Abstract
We have studied the interactions between hydroxypropylmethyl cellulose (HMPC) and the surface active substances sodium dodecylsulfate (SDS), cetyltrimethylammonium bromide (C16TAB), sodium cholate (SC0 and sodium taurocholate (STC) in solution. Cloud point (CP) measurements showed that the CP was lowered when surfactant was added at concentrations below the normal CMC, the effect being most pronounced for SDS and least for the bile salts. The effect could be enhanced with low concentrations of added salt. Experiments with ion-selective electrodes and conductdivity showed that the process was cooperative, and that small aggregates with low surface charge density were formed. The aggregates were highly hydrophobic as determined with fluorescence probe studies. The aggregation number of the SDS/HPMC aggregate was determined to be 30 with fluorescence quenching. The importance of the results from a pharmaceutical formulation point of view was emphasized.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Robb ID (1981) In: Lucasseu-Reynders EH (ed) Anionic surfactants in Physical Chemistry of Surfactant Action. Marcel Dekker, New York, pp 109–142
Nagarajan R (1985) Colloids and Surfaces 13:1–17
Goddard ED (1985) Colloids and Surfaces 13:255–300
Ruckenstein E, Huber G, Hoffmann H ((1987) Langmuir 3:382–387
Goddard ED (1990) J Soc Cosmet Chem 41:23–49
Almgren M, Löfroth J-E (1981) J Colloid Interface Sci 81:486–499
Carlsson A, Karlström G, Lindman B, Stenberg O (1988) Colloid Polym Sci 266:1031–1036
Karlström G, Carlsson A, Lindman B (1990) J Phys Chem 94:5005–5015
Gilányi T (1973) Acta Chem Scand 27:729–731
Zana R (1980) J Colloid Interface Sci 78:330–337
Kalyanasundaram K, Thomas JK (1977) J Am Chem Soc 99:2039–2044
Turro NJ, Baretz BH, Kuo P-L (1984) Macromolecules 17:1321–1324
Lissi EA, Abuin E (1985) J Colloid Interface Sci 105:1–6
Author information
Authors and Affiliations
Editor information
Rights and permissions
Copyright information
© 1991 Dr. Dietrich Steinkopff Verlag GmbH & Co. KG
About this paper
Cite this paper
Löfroth, J.E., Johansson, L., Norman, A.C., Wettström, K. (1991). Interactions between surfactants and polymers. I: HPMC. In: Corti, M., Mallamace, F. (eds) Trends in Colloid and Interface Science V. Progress in Colloid & Polymer Science, vol 84. Steinkopff, Heidelberg. https://doi.org/10.1007/BFb0115938
Download citation
DOI: https://doi.org/10.1007/BFb0115938
Published:
Publisher Name: Steinkopff, Heidelberg
Print ISBN: 978-3-662-16029-9
Online ISBN: 978-3-7985-1685-4
eBook Packages: Springer Book Archive