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Molecular water pumps

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Reviews of Physiology Biochemistry and Pharmacology

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References

  • Agre P, Bonhivers M, Borgnia MJ (1998) The aquaporins, blueprints for cellular plumbing systems. J Biol Chem 273:14659–14662

    PubMed  CAS  Google Scholar 

  • Appelboom JWTh, Brodsky WA, Tuttle WS, Diamond I (1958) The freezing point depression of mammalian tissues after sudden heating in boiling distilled water. J Gen Physiol 41:1153–1169

    PubMed  CAS  Google Scholar 

  • Aull F (1981) Potassium chloride cotransport in steady-state ascites tumor cells. Biochim Biophys Acta 643:339–345

    PubMed  CAS  Google Scholar 

  • Barry PH, Diamond JM (1984) Effects of unstirred layers on membrane phenomena. Physiol Rev 64:763–872

    PubMed  CAS  Google Scholar 

  • Baslow MH (1998) Function of the N-acetyl-L-histidine system in the vertebrate eye: Evidence in support of a role as a molecular water pump. J Mol Neurosci 10(3) 193–208

    PubMed  CAS  Google Scholar 

  • Baslow MH (1999) The existence of molecular water pumps in the nervous system: a review of the evidence. Neurochem Int 34:77–90

    PubMed  CAS  Google Scholar 

  • Baum M, Berry CA (1984) Evidence for neutral transcellular NaCl transport and neutral basolateral chloride exit in the rabbit proximal convoluted tubule. J Clin Invest 74:205–211

    PubMed  CAS  Google Scholar 

  • Bianchini L, Fossat B, Porthe-Nibelle J, Ellory JC, Lahlou B (1988) Effects of hypoosmotic shock on ion fluxes in isolated trout hepatocytes. J Exp Biol 137:303–318

    PubMed  CAS  Google Scholar 

  • Boulpaep EL, Maunsbach AB, Tripathi S, et al (1993) Mechanisms of isosmotic water transport in leaky epithelia: Consensus and inconsistencies. In: Ussing HH, Fischbarg J, Sten-Knudsen O, et al (eds) Isotonic Transport in Leaky Epithelia. Munksgaard, Copenhagen, pp 53–67

    Google Scholar 

  • Bulone D, Donato ID, Palma-Vittorelli MB, Palma MU (1991) Density, structural lifetime, and entropy of H-bond cages promoted by monohydric alcohols in normal and supercooled water. J Chem Phys 94:6816–6826

    CAS  Google Scholar 

  • Bundgaard M, Zeuthen T (1982) Structure of Necturus gallbladder epithelium during transport at low external osmolarities. J Chem Biol 68:97–105

    CAS  Google Scholar 

  • Chen X-Z, Coady MJ, Jackson F, Berteloot A, Lapointe J-Y (1995) Thermodynamic determination of the Na+: glucose coupling ratio for the human SGLT1 cotransporter. Biophys J 69:2405–2414

    PubMed  CAS  Google Scholar 

  • Cherksey BD, Zeuthen T (1987) A membrane protein with a K+ and a Cl− channel. Journal of Physiology 387:33P

    Google Scholar 

  • Chrispeels MJ, Maurel C (1994) Aquaporins: The molecular basis of facilitated water movement through living plant cells? Plant Physiol 105:9–13

    PubMed  CAS  Google Scholar 

  • Colombo MF, Rau DC, Parsegian VA (1992) Protein Solvation in Allosteric Regulation: A Water Effect on Hemoglobin. Science 256:655–659

    PubMed  CAS  Google Scholar 

  • Conway EJ, Geoghegan H (1955) Molecular concentration of kidney cortex slices. J Physiol 130:438–445

    PubMed  CAS  Google Scholar 

  • Conway EJ, Geoghegan H, McCormack JI (1955) Autolytic changes at zero centigrade in ground mammalian tissues. J Physiol 130:427–437

    PubMed  CAS  Google Scholar 

  • Cotton CU, Reuss L (1989) Measurement of the effective thickness of the mucosal unstirred layer in Necturus gallbladder epithelium. J Gen Physiol. 93:631–647

