Abstract
A novel diblock copolymer, consisting of a biocompatible phosphorylcholine block (MPC) and a pH sensitive dimethylamino ethyl block (DMA), denoted as MPC30DMA60, shows interesting properties of surface adsorption and solution aggregation. These features have been exploited to condense DNA into nanoaggregates in bulk solution and to immobilise DNA onto a substrate surface. These molecular manipulations may find their applications in controlled release and bionanotechnology.
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Acknowledgements: We thank Biocompatibles UK Ltd., for financial support to Q.S.M. We also thank EPSRC for the support of the neutron experiments.
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© 2004 Springer-Verlag
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Mu, Q.S., Ma, Y.H., Lewis, A.L., Armes, S.P., Lu, J.R. (2004). Complexation of DNA with biocompatible diblock copolymers. In: Surface and Colloid Science. Progress in Colloid and Polymer Science, vol 128. Springer, Berlin, Heidelberg. https://doi.org/10.1007/b97072
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DOI: https://doi.org/10.1007/b97072
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Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-21247-8
Online ISBN: 978-3-540-39980-3
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