Cell Instructive Polymers

Chapter
Part of the Advances in Biochemical Engineering/Biotechnology book series (ABE, volume 102)

Abstract

Polymeric materials used in tissue engineering were initially used solely as delivery vehicles for transplanting cells. However, these materials are currently designed to actively regulate the resultant tissue structure and function. This control is achieved through spatial and temporal regulation of various cues (e.g., adhesion ligands, growth factors) provided to interacting cells from the material. These polymeric materials that control cell function and tissue formation are termed cell instructive polymers, and recent trends in their design are outlined in this chapter.

Cells External stimuli Growth factors Synthetic extracellular matrix  

Abbreviations

BMP

bone morphogenetic protein

CAD/CAM

computer-aided design/computer-aided manufacturing

CT

computer tomography

DDS

drug delivery system

ECM

extracellular matrix

EGF

epidermal growth factor

FDM

fused deposition molding

FGF

fibroblast growth factor

G

α-L-guluronic acid

GAG

glycosaminoglycan

HB-EGF

heparin-binding epidermal growth factor

HGF

hepatocyte growth factor

IGF

insulin-like growth factor

M

β-D-mannuronic acid

MRI

magnetic resonance imaging

mRNA

messenger RNA

PDGF

platelet-derived growth factor

PDGF-BB

platelet derived growth factor-BB

PEG

polyethylene glycol

PEO

polyethylene oxide

PET

polyethylene terephthalate

PGA

polyglycolic acid

PGCL

poly(glycolide-co-caprolactone)

PHEMA

poly(2-hydroxyethylmethacrylate)

PLA

poly lactic acid

PLG

poly(lactic acid-co-glycolic acid)

PNIPAAm

poly(N-isopropylacrylamide-co-acrylamide)

PVA

polyvinyl alcohol

SCID mice

severe combined immuno-deficiency mice

SFF

solid free-form fabrication

TGF-β

transforming growth factor-β

TRAP

tartrate-resistant acid phosphatase

VCAM-1

vascular cell adhesion molecule-1

VEGF

vascular endothelial growth factor

3D

three-dimensional

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Copyright information

© Springer-Verlag Berlin Heidelberg 2005

Authors and Affiliations

  1. 1.Division of Engineering and Applied SciencesHarvard UniversityCambridgeUSA

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