    PubMed  CAS  Google Scholar 

  • Cotton CU, Reuss L (1991) Effects of changes in mucosal solution Cl− or K+ concentration on cell water volume of Necturus gallbladder epithelium. J Gen Physiol. 97:667–686

    PubMed  CAS  Google Scholar 

  • Cotton CU, Weinstein AM, Reuss L (1989) Osmotic water permeability of necturus gallbladder epithelium. J Gen Physiol 93:649–679

    PubMed  CAS  Google Scholar 

  • Curran PF, Macintosh JR (1962) A model system for biological water transport. Nature 193:347–348

    PubMed  CAS  Google Scholar 

  • Dainty J, House CR (1966) Unstirred layers in frog skin. J Physiol 182:66–78

    PubMed  CAS  Google Scholar 

  • Diamond JM (1979) Osmotic water flow in leaky epithelia. J Membr Biol 51:195–216

    PubMed  CAS  Google Scholar 

  • Doyle DA, Cabral JM, Pfuetzner RA, Kou A, Gulbis JM, Cohen SL, Chait BT, MacKinnon R (1998) The structure of the potassium channel: Molecular basis of K+ conduction and selectivity. Science 280:69–77

    PubMed  CAS  Google Scholar 

  • Eskandari S, Wright EM, Kreman M, Starace DM, Zampighi GA (1998) Structural analysis of cloned plasma membrane proteins by freeze-fracture electron microscopy. Proc Natl Acad Sci USA 95:11235–11240

    PubMed  CAS  Google Scholar 

  • Eveloff J, Warnock DG (1987) K−Cl transport systems in rabbit renal basolateral membrane vesicles. Am J Physiol 252:F883–F889

    PubMed  CAS  Google Scholar 

  • Fischbarg J, Kuang K, Vera JC, Arant S, Silverstein SC, Loike J, Rosen OM (1990) Glucose Transporters Serve as Water Channels. Proc Natl Acad Sci USA 87:3244–3247

    PubMed  CAS  Google Scholar 

  • Frambach DA, Weiter JJ, Adler AJ (1985) A photogrammetric method to measure fluid movement across isolated frog retinal pigment epithelium. Biophys J 47:547–552

    PubMed  CAS  Google Scholar 

  • Glasstone S, Laidler KJ, Eyring H (1941) The Theory of Rate Processes. McGraw-Hill Book Company, Inc, New York and London

    Google Scholar 

  • Green R, Giebisch G, Unwin R, Weinstein AM, (1991) Coupled water transport by rat proximal tubule. Am J Physiol 261:F1046–F1054

    PubMed  CAS  Google Scholar 

  • Greger R, Schlatter E (1983) Properties of the basolateral membrane of the cortical thick ascending limb of Henle’s loop of rabbit kidney. Pflüg Arch 396:325–334

    CAS  Google Scholar 

  • Guggino WB (1986) Functional heterogeneity in the early distal tubule of the Amphiuma kidney: evidence for two modes of Cl− and K+ transport across the basolateral cell membrane. Am J Physiol 250:F430–F440

    PubMed  CAS  Google Scholar 

  • Halm DR, Krasny EJ, Frizzell RA (1985) Electrophysiology of flounder intestinal mucosa. I. Conductance properties of the cellular and paracellular pathways. J Gen Physiol 85:843–864

    PubMed  CAS  Google Scholar 

  • Hamann S, La Cour M, Lui GM, Zeuthen T (1996) Transport of protons lactate and water in cultured fetal human RPE. Invest Ophthalmol Vis Sci 37:1109

    Google Scholar 

  • Hamann S, Zeuthen T, La Cour M, Nagelhus EA, Ottersen OP, Agre P, Nielsen S (1998) Aquaporins in complex tissues: distribution of aquaporins 1–5 in human and rat eye. Am J Physiol 274:C1332–C1345

    PubMed  CAS  Google Scholar 

  • Hasegawa H, Skack W, Baker O, Calayag MC, Lingappa V, Verkman AS (1992) A multifunctional aqueous channel formed by CFTR. Science 258:1477–1479

