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Gels pp 118-122 | Cite as

Hydrogel medicinal systems of prolonged action

  • Yu. Samchenko
  • Z. Ulberg
  • N. Pertsov
Conference paper
Part of the Progress in Colloid & Polymer Science book series (PROGCOLLOID, volume 102)

Abstract

The copolymerization of acrylamide with acrylic acid has allowed to synthesize therapeutic contact lenses, fitst of all, antiglaucoma ones. The reached considerable prolongation of the release of miotic reagent pilocarpine from such lenses (and other polymer carriers) is explained by the formation of the ionic bonds between polyionic hydrogel and medicine substance being nitrogen base. Slowly running hydrolysis of the formed ionic complex is accompanied by gradual release of the drug.

Sharp change in an amount of the water, retained by the hydrogels, at small pH change allows to control the process of transport and release of the medicines introduced in the polymer carrier.

Key words

Hydrogel copoly-merization pilocarpin ophthalmology prologed release 

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Copyright information

© Dr. Dietrich Steinkopff Verlag GmbH & Co. KG 1996

Authors and Affiliations

  • Yu. Samchenko
    • 1
  • Z. Ulberg
    • 1
  • N. Pertsov
    • 1
  1. 1.Institute of Biocolloidal ChemistryNational Academy of Sciences of UkraineKyivUkraine

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