Comparative aspects of muscle elastic proteins

  • K. Maruyama
Part of the Reviews of Physiology, Biochemistry and Pharmacology book series (REVIEWS, volume 138)


Sarcomere Length Flight Muscle Myosin Filament Horse Mackerel Comparative Aspect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Auber J, Couteaux R (1963) Ultrastructure de la strie dans des muscle de Dipteres. J Microsc Paris 2:309–324Google Scholar
  2. Ayme-Southgate A, Vigoreaux J, Benian G M, Pardue M L (1991) Drosophila has a twitchin/titin-related gene that appears to encode projectin. Proc Natl Acad Sci USA 88:7973–7977PubMedCrossRefGoogle Scholar
  3. Ayme-Southgate A, Southgate R, Saide J D, Benian G M, Pardue M L (1995) Both synchronous and asynchronous muscle isoforms of projectin (the Drosophila bent locus product) contain functional kinase domains. J Cell Biol 128:393–403PubMedCrossRefGoogle Scholar
  4. Benian G M, Kiff J E, Neckelmann N, Moerman D G, Waterston R H (1989) Sequence of an unusually large protein implicated in regulation of myosin activity in C. elegans. Nature 342:45–50PubMedCrossRefGoogle Scholar
  5. Benian G M, L’Hernault S W, Morris M E (1993) Additional sequence complexity in the muscle gene, unc-22, and its encoded protein, twitchin, of C. elegans. Genetics 134:1097–1104PubMedGoogle Scholar
  6. Benian G M, Tang X, Tinly T L (1996a) Twitchin and related giant Ig super family members of C. elegtans and other invertebrates. Adv Biophys 33:175–198CrossRefGoogle Scholar
  7. Benian G M, Tinley T L, Tang X, Borodovsky M (1996b) The Caenorhabditis elegans gene unc-89, required for muscle M-line assembly, encodes a giant modular protein composed of Ig and signal transduction domains. J Cell Biol 132:835–848PubMedCrossRefGoogle Scholar
  8. Bullard B, Leonard K (1996) Modular proteins of insect muscle. Adv Biophys 33:211–222PubMedCrossRefGoogle Scholar
  9. Eilertsen K J, Keller T C S (1992) Identification and characterization of two huge protein components of the brush border cytoskeleton: Evidence for a cellular isoform of titin. J Cell Biol 119:549–557PubMedCrossRefGoogle Scholar
  10. Eilertsen K J, Kazmierski S T, Keller T C S (1994) Cellular titin localization in stress fibers and interaction with myosin II filaments in vitro. J Cell Biol 126:1201–1210PubMedCrossRefGoogle Scholar
  11. Fukuzawa A, Kohei S, Yajima H, Kimura S, Maruyama K (1997) Partial sequence of crayfish claw muscle connectin and its localization. Zool Sci 14:54Google Scholar
  12. Fürst D O, Osborn M, Nave R, Weber K (1988) The organization of titin filaments in the half-sarcomere revealed by monoclonal antibodies in immunoelectron microscopy: A map of ten nonrepetitive epitopes starting at the Z line extends close to the M line. J Cell Biol 106:1563–1572PubMedCrossRefGoogle Scholar
  13. Fyrberg C C, Labeit S, Bullard B, Leonard K, Fyrberg E (1992) Drosophila projectin: relatedness to titin and twitchin and correlation with lethal (4) 102 CDa and bent-dominant mutants. Proc Roy Soc Lond B 249:33–40CrossRefGoogle Scholar
  14. Guba F, Harsasnyi V, Vajda E (1968) Ultrastructure of myofibrils after selective protein extraction. Acta Biochim Biophys Acad Sci Hung 3:435–442Google Scholar
  15. Hattori A, Ishii T, Tatsumi R, Takahashi K (1995) Changes in the molecular types of connectin and nebulin during development of chicken skeletal muscle. Biochim Biophys Acta 1244:179–184PubMedGoogle Scholar
  16. Heierhorst J, Probst W C, Vilim F S, Buku A, Weiss K R (1994) Autophosphorylation of molluscan twitchin and interaction of its kinase domain with calcium/calmodulin. J Biol Chem 269:21086–21093PubMedGoogle Scholar