    PubMed  CAS  Google Scholar 

  • Heath H, Kang SS, Philoppou D (1975) Glucose, glucose-6-phosphate, lactate and pyruvate content of the retina, blood and liver of streptozotocin-diabetic rats fed sucrose-or starch-rich diets. Diabetologica 11:57–62

    CAS  Google Scholar 

  • Hediger MA, Coady MJ, Ikeda TS, Wright EM (1987) Expression cloning and cDNA sequencing of the Na+/glucose co-transporter. Nature 330:379–381

    PubMed  CAS  Google Scholar 

  • Heisey SR, Held D, Pappenheimer JR (1962) Bulk flow and diffusion in the cerebrospinal fluid system of the goat. Am J Physiol 203:775–781

    PubMed  CAS  Google Scholar 

  • Hill A (1980) Salt-water coupling in leaky epithelia. J Member Biol 56:177–182

    CAS  Google Scholar 

  • Hill BS, Hill AE (1978) Fluid transfer by necturus gall bladder epithelium as a function of osmolarity. Proc R Soc Lond 200:151–162

    CAS  Google Scholar 

  • Hille B (1992) Ionic Channels of Excitable Membranes. Sinauer Associates Inc., Sunderland, Massachusetts

    Google Scholar 

  • House CR (1974) Water transport in cells and tissues. Edward Arnold, London

    Google Scholar 

  • Hughes BA, Miller SS, Machen TE (1984) Effect of cyclic aMP on fluid absorption across the frog retinal pigment epithelium. Measurements in the open circuit state. J Gen Physiol 83:875–899

    PubMed  CAS  Google Scholar 

  • Ikonomov O, Simon MX, Frömter E (1985) Electrophysiological studies on lateral intercellular spaces of Necturus gallbladder epithelium. Pflüg Arch 403:301–307

    CAS  Google Scholar 

  • Ishibashi K, Kuwahara M, Gu Y, Kageyama Y, Tohsaka A, Suzuki F, Marumo F, Sasaki S (1997) Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea. J Biol Chem. 272:20782–20786

    PubMed  CAS  Google Scholar 

  • Kornblatt JA (1998) The water channel of cytochrome c oxidase: inferences from inhibitor studies. Biophysical Journal 75:3127–3134

    PubMed  CAS  Google Scholar 

  • Kornblatt JA, Hoa GHB (1990) A nontraditional role for water in the cytochrome c oxidase reaction. Biochem 29:9370–9376

    Google Scholar 

  • Kornblatt JA, Kornblatt MJ, Rajotte I, Hoa GHB, Kahn PC (1998) Thermodynamic volume cycles for electron transfer in the cytochrome c oxidase and for the binding of cytochrome c to cytochrome c oxidase. Biophys J 75:435–444

    PubMed  CAS  Google Scholar 

  • Kramhøft B, Lambert IH, Hofmann EK, Jørgensen F (1986) Activation of Cl dependent K transport in Ehrlich ascites tumor cells. Am J Physiol 251:C369–C379

    PubMed  Google Scholar 

  • Kregonow FM (1971) The response of duck erythrocytes to nonhemolytic hypotonic media. J Gen Physiol 58:372–395

    Google Scholar 

  • Kuriyama H, Kawamoto S, Ishida N, Ohno I, Mita S, Matsuzawa Y, Matsubara K, Okubo K (1997) Molecular cloning and expression of a novel human aquaporin from adipose tisue with glycerol permeability. Biochem Biophys Res Com 241:53–58

    PubMed  CAS  Google Scholar 

  • laCour M, Lin H, Kenyon E, Miller SS (1994) Lactate transport in freshly isolated human fetal retinal pigment epithelium. Invest Ophthalmol Vis Sci 35:434–440

    CAS  Google Scholar 

  • Larson M, Spring KR (1984) Volume regulation by necturus gallbladder: basolateral KCl exit. J Membr Biol 81:219–232

    PubMed  CAS  Google Scholar 

  • Latorre R, Miller C (1983) Conduction and selectivity in potassium channels. J Membr Biol 71:11–30

