Interface Tissue Engineeringand the Formulation of Multiple-Tissue Systems

Chapter
Part of the Advances in Biochemical Engineering/Biotechnology book series (ABE, volume 102)

Abstract

Interface tissue engineering is an exciting field which focuses on the development of tissue engineered grafts capable of promoting integration between different types of tissue and between the implant and surrounding tissue. Focusing on interface tissue engineering, and using the insertion site between the anterior cruciate ligament and bone as an example, this chapter discusses strategies in soft tissue to bone integration as well as current tissue engineering efforts in this area. This review begins with the clinical significance of this problem, followed by a review of existing fixation methods, and tissue engineering efforts aimed at addressing this critical issue. The development of multi-phased scaffolds designed for the replacement of more than one type of tissue, as well as novel in vitro co-culture systems will be introduced. Future directions in the field of interface tissue engineering will also be discussed.

Co-culture Interface tissue engineering Ligament--bone insertion Scaffolds 

Abbreviations

3-D

Three-dimensional

ACL

Anterior crucial ligament

BG

45S5 bioactive glass

hBMSCs

Human bone marrow stromal cells

GAG

Glycosaminoglycan

PLAGA

Poly(lactide-co-glycolide)

SEM

Scanning electron microscopy

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Notes

Acknowledgments

The authors would like to acknowledge funding support from the Whitaker Foundation and the National Institutes of Health.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  1. 1.Department of Biomedical EngineeringFu Foundation School of Engineering and Applied Science, Columbia UniversityNew YorkUSA

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