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Systems biology of the yeast cell cycle engine

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Systems Biology

Part of the book series: Topics in Current Genetics ((TCG,volume 13))

Abstract

One goal of systems biology is to obtain an integrated understanding of the physiological properties of cells from the detailed molecular machinery (the genes, proteins, and metabolites) that carry out these functions. Cell cycle regulation in yeast is an appropriate test case for this ambition, because the scientific community has amassed much information about the molecular components and functional properties of the control system. We propose a general mechanism for the regulation of cyclin-dependent kinases, the enzymes that control the major events of the cell cycle (DNA synthesis, mitosis and cell division). We translate the mechanism into differential-algebraic equations, and study solutions of these equations by numerical simulations and one-parameter bifurcation diagrams. We present results for wild type cells and a mutant that undergoes repeated rounds of DNA replication without intervening mitoses. We use bifurcation diagrams to reveal the general principles by which a cell controls its progression through the cell cycle.

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Author information

Authors and Affiliations

  1. Molecular Network Dynamics Research Group, Budapest University of Technology and Economics and Hungarian Academy of Sciences, 1111 Budapest, Gellért tér 4, Hungary

    Béla Novák

  2. Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, VA 24061, USA

    Katherine C. Chen & John J. Tyson

Authors
  1. Béla Novák
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  2. Katherine C. Chen
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  3. John J. Tyson
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Corresponding author

Correspondence to Béla Novák .

Editor information

Lila Alberghina H.V. Westerhoff

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Novák, B., Chen, K.C., Tyson, J.J. Systems biology of the yeast cell cycle engine. In: Alberghina, L., Westerhoff, H. (eds) Systems Biology. Topics in Current Genetics, vol 13. Springer, Berlin, Heidelberg. https://doi.org/10.1007/b137123

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