Learning Objectives
After reading this chapter and answering the discussion questions that follow, you should be able to
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Present a concise overview of the global burden of TB among women and children, highlighting differences in trends in developed and less-developed countries.
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Identify risk factors for childhood TB and discuss the challenges of diagnosing and tracking TB in children.
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Describe the pathogenesis of TB and discuss the relationship between TB and HIV/AIDS.
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Appraise the global challenges posed by multidrug-resistant TB.
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Critically assess options for treatment and prevention of TB among women and children, and discuss the associated challenges.
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References
Aronson NE, Santosham M, Comstock GW et al. (2004) Long-term efficacy of BCG vaccine in American Indians and Alaska Natives: A 60-year follow-up study. Journal of the American Medical Association, 291(17), 2086–2091
Bachou H, Tylleskar T, Downing R et al. (2006) Severe malnutrition with and without HIV-1 infection in hospitalized children in Kampala, Uganda: differences in clinical features, haematological findings and CD4+ cell counts. Nutrition Journal, 5, 27
Behr MA, Warren S, Salamon H et al. (1999) Transmission of Mycobacterium tuberculosis from patients smear-negative for acid-fast bacilli. Lancet, 353(9151), 444–449
Berman S, Kibel MA, Fourie PB et al. (1992) Childhood tuberculosis and tuberculous meningitis: high incidence rates in the Western Cape of South Africa. Tuberculosis and Lung Disease, 73(6), 349–355
Bierrenbach AL, Cunha S, Barreto M et al. (2003) Tuberculin reactivity in a population of schoolchildren with high BCG vaccination coverage. Revista Panama de Salud Publica, 13(5), 285–293
Bjerkedal T, Bahna SL, Lehmann EH (1975) Course and outcome of pregnancy in women with pulmonary tuberculosis. Scandinavian Journal of Respiratory Diseases, 56(5), 245–250
Black GF, Weir RE, Floyd S et al. (2002) BCG-induced increase in interferon-gamma response to mycobacterial antigens and efficacy of BCG vaccination in Malawi and the UK: two randomized controlled studies. Lancet, 359(9315), 1393–1401
Brost BC, Newman RB (1997) The maternal and fetal effects of tuberculosis therapy. Obstetrics and Gynecology Clinics of North America, 24(3), 659–673
Burk JR, Bahar D, Wolf FS et al. (1978) Nursery exposure of 528 newborns to a nurse with pulmonary tuberculosis. Southern Medical Journal, 71(1), 7–10
Cantwell MF, Binkin NJ (1997) Impact of HIV on tuberculosis in sub-Saharan Africa: a regional perspective. International Journal of Tuberculosis and Lung Disease, 1(3), 205–214
Cantwell MF, Shehab Z, Costello A et al. (1994) Brief report: congenital tuberculosis. New England Journal of Medicine, 330(15), 1051–1054
Carter EJ, Mates S (1994) Tuberculosis during pregnancy. The Rhode Island experience, 1987 to 1991. Chest, 106(5), 1466–1470
Cauthen GM, Pio A, ten Dam HG (2002) Annual risk of tuberculous infection. 1988. Bulletin of the World Health Organization, 80(6), 503–511; discussion 501–502
Chintu C, Mudenda V, Lucas S et al. (2002) Lung diseases at necropsy in African children dying from respiratory illnesses: a descriptive necropsy study. Lancet, 360(9338), 985–990
Chintu C, Mwaba P (2005) Tuberculosis in children with human immunodeficiency virus infection. International Journal of Tuberculosis and Lung Disease, 9(5), 477–484
Chow F, Espiritu N, Gilman RH et al. (2006) La cuerda dulce – a tolerability and acceptability study of a novel approach to specimen collection for diagnosis of pediatric pulmonary tuberculosis. BMC Infectious Diseases, 6, 67
Colditz GA, Brewer TF, Berkey CS et al. (1994) Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature. Journal of the American Medical Association, 271(9), 698–702
Comstock GW, Livesay VT, Woolpert SF (1974) The prognosis of a positive tuberculin reaction in childhood and adolescence. American Journal of Epidemiology, 99(2), 131–138
