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Scope and limitation of single electron transfer in biology

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Biochemistry

Part of the book series: Structure and Bonding ((STRUCTURE,volume 48))

Abstract

This article is thought to be a supplement to an earlier one “Mechanism of Hydrogen Transfer in Redox Enzymes”33). Most of the basic concepts and hypotheses put forward then, are still valid. Substantial new evidence supporting our views has been advanced since then. The new data presented here concern modified or as we call them “mutilated flavins”, namely 5-deaza- and 5-thiaflavin, which upon incorporation into apoflavoprotein retain some, but not all of the activities encountered with the native flavoproteins.

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References

  1. Biellmann, C. F., Jung, M. J.: FEBS-Letters 7, 199 (1970)

    Article  CAS  Google Scholar 

  2. Blankenhorn, G.: Eur. J. Biochem. 50, 351 (1975)

    Article  CAS  Google Scholar 

  3. Blankenhorn, G.: Eur. J. Biochem. 67, 67 (1976)

    Article  CAS  Google Scholar 

  4. Blankenhorn, G., Moore, E. G.: J. Am. Chem. Soc. 102, 1092 (1980)

    Article  CAS  Google Scholar 

  5. Bors, W., Michel, C., Saran, M.: Eur. J. Biochem. 95, 621 (1979)

    Article  CAS  Google Scholar 

  6. Bright, H. J., Porter, D. J. T.: In: The Enzymes, Vol. XII B. P. D. Boyer (ed.), p. 421, New York: Academic Press 1975

    Google Scholar 

  7. Brown, H. C., Krishnamurthy, S.: Tetrahedron 35, 567 (1979)

    Article  CAS  Google Scholar 

  8. Buddecke, E.: Grundriß der Biochemie, 4th ed., p. 44, Berlin: de Gruyter 1974

    Google Scholar 

  9. Burnett, R. W., Underwood, A. L.: Biochemistry 7, 3328 (1968)

    Article  CAS  Google Scholar 

  10. Caughey, W. S., Choc, M. G., Houtchens, R. A.: In: Biochemical and Clinical Aspects of Oxygen. W. S. Caughey (ed.), p. 1, New York: Academic Press 1979