  17. Heierhorst J, Probst W C, Kohanski R A, Buku A, Weiss K R (1995) Phosphorylation of myosin regulatory light chains by the molluscan twitchin kinase. Eur J Biochem 233:426–431PubMedCrossRefGoogle Scholar
  18. Heierhorst J, Kobe B, Feil S C, Parker M W, Benian G M, Weiss K R, Kemp B E (1996) Ca2+/S100 regulation of giant protein kinases. Nature 380:636–639PubMedCrossRefGoogle Scholar
  19. Hoyle G (1983) Muscle and their neural control. John Wiley and Sons, New York, pp 90–100Google Scholar
  20. Horowits R, Kempner E S, Bisher M E, Podolsky R J (1986) A physiological role for titin and nebulin in skeletal muscle. Nature 323:160–164PubMedCrossRefGoogle Scholar
  21. Hu D H, Kimura S, Maruyama K (1986) Sodium dodecyl sulfate gel electrophoresis studies of connectin-like high molecular weight proteins of various types of vertebrate and invertebrate muscles. J Biochem 99:1485–1492PubMedGoogle Scholar
  22. Hu D H, Kimura S, Kawashima S, Maruyama K (1989) Calcium-activated neutral protease quickly converts α-connectin to β-connectin in chicken breast muscle myofibrils. Zool Sci 6:797–800Google Scholar
  23. Hu D H, Matsuno A, Terakado K, Matsuura T, Kimura S, Maruyama K (1990) Projectin is an invertebrate connectin (titin): Isolation from crayfish claw muscle and localization in crayfish claw muscle and insect flight muscle. J Muscle Res Cell Motil 11:497–511PubMedCrossRefGoogle Scholar
  24. Huxley H E, Hanson J (1954) Changes in the cross striations of muscle during contraction and stretch and their structural interpretations. Nature 173:973–976PubMedCrossRefGoogle Scholar
  25. Itoh Y, Hu D H, Ohashi K, Kimura S, Maruyama K (1987) Lamprey connectin. Zool Sci 4:379–380Google Scholar
  26. Kawamura Y, Ohtani Y, Maruyama K (1994a) Biodiversity of the localization of the epitopes to connectin antibodies in the sarcomeres of lamprey, electric ray, and horse mackerel skeletal muscles. Tissue & Cell 26:677–685CrossRefGoogle Scholar
  27. Kawamura Y, Suzuki J, Kimura S, Maruyama K (1994b) Characterization of connectin-like proteins of obliquely striated muscle of a polychaete (Annelida). J Muscle Res Cell Motil 15:623–632PubMedCrossRefGoogle Scholar
  28. Kawamura Y, Ohtsuka H, Murata H, Maki S, Ohtani Y, Manabe T, Kimura S, Maruyama K (1996) Comparative aspects of muscle elastic protein. Adv Biophys 33:175–181PubMedCrossRefGoogle Scholar
  29. Kellermayer M S, Smith S B, Granzier H L, Bustamante C (1997) Folding-unfolding transtitions in single titin molecules characterized with laser tweezers. Science 276:1112–1116PubMedCrossRefGoogle Scholar
  30. Kimura S, Maruyama K (1983) Preparation of native connectin from chicken breast muscle. J Biochem 94:2083–2085PubMedGoogle Scholar
  31. Kimura S, Maruyama K (1989) Isolation of α-connectin, an elastic protein, from rabbit skeletal muscle. J Biochem 106:952–954PubMedGoogle Scholar
  32. Kimura S, Maki S, Maruyama K (1993) The role of a thiol protease in the proteolysis of connectin in rabbit skeletal muscle myofibrils. Biomed Res 14 Suppl 2:89–92Google Scholar
  33. Kimura S, Kawamura Y, Kubokawa K, Watanabe A, Maruyama K (1997) Connectinlike protein in Amphioxus striated muscle. Zool Sci 14:78Google Scholar
  34. Labeit S, Kolmerer B (1995) Titins: Giant proteins in charge of muscle ultrastructure and elasticity. Science 270:293–296PubMedCrossRefGoogle Scholar
  35. Lakey A, Ferguson C, Labeit S, Reedy M, Larkins A, Butcher G, Leonard K, Bullard B (1990) Identification and localization of high molecular weight proteins in insect flight and leg muscle. EMBO J 9:3459–3467PubMedGoogle Scholar