Daley CL, Small PM, Schecter GF et al. (1992) An outbreak of tuberculosis with accelerated progression among persons infected with the human immunodeficiency virus. An analysis using restriction-fragment-length polymorphisms. New England Journal of Medicine, 326(4), 231–235
Datta M, Vallishayee RS, Diwakara AM (1999) Fifteen year follow up of trial of BCG vaccines in south India for tuberculosis prevention. Tuberculosis Research Centre (ICMR), Chennai. Indian Journal of Medical Research, 110, 56–69
de March AP (1975) Tuberculosis and pregnancy. Five- to ten-year review of 215 patients in their fertile age. Chest, 68(6), 800–804
Doveren RF, Block R (1998) Tuberculosis and pregnancy–a provincial study (1990–1996). Netherlands Journal of Medicine, 52(3), 100–106
Eamranond P, Jaramillo E (2001) Tuberculosis in children: reassessing the need for improved diagnosis in global control strategies. International Journal of Tuberculosis and Lung Disease, 5(7), 594–603
Enarson PM, Enarson DA, Gie R (2005) Management of tuberculosis in children in low-income countries. International Journal of Tuberculosis and Lung Disease, 9(12), 1299–1304
Espinal MA, Reingold AL, Lavandera M (1996) Effect of pregnancy on the risk of developing active tuberculosis. Journal of Infectious Diseases, 173(2), 488–491
Figueroa-Damian R, Arredondo-Garcia JL (1998) Pregnancy and tuberculosis: influence of treatment on perinatal outcome. American Journal of Perinatology, 15(5), 303–306
Franchi LM, Cama RI, Gilman RH et al. (1998) Detection of Mycobacterium tuberculosis in nasopharyngeal aspirate samples in children. Lancet, 352(9141), 1681–1682
Getchell WS, Davis C, Gilman J et al. (1992) Basic epidemiology of tuberculosis in Peru: a prevalence study of tuberculin sensitivity in a Pueblo joven. American Journal of Tropical Medicine and Hygiene, 47(6), 721–729
Good JT Jr., Iseman MD, Davidson PT et al. (1981) Tuberculosis in association with pregnancy. American Journal of Obstetrics and Gynecology, 140(5), 492–498
Grisolle A (1850) De l'influence que la grossesse et laphthisie pulmonaire exercant reciproquement l’unesur l’autre. Archives of General Medicine, 22:41
Halsey NA, Chaisson RE, Matts JP et al. (1998) Randomized trial of isoniazid versus rifampicin and pyrazinamide for prevention of tuberculosis in HIV-1 infection. Lancet, 351(9105), 786–792
Hart PD, Sutherland I (1977) BCG and vole bacillus vaccines in the prevention of tuberculosis in adolescence and early adult life. British Medical Journal, 2(6082), 293–295
Hedvall E (1953) Pregnancy and tuberculosis. Acta Medica Scandinavica Supplement, 286, 1–101
Hershfield E (1991) Tuberculosis in children: guidelines for diagnosis, prevention and management (a statement of the scientific committees of the IUATLD). Bulletin of the International Union Against Tuberculosis and Lung Disease, 66, 61–67
Hesseling AC, Schaaf H, Gie R et al. (2002) A critical review of diagnostic approaches used in the diagnosis of childhood tuberculosis. International Journal of Tuberculosis and Lung Disease, 6(12), 1038–1045
Holmes CB, Hausler H, Nunn P (1998) A review of sex differences in the epidemiology of tuberculosis. International Journal of Tuberculosis and Lung Disease, 2(2), 96–104
Houwert KA, Borggreven P, Schaaf et al. (1998) Prospective evaluation of World Health Organization criteria to assist diagnosis of tuberculosis in children. European Respiratory Journal, 11(5), 1116–1120
Jackson TD, Murtha AP (2001) Anergy during pregnancy. American Journal of Obstetrics and Gynecology, 184(6), 1090–1092
Jana N, Vasishta K, Saha S et al. (1999) Obstetrical outcomes among women with extrapulmonary tuberculosis. New England Journal of Medicine, 341(9), 645–649
Jones CA (2001) Maternal transmission of infectious pathogens in breast milk. Journal of Pediatric Child Health, 37(6), 576–582
Kawai V, Soto G, Gilman R et al. (2006) Tuberculosis mortality, drug resistance, and infectiousness in patients with and without HIV infection in Peru. American Journal of Tropical Medicine and Hygiene, 75(6), 1027–1033
Kothari A, Mahadevan N, Girling J (2006) Tuberculosis and pregnancy – results of a study in a high prevalence area in London. European Journal of Obstetrics and Gynecologic Reproductive Biology, 126(1), 48–55
Kumar D, Watson JM, Charlette A et al. (1997) Tuberculosis in England and Wales in 1993: results of a national survey. Thorax, 52(12), 1060–1067