    PubMed  CAS  Google Scholar 

  • Lauf PK, Bauer J, Adragna NC, Fujise H, Martin A, Zade-Oppen M, Ryu KH, Delpire E (1992) Erythrocyte K−Cl cotransport: properties and regulation. Am J Physiol 263:C917–C932

    PubMed  CAS  Google Scholar 

  • Loike JD, Hickman S, Kuang K, Xu M, Cao L, Vera JC, Silverstein SC, Fischbarg J (1996) Sodium-glucose cotransporters display sodium-and phlorizin-dependent water permeability. Am J Physiol 271:C1774–C1779

    PubMed  CAS  Google Scholar 

  • Loo DDF, Wright EM, Meinild A-K, Klaerke DA, Zeuthen T (1999a) commentary on “Epithelial Fluid Transport—A century of investigation”. News Physiol Sci 14:98–100

    PubMed  Google Scholar 

  • Loo DDF, Zeuthen T, Chandy G, Wright EM (1996) Cotransport of water by the Na+/glucose cotransporter. Proc Natl Acad Sci USA 93

    Google Scholar 

  • Loo DF, Hirayama BA, Meinild A-K, Chandy G, Zeuthen T, Wright E (1999b) Passive water and ion transport by cotransporters. J Physiol, in press

    Google Scholar 

  • Lubin M (1963) Cell potassium and the regulation of protein synthesis. In: Hoffman JF (ed) The Cellular Functions of Membrane Transport. Prentice-Hall Inc., Englewood Cliffs, New Jersey, pp 193–211

    Google Scholar 

  • Ludwig C (1861) Lehrbuch der Physiologie des Menschen. C.F. Wintersche Verlagshandlung, Leipzig und Heidelberg

    Google Scholar 

  • Ma T, Frigeri A, Hasegawa H, Verkman AS (1994) Cloning of a water channel homolog expressed in brain meningeal cells and kidney collecting duct that functions as a stilbene-sensitive glycerol transporter. J Biol Chem 269:21845–21849

    PubMed  CAS  Google Scholar 

  • Mackenzie B, Loo DDF, Wright EM (1998) Relationship between Na+/glucose cotransporter (SGLT1) currents and fluxes. J Membr Biol 162:101–106

    PubMed  CAS  Google Scholar 

  • Maffly RH, Leaf A (1959) The potential of water in mammalian tissues. J Gen Physiol 42:1257–1275

    PubMed  CAS  Google Scholar 

  • Marmor MF (1989) Mechanisms of normal retinal adhesion. In: Ryan SJ, Schachat AP, Murphy RB, et al (eds) Retina. Mosby, St. Louis, USA, pp 71–87

    Google Scholar 

  • Maurel C, Reizer J, Schroeder JI, Chrispeels MJ, Saier Jr MH (1994) Functional Characterization of the Escherichia coli Glycerol Facilitator, GlpF, in Xenopus Oocytes. J Biol Chem 269:11869–11872

    PubMed  CAS  Google Scholar 

  • Meinild A-K, Klaerke DA, Loo DDF, Wright EM, Zeuthen T (1998a) The human Na+/Glucose cotransporter is a molecular water pump. J Physiol 508.1:15–21

    PubMed  CAS  Google Scholar 

  • Meinild A-K, Klaerke DA, Zeuthen T (1998b) Bidirectional water fluxes and specificity for small hydrophilic molecules in aquaporins 0 to 5. J Biol Chem 273:32446–32451

    PubMed  CAS  Google Scholar 

  • Meinild A-K, Loo DFF, Pajor A, Zeuthen T, Wright EM (2000) Water transport by the renal Na+/Dicarboxylate Cotransporter. Am J Physiol (in press)

    Google Scholar 

  • Mitchell P (1957) A general theory of membrane transport from studies of bacteria. Nature 180:134–136

    PubMed  CAS  Google Scholar 

  • Mitchell P (1990) Osmochemistry of solute translocation. Res Microbiol 141:286–289

    PubMed  CAS  Google Scholar 

  • Nikaido H, Saier MH, Jr. (1992) Transport proteins in bacteria: Common themes in their design. Science 258:936–942