  36. Lakey A, Labeit S, Gautel M, Ferguson C, Barlow D P, Leonard K, Bullard B (1993) Kettin, a large modular protein in the Z-disc of insect muscles. EMBO J 12:2863–2871PubMedGoogle Scholar
  37. Locker R H, Wild D J C (1986) A comparative study of high molecular weight proteins in various types of muscle across the animal kingdom. J Biochem 99:1473–1484PubMedGoogle Scholar
  38. Maki S, Kimura S, Maruyama K (1994) Localization of connectin-like proteins in the giant sarcomeres of barnacle muscle. Zool Sci 11:821–824Google Scholar
  39. Maki S, Ohtani Y, Kimura S, Maruyama K (1995) Isolation and characterization of a kettin-like protein from crayfish claw muscle. J Muscle Res Cell Motil 16:579–585PubMedCrossRefGoogle Scholar
  40. Manabe T, Kawamura Y, Higuchi H, Kimura S, Maruyama K (1993) Connectin, giant elastic protein, in giant sarcomeres of crayfish claw muscle. J Muscle Res Cell Motil 14:654–665PubMedCrossRefGoogle Scholar
  41. Maruyama K, Matsubara S, Natori Y, Nonomura Y, Kimura S, Ohashi K, Murakami F, Handa S, Eguchi G (1977) Connectin, an elastic protein of muscle: characterization and function. J Biochem 82:317–337PubMedGoogle Scholar
  42. Maruyama K, Kimura S, Yoshidomi H, Sawada H, Kikuchi M (1984) Molecular size and shape of β-connectin, an elastic protein of striated muscle. J Biochem 95:1423–1433PubMedGoogle Scholar
  43. Maruyama K (1986) Connectin, an elastic filamentous protein of striated muscle. Int Rev Cytol 104:81–114PubMedCrossRefGoogle Scholar
  44. Maruyama K (1994) Connectin, an elastic protein of striated muscle. Biophys Chem 50:73–85PubMedCrossRefGoogle Scholar
  45. Maruyama K, Ohtani Y, Maki S, Kawamura Y, Benian G M, Kagawa H, Kimura S (1995) Connectin-related phenomena and biodiversity of the connectin family. In: Maruyama K, Nonomura Y, Kohama K (eds) Calcium as cell signal. Igakushoin, Tokyo, pp 73–79Google Scholar
  46. Maruyama K, Kimura S (eds) (1996) Muscle elastic proteins. Adv Biophys 33:1–241Google Scholar
  47. Maruyama K (1997) Connectin/Titin, giant elastic protein of muscle. FASEB J 11:341–345PubMedGoogle Scholar
  48. Matsuno A, Takano-Ohmuro H, Itoh Y, Matsuura T, Shibata M, Nakae H, Kaminuma T, Maruyama K (1989) Anti-connectin monoclonal antibodies that react with the unc-22 gene product bind dense bodies of Caenorhabditis (nematode) bodywall muscle cells. Tissue & Cell 21:495–505CrossRefGoogle Scholar
  49. McNail P A, Hoyle G (1967) Evidence for superthin filaments. Am Zoologist 7:483–498Google Scholar
  50. Nakauchi Y, Maruyama K (1992) Immunoblot detection of vertebrate-type of connectin (titin) in ascidian bodywall muscle and tadpole. Zool Sci 9:219–221Google Scholar
  51. Natori R (1954) The property and contraction process of isolated myofibrils. Jikeikai Med J 1:18–23Google Scholar
  52. Nave R, Weber K (1990) A myofibrillar protein of insect muscle related to vertebrate titin connects Z-band and A-band:purification and molecular characterization of invertebrate mini-titin. J Cell Sci 95:535–544PubMedGoogle Scholar
  53. Nave R, Fürst D O, Vinkemeier U, Weber K (1991) Purification and physical properties of nematode mini-titins and their relation to twitchin. J Cell Sci 98:491–496PubMedGoogle Scholar
  54. Obinata T (1993) Contractile proteins and myofibrillogenesis. Int Rev Cytol 143:153–189PubMedCrossRefGoogle Scholar
  55. Ohtani Y, Maki S, Kimura S, Maruyama K (1996) Localization of connectin-like proteins in leg and flight muscles of insects. Tissue & Cell 28:1–8CrossRefGoogle Scholar