    Google Scholar 

  11. Cava, M. P., Mitchell, M. J.: Cyclobutadiene and Related Compounds, New York: Academic Press 1967

    Google Scholar 

  12. Chen, S. J., Fowler, F. W.: J. Org. Chem. 35, 3987 (1970)

    Article  CAS  Google Scholar 

  13. Chen, S. J., Fowler, F. W.: J. Org. Chem. 36, 4025 (1971)

    Article  Google Scholar 

  14. Dixon, M., Webb, E. L.: Enzymes, 3rd ed., p. 474, London: Longmann 1979

    Google Scholar 

  15. Draganic, I. C., Draganic, Z. D.: The Radiation Chemistry of Water, p. 70, New York — London: Academic Press 1971

    Google Scholar 

  16. Duchstein, H.-J., Fenner, H., Hemmerich, P., Knappe, W.-R.: Eur. J. Biochem. 95, 167 (1979)

    Article  CAS  Google Scholar 

  17. Dudley, K. H., Ehrenberg, A., Hemmerich, P., Müller, F.: Helv. Chim. Acta 47, 1354 (1964)

    Article  CAS  Google Scholar 

  18. Ehrenberg, A., Müller, F., Hemmerich, P.: Eur. J. Biochem. 2, 286 (1967)

    Article  CAS  Google Scholar 

  19. Eisner, U., Kuthan, J.: Chem. Rev. 72, 1 (1972)

    Article  CAS  Google Scholar 

  20. Fee, J. A.: Struct. Bonding (Berlin) 23, 1 (1975)

    Article  CAS  Google Scholar 

  21. Fenner, H., Grauert, R., Hemmerich, P., Michel, H., Massey, V.: Eur. J. Biochem. 95, 183 (1979)

    Article  CAS  Google Scholar 

  22. Frisell, W. R., Chung, C. W., Mackenzie, C. G.: J. Biol. Chem. 234, 1297 (1959)

    CAS  Google Scholar 

  23. Geißler, J., Hemmerich, P.: FEBS-Letters, 126, 152 (1981)

    Article  Google Scholar 

  24. Ghisla, S., Hartmann, U., Hemmerich, P., Müller, F.: Liebigs Ann. Chem. 1973, 1388

    Google Scholar 

  25. Ghisla, S., Massey, V., Lhoste, J.-M., Mayhew, S. G.: Biochemistry 13, 589 (1974)

    Article  CAS  Google Scholar 

  26. Ghisla, S., Massey, V.: In: Mechanisms of Oxidizing Enzymes. T. P. Singer, R. Ondarza (ed.), p. 55, Amsterdam: Elsevier 1978

    Google Scholar 

  27. Ghisla, S., Olson, S. T., Massey, V., Lhoste, J.-M.: Biochemistry 18, 4724 (1979)

    Article  Google Scholar 

  28. Ghisla, S., Wenz, A., Thorpe, C.: In: Enzyme Inhibitors. U. Brodbeck (ed.), p. 43, Weinheim: Verlag Chemie 1980

    Google Scholar 

  29. Goldberg, M., Pecht, I., Kramer, H. E. A., Traber, R., Hemmerich, P.: Biochim. Biophys. Acta, 673, 570 (1981)

    CAS  Google Scholar 

  30. Hayon, E., Simic, M.: Acc. Chem. Res. 7, 114 (1974)

    Article  CAS  Google Scholar 

  31. Hemmerich, P., Prijs, B., Erlenmeyer, H.: Helv. Chim. Acta 43, 372 (1960)

    Article  CAS  Google Scholar 

  32. Hemmerich, P., Nagelschneider, G., Veeger, C.: FEBS-Letters 8, 69 (1970)

    Article  CAS  Google Scholar 

  33. Hemmerich, P., Schuman-Jorns, M.: In: Enzymes: Structure and Function. J. Drenth, R. A. Oosterbaan, C. Veeger (ed.), p. 95, Amsterdam: North-Holland Pub. Corp. 1972

    Google Scholar 

  34. Hemmerich, P., Bhaduri, A. P., Blankenhorn, G., Brüstlein, M., Haas, W., Knappe, W.-R.: In: Oxidases and Related Redox Systems. T. E. King, H. S. Mason, M. Morrison (ed.), p. 3, Baltimore: University Park Press 1973

    Google Scholar 

  35. Hemmerich, P., Haas, W.: In: Reactivity of Flavins. K. Yagi (ed.), p. 1, Tokyo: University Press, 1975

    Google Scholar 

  36. Hemmerich, P.: In: Progress in the Chemistry of Organic Natural Products. W. Herz, H. Grisebach, G. W. Kirby (ed.), 33, 451 (1976)

    Google Scholar 

  37. Hemmerich, P.: Adv. Chem. Ser. 162, 312 (1977)

    Article  CAS  Google Scholar 

  38. Hemmerich, P., Massey, V.; Fenner, H.: FEBS-Letters 84, 5 (1977)

    Article  CAS  Google Scholar 

  39. Hemmerich, P., Wessiak, A.: In: Biochemistry and Clinical Aspects of Oxygen. W. S. Caughey (ed.), p. 491, New York: Academic Press 1979

    Google Scholar 

  40. Hemmerich, P., Knappe, W.-R., Kramer, H. E. A., Traber, R.: Eur. J. Biochem. 104, 511 (1980)

    Article  CAS  Google Scholar 

  41. Hemmerich, P., Massey, V.: In: Oxidases and Related Redox Systems. T. E. King, H. S. Mason, M. Morrison (ed.) in press 1981

    Google Scholar 

  42. Hutton, R. F., Westheimer, F. H.: Tetrahedron 3, 73 (1958)

    Article  CAS  Google Scholar 

  43. Jagow, G. v., Engel, W. D.: Angew. Chem. 92, 684 (1980)

    Article  Google Scholar 

  44. Jefcoate, C. R., Ghisla, S., Hemmerich, P.: J. Chem. Soc. (C) 1971, 1689

    Google Scholar 

  45. Jonah, C. D., Miller, J. R., Matheson, M. S.: J. Phys. Chem. 81, 1618 (1977)

    Article  CAS  Google Scholar 

  46. Karlson, P.: Kurzes Lehrbuch der Biochemie für Mediziner und Naturwissenschaftler, 8th ed., p. 89, Stuttgart: Thieme Verlag 1972