    PubMed  CAS  Google Scholar 

  • Parent L, Supplison S, Loo DDF, Wright EM (1992) Electrogenic properties of the cloned Na+/Glucose Cotransporter. J Member Biol 125:49–62

    CAS  Google Scholar 

  • Parsegian A, Rau D, Zimmerberg J (1993) Structural transitions induced by osmotic stress. In: Leopold AC (ed) Membranes, Metabolism, and Dry Organisms. Comstock Publishing Associates, London, pp 306–317

    Google Scholar 

  • Parsons DS, Wingate DL (1961) The effect of osmotic gradients on fluid transfer across rat intestine in vitro. Biochim Biophys Acta 46:170–183

    PubMed  CAS  Google Scholar 

  • Patlak CS, Goldstein DA, Hoffman JF (1963) The flow of solute and solvent across a two-membrane system. J Theor Biol 3:420–442

    Google Scholar 

  • Pedley TJ (1978) The development of osmotic flow through an unstirred layer. J Theor Biol 70:427–447

    PubMed  CAS  Google Scholar 

  • Pedley TJ (1983) Calculation of unstirred layer thickness in membrane transport experiments: a survey. Quart Rev Biophys 16:115–150

    CAS  Google Scholar 

  • Pedley TJ, Fischbarg J (1980) Unstirred layer effects in osmotic water flow across gallbladder epithelium. J Membr Biol. 54:89–102

    PubMed  CAS  Google Scholar 

  • Perry PB, O’Neill WC (1993) Swelling-activated K fluxes in vascular endothelial cells: volume regulation via K−Cl cotransport and K channels. Am J Physiol 265:C763–C769

    PubMed  CAS  Google Scholar 

  • Persson B-E, Spring KR (1982) Gallbladder epithelial cell hydraulic water permeability and volume regulation. J Gen Physiol 79:481–505

    PubMed  CAS  Google Scholar 

  • Preston GM, Carroll TP, Guggino WB, Agre P (1992) Appearance of water channels in zenopus oocytes expressing red cell CHIP28 protein. Science 256:385–389

    PubMed  CAS  Google Scholar 

  • Qian M, Haser R, Payan F (1995) Carbohydrate Binding Sites in a Pancreatic α-Amylase-Substrate Complex, Derived from X-ray Structure Analysis at 2.1 Å Resolution. Prot Sci 4:747–755

    CAS  Google Scholar 

  • Rand RP, Fuller NL (1992) Water as an inhibiting ligand in yeast hexokinase. Biophys J 61:A345

    Google Scholar 

  • Reid EW (1892) Report on experiments upon “absorbtion without osmosis”. Brit med J 1:323–326

    Google Scholar 

  • Reid EW (1901) Transport of fluid by certain epithelia. J Physiol 26:436–444

    PubMed  CAS  Google Scholar 

  • Reuss L (1983) Basolateral KCl co-transport in a NaCl-absorbing epithelium. Nature 305:723–726

    PubMed  CAS  Google Scholar 

  • Reuss L (1985) Changes in cell volume measured with an electrophysiologic technique. Proc Natl Acad Sci 82:6014–6018

    PubMed  CAS  Google Scholar 

  • Sasaki Sea (1988) KCl co-transport across the basolateral membrane of rabbit renal proximal straight tubules. J Clin Invest. 81:194–199

    Google Scholar 

  • Schnermann J, Chou C-L, Ma T, Traynor T, Knepper MA, Verkman AS (1998) Defective proximal tubular fluid reabsorbtion in transgenic aquaporin-1 null mice. Proc Natl Acad Sci USA 95:9660–9664

    PubMed  CAS  Google Scholar 

  • Schreiber R, Greger R, Nitschke R, Kunzelmann K (1997) Cystic fibrosis transmembrane conductance regulator activates water condutance in Xenopus oocytes. Pflüg Arch 434:841–847

    CAS  Google Scholar 

  • Shindo T, Spring KR (1981) Chloride movement across the basolateral membrane of proximal tubule cells. J Membr Biol. 58:35–42

