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Herpesvirus Genome Replication

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Viral Genome Replication

The Herpesviridae are a large family of enveloped, double-stranded DNA viruses that are responsible for many human and veterinary diseases. Herpesviruses can infect mammals, birds, and reptiles, and so far, eight distinct family members have been found which infect humans including herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2), Epstein–Barr virus (EBV), cytomegalovirus (HCMV), varicella-zoster virus (VZV), human herpesvirus 6 (HHV-6), human herpesvirus 7 (HHV-7), and Kaposi’s sarcoma herpesvirus (KSHV). All members of the family are capable of both lytic and latent infections although they differ greatly in tissue tropism and in many aspects of their interactions with their hosts. These viruses share many aspects of virion structure (they all are T = 16), genomic organization, mechanisms of DNA replication and life cycle. Herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) are the most extensively studied of all the herpesviruses, in part because they are most amenable to genetic and biochemical approaches. This chapter will focus primarily on herpes simplex virus type 1 (HSV-1); however, other human herpesviruses will be discussed when their replication strategy differs in significant detail from simplex viruses.

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  1. Department of Molecular, Microbial and Structural Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-3205, USA

    Sandra K. Weller

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    Weller, S.K. (2009). Herpesvirus Genome Replication. In: Raney, K., Gotte, M., Cameron, C. (eds) Viral Genome Replication. Springer, Boston, MA. https://doi.org/10.1007/b135974_13

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