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Action of polyvinyl pyrrolidone on the interaction of polysilicic acid with human serum albumin monolayers

  • J. Miñones
  • E. Iribarnegaray
  • S. García Fernández
  • P. Sanz Pedrero
Conference paper
Part of the Progress in Colloid & Polymer Science book series (PROGCOLLOID, volume 58)

Abstract

The interaction between polysilicic acid and human serum albumin monolayers can be inhibited by the action of polyvinyl pyrrolidone (PVP). This effect is produced by a competition between the polymer and the protein for the silanol groups of polysilicic acid. The results obtained show that in a substrate containing 0.30 g/l of SiO2 in form of polysilicic acid a concentration of 80 mg/l of PVP is enough to produce the inhibition of the silicic-protein interaction.

The inhibition caused by a certain quantity of PVP depends on the polymerization time of silicic acid and on the time elapsed from the moment in which the acid is added to the substrate until the record of the isotherms starts.

Keywords

Silicic Acid Silanol Group Polymerization Time Sodium Silicate Solution Hysteresis Cycle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1).
    Vigliani, E. C. and B. Pernis, J. Occup. Med. 1, 319–1329 (1959).Google Scholar
  2. 2).
    Miñones, J., S. García Fernández and P. Sanz Pedrero, in Proc. First. Eur. Biophys. Congr., Vol. I, pp. 203–207 (Wien, 1971).Google Scholar
  3. 3).
    Miñones, J., S. García Fernández, E. Iribarnegaray and P. Sanz Pedrero, J. Colloid Interface Sci. 42, 503–515 (1973).CrossRefGoogle Scholar
  4. 4).
    Heppleston, A. G., in Inhaled Particles III, pp. 357 to 369 (1971).Google Scholar
  5. 5).
    Schlipköter, H. W. and A. Brockhaus, Klin. Wschr. 39, 1182–1189 (1961).CrossRefGoogle Scholar
  6. 6).
    González Carrero, J., Pharm. Acta. Helvet. 38, 529 to 538 (1963).Google Scholar
  7. 7).
    González Carrero, J., Med. Segur. Trab. 20, no 80, 5–24 (1972).Google Scholar
  8. 8).
    Strickland, J. D. H., J. Amer. Chem. Soc. 74, 868 to 871 (1952).Google Scholar
  9. 10).
    Weitz, E., H. Franck and M. Schuchard, Chem. Z. 74, 256–257 (1950).Google Scholar
  10. 11).
    Alexander, G. B., J. Amer. Chem. Soc. 75, 5655 to 5657 (1953).Google Scholar
  11. 12).
    Dervichian, D. G., Kolloid-Z. 126, 15–20 (1952).CrossRefGoogle Scholar
  12. 13).
    Miñones, J., E. Iribarnegaray, S. García Fernández and P. Sanz Pedrero, Colloid & Polymer Sci. 250, 318–324 (1972).Google Scholar

Copyright information

© Dr. Dietrich Steinkopff Verlag GmbH & Co. KG 1975

Authors and Affiliations

  • J. Miñones
    • 1
  • E. Iribarnegaray
    • 1
  • S. García Fernández
    • 1
    • 2
  • P. Sanz Pedrero
    • 1
  1. 1.Department of Physical Chemistry, Faculty of PharmacyUniversity of Santigo de CompostelaSpain
  2. 2.Department of Physical Chemistry. Faculty of PharmacyUniversity of BarcelonaSpain

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