    PubMed  CAS  Google Scholar 

  • Spring KR (1998) Routes and mechanism of fluid transport by epithelia. Ann Rev Physiol 60:105–119

    CAS  Google Scholar 

  • Spring KR (1999) Epithelial Fluid Transport—A Century of Investigation. News Physiol Sci 14:94–97

    Google Scholar 

  • Steinbach HB (1962) The prevalence of K. Perspect Biol Med 5:338–355

    PubMed  CAS  Google Scholar 

  • Steitz TA, Shoham M, Bennett WS, Jr. (1981) Structural dynamics of yeast hexokinase during catalysis. Phil Trans R Soc Lond 293:43–52

    CAS  Google Scholar 

  • Tsukaguchi H, Shayakul C, Berfer UV, Mackenzie B, Devidas S, Guggino WB, Van-Hoek AN, Hediger MA (1998) Molecular Characterization of a Broad Selectivity Neutral Solute Channel. J Biol Biochem 273:24737–24743

    CAS  Google Scholar 

  • Turk E, Kerner CJ, Lostao MP, Wright EM (1996) Membrane Topology of the Human Na+/Glucose Cotransporter SGLT1. J Biol Chem 271:1925–1934

    PubMed  CAS  Google Scholar 

  • White TW, Bruzzone R, Goocenough DA, Paul DL (1992) Mouse Cx50, a functional member of the connexin family of gap junction proteins, is the lens fiber protein MP70. Mol Biol Cell 3:711–720

    PubMed  CAS  Google Scholar 

  • Whittembury G, Hill BS (1982) Fluid reabsorption by Necturus proximal tubule perfused with solutions of normal and reduced osmolarity. Proc Roy Soc 215:411–431

    CAS  Google Scholar 

  • Wright EM, Loo DDF, Panayotova-Heiermann M, Lostao MP, Hirayama BH, Mackenzie B, Boorer K, Zampighi G (1994) ‘Active’ sugar transprot in eurkaryotes. J Exp Biol 196:197–212

    PubMed  CAS  Google Scholar 

  • Wright EM, Loo DDF, Turk E, Hirayama BA (1996) Sodium cotransporters. Curr Opin Cell Biol 8:468–473

    PubMed  CAS  Google Scholar 

  • Wright EM, Loo DDF, Panayotova-Heiermann M, Lostao MP, Hirayama BH, Tyrk E, Eskandari S, Lam JT (1998) Structure and function of the Na+/glucose cotransporter. Acta Physiol Scand Suppl 643:257–264

    PubMed  CAS  Google Scholar 

  • Wright EM, Wiedner G, Rumrich G (1977) Fluid secretion by the frog choroid plexus. Exp Eye Res Suppl 25:149–155

    CAS  Google Scholar 

  • Yang B, Verkman AS (1997) Water and glycerol permeabilities of aquaporin 1–5 and MIP determined quantitatively by expression of epitope-tagged constructs in Xenopus oocytes. J Biol Chem 272:16140–14146

    PubMed  CAS  Google Scholar 

  • Zampighi GA, Kreman M, Boorer KJ, Loo DDF, Bezanilla F, Chandy G, Hall JE, Wright EM (1995) A Method for Determining the Unitary Functional Capacity of Cloned Channels and Transporters Expressed in Xenopus laevis oocytes. J Membr Biol 148:65–78

    PubMed  CAS  Google Scholar 

  • Zampighi GA, Kunig N, Loo DDF (1997) Structure and function of cell-to-cell channels purified from the lens and of hemichannels expressed in oocytes. In: Latorre R, Saez JC (eds) From Ion Channels to Cell-to-Cell Conversations. Plenum Press, pp 309–321

    Google Scholar 

  • Zeidel ML, Albalak A, Grossman E, Carruthers A (1992) Role of glucose carrier in human erythrocyte water permeability. Biochem 31:589–596

    CAS  Google Scholar 

  • Zeidel ML, Ambudkar SV, Smith BL, Agre P (1992) Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein. Biochem 31:7436–7440

