Palladium-Catalyzed Cross-Coupling Reactions in the Synthesis of Pharmaceuticals

Abstract

The use of Pd-catalyzed cross-coupling methods for the construction of C-C, C-N, and C-O bonds have increased exponentially over the years. The variety of mild and chemoselective coupling conditions available make these coupling protocols very desirable for the preparation of compounds with highly functionalized and complex molecular structures. Pharmaceutical companies have used these methods for preparing new drug candidates on a small scale as well as the manufacturing of approved drug substances on a commercial scale. In this chapter we will focus our attention mainly on the application of these coupling methods in relatively large-scale pharmaceutical applications.