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Protein Kinases Involved in Mitotic Spindle Checkpoint Regulation

  • Ingrid HoffmannEmail author
Chapter
Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 42)

Abstract

A number of checkpoint controls function to preserve the genome by restraining cell cycle progression until prerequisite events have been properly completed. Chromosome attachment to the mitotic spindle is monitored by the spindle assembly checkpoint. Sister chromatid separation in anaphase is initiated only once all chromosomes have been attached to both poles of the spindle. Premature separation of sister chromatids leads to the loss or gain of chromosomes in daughter cells (aneuploidy), a prevalent form of genetic instability of human cancer. The spindle assembly checkpoint ensures that cells with misaligned chromosomes do not exit mitosis and divide to form aneuploid cells. A number of protein kinases and checkpoint phosphoproteins are required for the function of the spindle assembly checkpoint. This review discusses the recent progress in understanding the role of protein kinases of the mitotic checkpoint complex in the surveillance pathway of the checkpoint.

Keywords

Spindle Assembly Checkpoint Mitotic Arrest Spindle Checkpoint Mitotic Checkpoint Checkpoint Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Notes

Acknowledgments

I thank my coworkers Onur Cizmecioglu and Daniel Spengler for discussions and critical reading of the manuscript.

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Authors and Affiliations

  1. 1.Cell Cycle Control and Carcinogenesis (F045)German Cancer Research Center (DKFZ)HeidelbergGermany

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