Llewelyn M, Cropley I, Wilkinson RJ et al. (2000) Tuberculosis diagnosed during pregnancy: a prospective study from London. Thorax, 55(2), 129–132
Lockman S, Tappero JW, Kenyon TA et al. (1999) Tuberculin reactivity in a pediatric population with high BCG vaccination coverage. International Journal of Tuberculosis and Lung Disease, 3(1), 23–30
Luo C, Chintu C, Bhat G et al. (1994) Human immunodeficiency virus type-1 infection in Zambian children with tuberculosis: changing seroprevalence and evaluation of a thioacetazone-free regimen. Tuberculosis and Lung Disease, 75(2), 110–115
Marais BJ, Gie RP, Schaaf HS et al. (2004) The natural history of childhood intra-thoracic tuberculosis: a critical review of literature from the pre-chemotherapy era. International Journal of Tuberculosis and Lung Disease, 8(4), 392–402
Marais BJ, Gie RP, Schaaf HS et al. (2006a) The spectrum of disease in children treated for tuberculosis in a highly endemic area. International Journal of Tuberculosis and Lung Disease, 10(7), 732–738
Marais BJ, Hesseling AC, Gie RP et al. (2006b) The bacteriologic yield in children with intrathoracic tuberculosis. Clinical Infectious Diseases, 42(8), e69–e71
Marais BJ, Hesseling AC, Gie RP et al. (2006c) The burden of childhood tuberculosis and the accuracy of community-based surveillance data. International Journal of Tuberculosis and Lung Disease, 10(3), 259–263
Marais BJ, Obihara C, Warren RM et al. (2005) The burden of childhood tuberculosis: a public health perspective. International Journal of Tuberculosis and Lung Disease, 9(12), 1305–1313
Margono F, Mroueh J, Garely A et al. (1994) Resurgence of active tuberculosis among pregnant women. Obstetrics and Gynecology, 83(6), 911–914
Moore DA, Mendoza D, Gilman R et al. (2004) Microscopic observation drug susceptibility assay, a rapid, reliable diagnostic test for multidrug-resistant tuberculosis suitable for use in resource-poor settings. Journal of Clinical Microbiology, 42(10), 4432–4437
Moore DA, Evans CA, Gilman RH et al. (2006) Microscopic-observation drug-susceptibility assay for the diagnosis of TB. New England Journal of Medicine, 355(15), 1539–1550
Moulding T (1999) Pathogenesis, pathophysiology, and immunology: clinical orientations. In: D Schlossberg (ed.), Tuberculosis and Non-Tuberculous Mycobacterial Infections. Philadelphia: W.B. Saunders, pp. 48–56
Mukadi YD, Wiktor S, Coulibaly I et al. (1997) Impact of HIV infection on the development, clinical presentation, and outcome of tuberculosis among children in Abidjan, Cote d'Ivoire. Aids, 11(9), 1151–1158
Mwaba P, Maboshe M, Chintu C et al. (2003) The relentless spread of tuberculosis in Zambia – trends over the past 37 years (1964–2000). South African Medical Journal, 93(2), 149–152
Mwinga A (2005) Challenges and hope for the diagnosis of tuberculosis in infants and young children. Lancet, 365(9454), 97–98
Nelson LJ, Wells CD (2004) Global epidemiology of childhood tuberculosis. International Journal of Tuberculosis and Lung Disease, 8(5), 636–647
Nemir RL, O'Hare D (1985) Congenital tuberculosis. Review and diagnostic guidelines. American Journal of the Disabled Child, 139(3), 284–287
Nolan CM, Goldberg SV, Buskin SE (1999) Hepatotoxicity associated with isoniazid preventive therapy: a 7-year survey from a public health tuberculosis clinic. Journal of the American Medical Association, 281(11), 1014–1018
Oberhelman RA, Soto-Castellares G, Caviedes L et al. (2006). Improved recovery of Mycobacterium tuberculosis from children using the microscopic observation drug susceptibility method. Pediatrics, 118(1), e100–e106
O'Brien KL, Ruff AJ, Louis MA et al. (1995) Bacillus Calmette–Guérin complications in children born to HIV-1-infected women with a review of the literature. Pediatrics, 95(3), 414–418
Ormerod P (2001) Tuberculosis in pregnancy and the puerperium. Thorax, 56(6), 494–499
Palme IB, Gudetta B, Degefu H et al. (2001) Risk factors for human immunodeficiency virus infection in Ethiopian children with tuberculosis. Pediatric Infectious Disease Journal, 20(11), 1066–1072
Park MM, Davis AL, Schluger NW et al. (1996) Outcome of MDR-TB patients, 1983–1993. Prolonged survival with appropriate therapy. American Journal of Respiratory and Critical Care Medicine, 153(1), 317–324
Pelly TF, Santillan CF, Gilman RH et al. (2005) Tuberculosis skin testing, anergy and protein malnutrition in Peru. International Journal of Tuberculosis and Lung Disease, 9(9), 977–984