  56. Pringle J W S (1977) The mechanical characterization of insect fibrillar muscle. In: Tregear R T (eds) The mechanical characterization of insect fibrillar muscle. Elsevier, Amsterdam, pp 177–196 Probst W C, Cropper E C, Heierhorst J, Hooper S L, Jaffe H, Vilim F, Beushausen S.Google Scholar
  57. Kupfermann I, Weiss K R (1994) cAMP-dependent phosphorylation of Aplysia twitchin may mediate modulation of muscle contractions by neuropeptide cotransmitters. Proc Natl Acad Sci USA 91:8487–8491PubMedCrossRefGoogle Scholar
  58. Pudles J, Moudjou M, Hisanaga S, Maruyama K, Sakai H (1990) Isolation of a giant protein from sea-urchin egg cytomatrix. Exp Cell Res 189:253–256PubMedCrossRefGoogle Scholar
  59. Rief M, Gautel M, Oesterhelt F, Fernandez J M, Gaul H E (1997) Reversible unfolding of individual titin immunoglobulin domains by AFM. Science 276:1109–1112PubMedCrossRefGoogle Scholar
  60. Saide J D (1981) Identification of a connecting filament protein in insect fibrillar flight muscle. J Mol Biol 153:661–679PubMedCrossRefGoogle Scholar
  61. Saide J D, Chin-Bow S, Hogan-Sheldon J, Busquets-Turner L (1990) Z-band proteins in the flight muscle and leg muscle of the honeybee. J Muscle Res Cell Motil 11:125–136PubMedCrossRefGoogle Scholar
  62. Sjöstrand F S (1962) The connections between A-and I-band filaments in striated frog muscle. J Ultrastruct Res 7:225–246PubMedCrossRefGoogle Scholar
  63. Soeno Y, Yajima H, Kawamura Y, Kimura S, Maruyama K (1998) Organization of connectin/titin filaments in sarcomeres of differentiating chicken skeletal muscle cells. Mol Cell Biol in pressGoogle Scholar
  64. Sorimachi H, Kinbara K, Kimura S, Takahashi M, Ishiura S, Sasagawa N, Sorimachi N, Shimada H, Tagawa K, Maruyama K, Suzuki K (1995) Muscle-specific calpain, p94, responsible for limb girdle muscular dystrophy type 2A, associates with connectin through IS2, a p94-specific sequence. J Biol Chem 270:31158–31162PubMedCrossRefGoogle Scholar
  65. Tskhovrebova L, Trinick J, Sleep J A, Simmons R M (1997) Elasticity and unfolding of single molecules of the giant protein titin. Nature 387:308–312PubMedCrossRefGoogle Scholar
  66. Vibert P, Edelstein S M, Castellani L, Elliott B W (1993) Mini-titins in striated and smooth molluscan muscles — structure, location and immunological crossreactivity. J Muscle Res Cell Motil 14:598–607PubMedCrossRefGoogle Scholar
  67. Vibert P, York M L, Castellani L, Edelstein S M, Elliot B, Nyitray L. (1996) Structure and distribution of minititins. Adv Biophys 33:199–210PubMedCrossRefGoogle Scholar
  68. Wang K, McClure J, Tu A (1979) Titin: Major myofibrillar components of striated muscle. Proc Natl Acad Sci USA 76:3698–3702PubMedCrossRefGoogle Scholar
  69. Yajima H, Ohtsuka H, Kawamura Y, Kume H, Murayama T, Abe H, Kimura S, Maruyama K (1996) A 11.5-kb 5′-terminal cDNA sequence of chicken breast muscle connectin/titin reveals its Z line binding region. Biochem Biophys Res Comm 223:160–164PubMedCrossRefGoogle Scholar
  70. Yoshidomi H, Ohashi K, Maruyama K (1985) Changes in the molecular size ofconnectin, an elastic protein, in chicken skeletal muscle during embryonic and neonatal development. Biomed Res 6:207–212Google Scholar
  71. Ziegler, C (1994) Titin-related proteins in invertebrate muscles. Comp Biochem Physiol 109A:823–833CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1999

Authors and Affiliations

  • K. Maruyama
    • 1
  1. 1.Office of PresidentChiba UniversityChibaJapan

Personalised recommendations