    Google Scholar 

  47. Kierkegaard, P., Norrestam, R., Werner, P., Csöregh, I., Glehn, M. v., Karlsson, R., Leijonmarck, M., Rönnquist, O., Stennesland, B., Tillberg, O., Torbjörnsson, L.: In: Flavins and Flavoproteins. H. Kamin (ed.), p. 1, Baltimore: University Park Press 1971

    Google Scholar 

  48. Knappe, W.-R., Hemmerich, P.: Liebigs Ann. Chem. 1976, 2037

    Google Scholar 

  49. Kuhn, R., Boulanger, P.: Ber. 69, 1557 (1936)

    Google Scholar 

  50. Kuhn, R., Ströbele, R.: Ber. 70, 753 (1937)

    Google Scholar 

  51. Lambeth, D. O., Palmer, G.: J. Biol. Chem. 248, 6095 (1973)

    CAS  Google Scholar 

  52. Land, E. J., Swallow, A. J.: Biochemistry 8, 2117 (1969)

    Article  CAS  Google Scholar 

  53. Lehninger, A. L.: Biochemie, 2nd ed., p. 276, 399, Weinheim: Verlag Chemie 1977

    Google Scholar 

  54. Ludwig, M. L., Burnett, R. M., Darling, C. D., Jordan, S. R., Kendall, D. S., Smith, W. W.: In: Flavins and Flavoproteins. T. P. Singer (ed.), p. 393, Amsterdam — Oxford — New York: Elsevier: North-Holland 1976

    Google Scholar 

  55. Mahler, H. R., Cordes, E. H.: Biological Chemistry, 2nd ed., p. 413, New York: Harper & Row 1971

    Google Scholar 

  56. Malmström, B. G., Andrèasson, L.-E., Reinhammar, B.: In: The Enzymes, Vol. XII B. P. D. Boyer (ed.), p. 507, New York: Academic Press 1975

    Google Scholar 

  57. Massey, V., Palmer, G.: Biochemistry 5, 3181 (1966)

    Article  CAS  Google Scholar 

  58. Massey, V., Ghisla, S.: Ann. N. Y. Acad. Sci. 227, 446 (1974)

    Article  Google Scholar 

  59. Massey, V., Hemmerich, P.: In: The Enzymes, Vol. XII, 3rd ed., P. D. Boyer (ed.), p. 191, New York: Academic Press 1975

    Google Scholar 

  60. Massey, V., Hemmerich, P.: Biochemistry 17, 9 (1978)

    Article  CAS  Google Scholar 

  61. Massey, V.: In: Biochemical and Clinical Aspects of Oxygen. W. S. Caughey (ed.), p. 477, New York: Academic Press 1979

    Google Scholar 

  62. Massey, V., Ghisla, S., Kieschke, K.: J. Biol. Chem. 255, 2796 (1980)

    CAS  Google Scholar 

  63. Massey, V., Hemmerich, P.: Biochem. Soc. Trans. Biochem. Rev. 8, 246 (1980)

    CAS  Google Scholar 

  64. Mayhew, S. G., Ludwig, M. L.: In: The Enzymes, Vol. XII B, 3rd ed. P. D. Boyer (ed.), p. 57, New York: Academic Press 1975

    Google Scholar 

  65. Mayhew, S. G., van Arem, E. J. F., Strating, M. J. J., Wassink, J. H.: In: Flavins and Flavoproteins. T. D. Singer (ed.), p. 411, Amsterdam — Oxford — New York: Elsevier, North-Holland 1976

