Abstract
Organometallic transformations involving titanium are employed both catalytically and stoichiometrically in the pharmaceutical and fine chemical industry. The current review outlines a number of examples of the industrial applications of organotitanium reagents over the past decade. In addition, several reactions are briefly reviewed for which no industrial applications have been reported, but for which commercial utility may be envisaged. The review is organized by reaction type: carbon-carbon bond formation, carbon-heteroatom bond formation, oxidations, reductions, and hydrolysis/ester formation.
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Abbreviations
- BINOL:
-
1,1-Binaphth-2-ol
- Cp:
-
Cyclopentadienyl
- de:
-
Diasteromeric excess
- ee:
-
Enantiomeric excess
- TADDOL:
-
Tetraaryl-1,3-dioxolane-4,5-dimethanol
- TMEDA:
-
Tetramethylethylenediamine
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Hughes, D.L. Applications of Organotitanium Reagents. In: Organometallics in Process Chemistry. Topics in Organometallic Chemistry, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/b11770
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DOI: https://doi.org/10.1007/b11770
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-01603-8
Online ISBN: 978-3-540-36966-0
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