    CAS  Google Scholar 

  • Zeuthen T (1981) Isotonic transport and intracellular osmolarity in the necturus gall-bladder epithelium. In: Ussing HH, Bindslev N, Lassen NA et al. (eds) Munksgaard, Copenhagen, Copenhagen, pp 313–331

    Google Scholar 

  • Zeuthen T (1982) Relations between intracellular ion activities and extracellular osmolarity in necturus gallbladder epithelium. J Membr Biol 66:109–121

    PubMed  CAS  Google Scholar 

  • Zeuthen T (1983) Ion activities in the lateral intercellular spaces of gallbladder epithelium transporting at low external osmolarities. J Membr Biol. 76113–122

    PubMed  CAS  Google Scholar 

  • Zeuthen T (1991b) Secondary active transport of water across ventricular cell membrane of choroid plexus epithelium of Necturus maculosus. J Physiol 444:153–173

    PubMed  CAS  Google Scholar 

  • Zeuthen T (1991a) Water permeability of ventricular cell membrane in choroid plexus epithelium from necturus maculosus. Journal of Physiology 444:133–151

    PubMed  CAS  Google Scholar 

  • Zeuthen T (1992) From contractile vacuole to leaky epithelia. Biophys Biochem Acta 1113:229–258

    CAS  Google Scholar 

  • Zeuthen T (1993) Low reflection coefficient for KCl in an epithelial membrane. In: Ussing HH, Fischbarg J, Sten-Knudsen O et al. (eds) Isotonic Transport in Leaky Epithelia. Munksgaard, Copenhagen, pp 298–307

    Google Scholar 

  • Zeuthen T (1994) Cotransport of K+, Cl− and H2O by membrane proteins from choroid plexus epithelium of Necturus maculosus. J Physiol 478:203–219

    PubMed  CAS  Google Scholar 

  • Zeuthen T (1995) Molecular mechanisms for passive and active transport of water. Int Rev Cyt 160:99–161

    CAS  Google Scholar 

  • Zeuthen T (1996) Molecular Mechanisms of Water Transport. Springer, Berlin, R.G. Landes Company, Texas

    Google Scholar 

  • Zeuthen T, Hamann S, La Cour M (1996) Cotransport of H+, lactate and H2O by membrane proteins in retinal pigment epithelium of bullfrog. J Physiol 497:3–17

    PubMed  CAS  Google Scholar 

  • Zeuthen T, Klaerke DA (1999) Transport of water and glycerol in aquaporin 3 is gated by H+. J Biol Chem 274:21631–21636

    PubMed  CAS  Google Scholar 

  • Zeuthen T, Meinild A-K, Klaerke DA, Loo DDF, Wright EM, Belhage B, Litman T (1997) Water transport by the Na+/glucose cotransporter under isotonic conditions. Biol Cell 89:307–312

    PubMed  CAS  Google Scholar 

  • Zeuthen T, Stein WD (1994) Co-transport of salt and water in membrane proteins: Membrane proteins as osmotic engines. J Membr Biol 137:179–195

    PubMed  CAS  Google Scholar 

  • Zimmerberg J, Bezanilla F, Parsegian VA (1990) Solute inaccessible aqueous volume changes during opening of the potassium channel of the squid giant axon. Biophys J 57:1049–1064

    PubMed  CAS  Google Scholar 

  • Zimmerberg J, Parsegian VA (1986) Polymer inaccessible volume changes during opening and closing of a voltage-dependent ionic channel. Nature 323:36

    PubMed  CAS  Google Scholar 

  • Zimmerman SB, Harrison B (1987) Macromolecular crowding increases binding of DNA polymerase to DNA: An adaptive effect. Proc Natl Acad Sci 84:1871–1875

    PubMed  CAS  Google Scholar 

  • Zimmerman SB, Minton AP (1993) Macromolecular crowding: Biochemical, biophysical, and physiological consequences. Ann Rev Biophys Biomol Struct 22:27–65

    CAS  Google Scholar 

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Zeuthen, T. (2000). Molecular water pumps. In: Reviews of Physiology Biochemistry and Pharmacology. Reviews of Physiology, Biochemistry and Pharmacology, vol 141. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0119578

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