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Shiga toxins and their mechanisms of cell entry

  • Chapter
  • First Online:
Microbial Protein Toxins

Part of the book series: Topics in Current Genetics ((TCG,volume 11))

Abstract

The Shiga toxins (Stxs) are related toxins secreted by Shigella dysenteriae, Escherichia coli in addition to other bacteria. They all act by entering cells and inhibiting protein synthesis enzymatically, thereby, killing the cells. Toxicity can also be mediated by induction of apoptosis. Furthermore, the Shiga toxins can in some cells induce secretion of a number of cytokines, some of which may induce synthesis of the toxin receptor Gb3 in other cell types. The toxins are important tools in studies of intracellular pathways, and knowledge about interactions of the toxins with cells are important to prevent and cure diseases caused by these highly potent agents. Knowledge about the toxins and their entry process can be exploited in attempts to use Stxs or their subunits also for therapeutic purposes. This article will focus on the entry process of Stxs.

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  1. Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway

    Kirsten Sandvig, Sébastien Wälchli & Silje U. Lauvrak

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  1. Kirsten Sandvig
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  2. Sébastien Wälchli
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Correspondence to Kirsten Sandvig .

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Manfred J. Schmitt Raffael Schaffrath

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Sandvig, K., Wälchli, S., Lauvrak, S.U. Shiga toxins and their mechanisms of cell entry. In: Schmitt, M.J., Schaffrath, R. (eds) Microbial Protein Toxins. Topics in Current Genetics, vol 11. Springer, Berlin, Heidelberg. https://doi.org/10.1007/b100512

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