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The Colloid Science of Lipids pp 40–46Cite as

A structural model for the human skin barrier

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Part of the book series: Progress in Colloid & Polymer Science ((PROGCOLLOID,volume 108))

Abstract

Based on the composition of lipids extracted from the horny layer of human skin a two phase structure organization has been proposed for the skin barrier. The dominant part represents lipids in crystalline (gel) state envisioned as domains surrounded by lipids in liquid crystalline state. On theoretical grounds this domain mosaic model can be shown to provide an effectively water tight skin barrier, still allowing a minute leakage of water necessary to keep the keratin of the cornecocytes hydrated to a level that ensures plasticity of the horney layer. Perturbing the liquid crystalline phase, e.g. by introduction of penetration enhancers, can be shown to cause an increase in transdermal transport by several orders of magnitude.

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Author information

Authors and Affiliations

  1. EDRG, Medical Biophysics, MBB, Karolinska Institute, S-171 77, Stockholm, Sweden

    B. Forslind (Associate Professor) & L. Norlén

  2. Food Technology, Lund University, Lund and Bioglan AB, Malmö, Sweden

    J. Engblom

Authors
  1. B. Forslind
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  2. L. Norlén
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  3. J. Engblom
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Corresponding author

Correspondence to B. Forslind .

Editor information

B. Lindman B. W. Ninham

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© 1998 Dr. Dietrich Steinkopff Verlag GmbH & Co. KG

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Forslind, B., Norlén, L., Engblom, J. (1998). A structural model for the human skin barrier. In: Lindman, B., Ninham, B.W. (eds) The Colloid Science of Lipids. Progress in Colloid & Polymer Science, vol 108. Steinkopff. https://doi.org/10.1007/BFb0117959

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  • DOI: https://doi.org/10.1007/BFb0117959

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  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-7985-1112-5

  • Online ISBN: 978-3-7985-1655-7

  • eBook Packages: Springer Book Archive

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