both the plasma membrane and the TGN.

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  1. Montreal Neurological Institute, McGill University, 3801 University, Montreal, QC, H3A 2B4, Canada

    Brigitte Ritter & Peter S. McPherson

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  1. Brigitte Ritter
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  2. Peter S. McPherson
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Sirkka Keränen Jussi Jäntti

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Ritter, B., McPherson, P.S. Molecular mechanisms in clathrin-mediated membrane budding. In: Keränen, S., Jäntti, J. (eds) Regulatory Mechanisms of Intracellular Membrane Transport. Topics in Current Genetics, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/b98564

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  • DOI: https://doi.org/10.1007/b98564

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  • Print ISBN: 978-3-540-22302-3

  • Online ISBN: 978-3-540-44476-3

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