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Review: Biodegradable Polymeric Scaffolds. Improvements in Bone Tissue Engineering through Controlled Drug Delivery

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Tissue Engineering I

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 102))

Abstract

Recent advances in biology, medicine, and engineering have led to the discovery of new therapeutic agents and novel materials for the repair of large bone defects caused by trauma, congenital defects, or bone tumors. These repair strategies often utilize degradable polymeric scaffolds for the controlled localized delivery of bioactive molecules to stimulate bone ingrowth as the scaffold degrades. Polymer composition, hydrophobicity, crystallinity, and degradability will affect the rate of drug release from these scaffolds, as well as the rate of tissue ingrowth. Accordingly, this chapter examines the wide range of synthetic degradable polymers utilized for osteogenic drug delivery. Additionally, the therapeutic proteins involved in bone formation and in the stimulation of osteoblasts, osteoclasts, and progenitor cells are reviewed to direct attention to the many critical issues influencing effective scaffold design for bone repair.

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Abbreviations

bFGF:

Basic fibroblastic growth factor

BMP:

Bone morphogenetic protein

BSA:

Bovine serum albumin

IGF-1:

Insulin-like growth factor-1

OPF:

Oligo(poly(ethylene glycol) fumarate)

PCL:

Poly(ε-caprolactone)

PCPP-SA:

Poly(carboxyphenoxy propane--sebacic acid)

PDGF:

Platelet-derived growth factor

PEG:

Poly(ethylene glycol)

PGA:

Poly(glycolic acid)

PLA:

Poly(d,l-lactic acid)

PLGA:

Poly(lactic-co-glycolic acid)

PLLA:

Poly(l-lactic acid)

PMMA:

Poly(methyl methacrylate)

PPF:

Poly(propylene fumarate)

rh:

Recombinant human

ST-NH-PEG x -PLA y :

N-succinimidyl tartrate monoamine poly(ethylene glycol)--poly(d,l-lactic acid)

TGF-β1:

Transforming growth factor-β1

VEGF:

Vascular endothelial growth factor

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Acknowledgments

The work on drug delivery for bone tissue engineering was supported by the National Institutes of Health (R01 AR48756). T.A.H. also acknowledges financial support from a Whitaker Foundation Graduate Fellowship.

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  1. Department of Bioengineering, Rice University, P.O. Box 1892, MS 142, TX 77251-1892, Houston, USA

    Theresa A. Holland & Antonios G. Mikos

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  1. Theresa A. Holland
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  2. Antonios G. Mikos
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Correspondence to Antonios G. Mikos .

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Kyongbum Lee David Kaplan

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Holland, T.A., Mikos, A.G. (2005). Review: Biodegradable Polymeric Scaffolds. Improvements in Bone Tissue Engineering through Controlled Drug Delivery. In: Lee, K., Kaplan, D. (eds) Tissue Engineering I. Advances in Biochemical Engineering/Biotechnology, vol 102. Springer, Berlin, Heidelberg . https://doi.org/10.1007/b137205

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