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Transcriptional regulation of intestinal nutrient transporters

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Molecular Mechanisms Controlling Transmembrane Transport

Part of the book series: Topics in Current Genetics ((TCG,volume 9))

Abstract

Nutrient transport across the apical plasma membrane of enterocytes is mediated by highly specialised membrane proteins, the majority of which are adaptively regulated by dietary substrates. The nutrient signals are either transmitted by the transporter itself, regulating the external nutrient access to the intracellular environment, or via distinct luminal membrane nutrient sensors. This chapter addresses the importance of the transcriptional regulation of intestinal nutrient transporter genes, and highlights its relevance to nutrition, health and disease. Examples are given of nutrient transporters from both the small and large intestine for which the underlying transcriptional mechanisms have been identified. These include the Na+/glucose cotransporter (SGLT1) and the bile salt transporter (ABST) expressed in the small intestine, and the monocarboxylate transporter (MCT1), residing in the large intestine. A better understanding of transcriptional regulation of intestinal nutrient transporters will undoubtedly have important clinical and nutritional implications.

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  1. Epithelial Function and Development Group, Department of Veterinary Preclinical Sciences, The University of Liverpool, Brownlow Hill, Liverpool L69 7ZJ, UK

    Soraya P. Shirazi-Beechey

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Shirazi-Beechey, S.P. (2004). Transcriptional regulation of intestinal nutrient transporters. In: Molecular Mechanisms Controlling Transmembrane Transport. Topics in Current Genetics, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/b96814

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  • DOI: https://doi.org/10.1007/b96814

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