Ponnighaus JM, Fine PE, Sterne JA et al. (1992) Efficacy of BCG vaccine against leprosy and tuberculosis in northern Malawi. Lancet, 339(8794), 636–639
Ramirez-Cardich ME, Kawai V, Oberhelman RA et al. (2006) Clinical correlates of tuberculosis co-infection in HIV-infected children hospitalized in Peru. International Journal of Infectious Disease, 10(4), 278–281
Rodriguez L, Gonzales C, Flores L et al. (2005) Assessment by flow cytometry of cytokine production in malnourished children. Clinical and Diagnostic Laboratory Immunology, 12(4), 502–507
Saito M, Bautista CT, Gilman RH et al. (2004) The value of counting BCG scars for interpretation of tuberculin skin tests in a tuberculosis hyperendemic shantytown, Peru. International Journal of Tuberculosis and Lung Disease, 8(7), 842–847
Salazar GE, Schmitz T, Cama R et al. (2001) Pulmonary tuberculosis in children in a developing country. Pediatrics, 108(2), 448–453
Santiago EM, Lawson E, Gillenwater K et al. (2003) A prospective study of bacillus Calmette–Guérin scar formation and tuberculin skin test reactivity in infants in Lima, Peru. Pediatrics, 112(4), e298
Schaaf HS, Gie RP, Beyers N et al. (2000) Primary drug-resistant tuberculosis in children. International Journal of Tuberculosis and Lung Disease, 4(12), 1149–1155
Schaefer G, Zervoudakis IA, Fuchs FF et al. (1975) Pregnancy and pulmonary tuberculosis. Obstetrics and Gynecology, 46(6), 706–715
Shafer RW, Small PM, Larkin C et al. (1995) Temporal trends and transmission patterns during the emergence of multidrug-resistant tuberculosis in New York City: a molecular epidemiologic assessment. Journal of Infectious Diseases, 171(1), 170–176
Shingadia D, Novelli V (2003) Diagnosis and treatment of tuberculosis in children. Lancet Infectious Diseases, 3(10), 624–632
Starke JR (1999) Tuberculosis in infants and children. In: D Schlossberg (ed.), Tuberculosis and Nontuberculous Mycobacterial Infections (Fourth Edition). Philadelphia: W.B. Saunders, pp. 303–324
Sterne JA, Rodrigues LC, Guedes IN (1998) Does the efficacy of BCG decline with time since vaccination? International Journal of Tuberculosis and Lung Disease, 2(3), 200–207
Toledo A, Stegen G (1979) Criterios de diagnóstico en tuberculosis infantil (Diagnostic criteria for pediatric tuberculosis). Revista Mexicana de PediatrÃa, 46, 239–243
Tripathy SN, Tripathy SN (2003) Tuberculosis and pregnancy. International Journal of Gynaecology and Obstetrics, 80(3), 247–253
U.S. Department of Health and Human Services (2007) Glossary of Terms Related to TB. Atlanta, Georgia: Centers for Disease Control and Prevention. http://www.cdc.gov/tb/faqs/qa_glossary.htm Cited August 9, 2009
Ussery XT, Valway SE, McKenna M et al. (1996) Epidemiology of tuberculosis among children in the United States: 1985 to 1994. Pediatric Infectious Disease Journal, 15(8), 697–704
Vallejo JG, Ong LT, Starke JR (1994) Clinical features, diagnosis, and treatment of tuberculosis in infants. Pediatrics, 94(1), 1–7
Vargas D, Garcia L, Gilman RH et al. (2005) Diagnosis of sputum-scarce HIV-associated pulmonary tuberculosis in Lima, Peru. Lancet, 365(9454), 150–152
Walls T, Shingadia D (2004) Global epidemiology of pediatric tuberculosis. Journal of Infection, 48(1), 13–22
Whalen C, Horsburgh CR, Hom D et al. (1995) Accelerated course of human immunodeficiency virus infection after tuberculosis. American Journal of Respiratory Critical Care Medicine, 151(1), 129–135
Wilson ME, Fineberg HV, Colditz GA (1995) Geographic latitude and the efficacy of bacillus Calmette–Guérin vaccine. Clinical Infectious Diseases, 20(4), 982–991
Zar HJ, Hanslo D, Apolles P et al. (2005) Induced sputum versus gastric lavage for microbiological confirmation of pulmonary tuberculosis in infants and young children: a prospective study. Lancet, 365(9454), 130–134
Zwarenstein M, Schoeman JH, Vundule C (1998) Randomized controlled trial of self-supervised and directly observed treatment of tuberculosis. Lancet, 352(9137), 1340–1343
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Reddy, K., Moore, D., Gilman, R. (2009). Tuberculosis in Childhood and Pregnancy. In: Ehiri, J. (eds) Maternal and Child Health. Springer, Boston, MA. https://doi.org/10.1007/b106524_14
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