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Permeability changes in liposomes modeling the stratum corneum lipid composition caused by surfactants

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Trends in Colloid and Interface Science XI

Part of the book series: Progress in Colloid & Polymer Science ((PROGCOLLOID,volume 105))

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Abstract

The alterations caused by the surfactants sodium dedecyl sulfate (SDS); sodium dodecly ether sulfate (SDES); Triton X-100 (OP-10EO) and dodecyl betaine (D-Bet) in the permeability of liposomes formed by a lipid mixture modeling the stratum corneum composition (40% ceramides, 25% cholesterol, 25% plamitic acid and 10% cholesteryl sulfate) were investigated. The SC liposomes/surfactant sublytic interactions were mainly ruled by the action of surfactant monomers in all cases. The OP-10EO showed the highest ability to alter the permeability of bilayers and the highest affinity with these structures, whereas D-Bet showed the lowest tendencies. Although SDS and SDES exhibited similar activity at 50% CF release (similar Re values), the SDES appeared to be more active at 100% CF release, its affinity with bilayers being also increased. Different trends in the evolution of Re and K were observed when comparing the results obtained with those reported for phosphatidylcholine (PC) liposomes. Thus, whereas SC liposomes were more resistant to the action of surfactants, the surfactant affinity with SC bilayers was always greater than that reported for PC ones.

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J. B. Rosenholm B. Lindman P. Stenius

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© 1997 Steinkopff Verlag

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de la Maza, A., Coderch, L., Lopez, O., Baucells, J., Parra, J.L. (1997). Permeability changes in liposomes modeling the stratum corneum lipid composition caused by surfactants. In: Rosenholm, J.B., Lindman, B., Stenius, P. (eds) Trends in Colloid and Interface Science XI. Progress in Colloid & Polymer Science, vol 105. Steinkopff. https://doi.org/10.1007/BFb0110986

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  • DOI: https://doi.org/10.1007/BFb0110986

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  • Print ISBN: 978-3-7985-1086-9

  • Online ISBN: 978-3-7985-1660-1

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