    Google Scholar 

  66. Metzler, D. E.: Biochemistry, p. 464, New York: Academic Press 1977

    Google Scholar 

  67. Michaelis, L., Schubert, P. M., Smythe, C. V.: J. Biol. Chem. 116, 587 (1936)

    CAS  Google Scholar 

  68. Michaelis, L., Schwarzenbach, G. J.: J. Biol. Chem. 123, 527 (1938)

    CAS  Google Scholar 

  69. Mincey, T., Tayrien, G., Mildvan, A. S., Abeles, R. H.: Proc. Natl. Acad. Sci. USA 77, 7099 (1980)

    Article  CAS  Google Scholar 

  70. Müller, F., Massey, V.: J. Biol. Chem. 244, 4007 (1969)

    Google Scholar 

  71. Müller, F., Massey, V., Heizmann, C., Hemmerich, P., Lhoste, J.-M., Gould, D. C.: Eur. J. Biochem. 9, 392 (1969)

    Article  Google Scholar 

  72. Müller, F., Brüstlein, M., Hemmerich, P., Massey, V., Walker, W.: Eur. J. Biochem. 25, 573 (1972)

    Article  Google Scholar 

  73. Palmer, G., Müller, F., Massey, V.: In: Flavins and Flavoproteins. H. Kamin (ed.), p. 123, Baltimore: University Park Press 1971

    Google Scholar 

  74. Pfleiderer, W., Mengel, R., Hemmerich, P.: Chem. Ber. 104, 2273 (1971)

    Article  CAS  Google Scholar 

  75. Schmidt, R. R.: Angew. Chem. 87, 603 (1975)

    Article  CAS  Google Scholar 

  76. Schug, C.: Diploma Thesis, University of Constance (1978)

    Google Scholar 

  77. Stewart, R., Norris, D. J.: J. C. S. Perkin II, 1978, 246

    Google Scholar 

  78. Stryer, L.: Biochemie, p. 180, Braunschweig: Vieweg 1979

    Google Scholar 

  79. Tauscher, L., Ghisla, S., Hemmerich, P.: Helv. Chim. Acta, 56, 630 (1973)

    Article  CAS  Google Scholar 

  80. Vaish, S. P., Tollin, G.: Bioenergetics 2, 61 (1971)

    Article  CAS  Google Scholar 

  81. Van Dijk, C., Veeger, C.: Eur. J. Biochem. 114, 209 (1981)

    Article  Google Scholar 

  82. Vinogradov, S. N., Linnell, R. H.: Hydrogen Bonding. New York: Van Nostrand Reinhold Company 1971

    Google Scholar 

  83. Visser, A. J. W. G., Müller, F.: Helv. Chim. Acta 62, 593 (1979)

    Article  CAS  Google Scholar 

  84. Walker, W., Hemmerich, P., Massey, V.: Helv. Chim. Acta 50, 2269 (1967)

    Article  CAS  Google Scholar 

  85. Walker, W., Hemmerich, P., Massey, V.: Eur. J. Biochem. 621, 166 (1959)

    Google Scholar 

  86. Wallenfels, K., Diekmann, K.: Liebigs Ann. Chem. 621, 166 (1959)

    Article  CAS  Google Scholar 

  87. Walsh, C.: Enzymatic Reaction Mechanisms, p. 427 ff. San Fransisco: W. H. Freeman 1979

    Google Scholar 

  88. Walsh, C.: Acc, Chem. Res. 13, 148 (1980)

    Article  CAS  Google Scholar 

  89. Wieland, H.: J. Chem. Soc. 1931, 1055

    Google Scholar 

  90. Molybdenum and Molybdenum-Containing Enzymes, Coughlan, M. (ed.), Oxford-New York: Pergamon Press 1980

    Google Scholar 

  91. Olson, J. S., Ballou, D. P., Palmer, G. and Massey, V.: J. Biol. Chem. 249, 4363 (1974)

    CAS  Google Scholar 

  92. Tischer, W., Bühler, M., Simon, H. and Hemmerich, P.: Z. Physiol. Chem. 361, 339 (1980)

    Google Scholar 

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Hemmerich, P., Massey, V., Michel, H., Schug, C. (1982). Scope and limitation of single electron transfer in biology. In: Biochemistry. Structure and Bonding, vol 48. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0111581

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  • DOI: https://doi.org/10.1007/BFb0111581

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