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Structure and assembly of the sarcomeric M Band

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Book cover Reviews of Physiology, Biochemistry and Pharmacology

Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology ((REVIEWS,volume 138))

Abstract

M bands and Z discs seem to be crucially involved in establishing the strikingly ordered array of thick and thin filaments, respectively. This requires control mechanisms that allow for the sequential assembly of contractile and structural proteins into the sarcomere. In addition, tightly controlled local disassembly processes have to provide a basis for the turnover and remodelling that has been observed (like, for instance, the exchange of developmental stage-specific sarcomere protein isoforms in a working muscle). Previous work has focussed on the characterization of a plethora of contractile and cytoskeletal proteins. More recent results give good reasons to hope that it may be possible to explain the various ultrastructural findings at a molecular level in the future. Likewise, they give a first hint at which signal transduction mechanisms could be involved in the control of the assembly of the supramolecular structure that makes us move.

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Authors and Affiliations

  1. Department of Cell Biology, University of Potsdam, Germany

    D. O. Fürst & P. F. M. van der Ven

  2. Department of Cellular Biochemistry, Max-Planck-Institute for Biochemistry, Martinsried, Germany

    W. M. J. Obermann

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  1. D. O. Fürst
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  2. W. M. J. Obermann
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  3. P. F. M. van der Ven
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Fürst, D.O., Obermann, W.M.J., van der Ven, P.F.M. (1999). Structure and assembly of the sarcomeric M Band. In: Reviews of Physiology, Biochemistry and Pharmacology. Reviews of Physiology, Biochemistry and Pharmacology, vol 138. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0119627

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  • DOI: https://doi.org/10.1007/BFb0119627

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