Abstract
We present a new diagnostic method, based on optical measurements in the visible and near-infrared wavelength regime. This method has many advantages over current imaging and biopsy techniques. In order to understand and interpret the results of the measurements, a random-walk on a lattice is used to model photon diffusion in biological tissues. Applications of this method range from medicine (diagnosis of brain function (oxygenation) in neonates and early detection of breast tumors) to food science (non-destructive determination of fat and moisture content in Atlantic Salmon).
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Benaron, D.A., Stevenson, D.K. (1993): “Optical Time-of-Flight and Absorbance Imaging of Biologic Media”, Science, 259, 1463–1466
Ben-Avraham, D., Taitelbaum, H., Weiss, G.H. (1991): “Boundary conditions for a model of photon migration in a turbid medium,” Lasers Life Sci., 4, 29–36
Bonner, R.F., Nossal, R., Havlin, S., Weiss, G.H. (1987): “Model for photon migration in turbid biological media,” J. Opt. Soc. Am. A, 4, 423–432
Gandjbakhche, A.H., Taitelbaum, H., Weiss, G.H. (1993): “Random walk analysis of time-resolved transillumination measurements in optical imaging”, Physica A, 200, 212–221
Gandjbakhche, A.H., Weiss, G.H. (1995): “Random walk and diffusion-like models of photon migration in turbid media”, Prog. Opt., 34, 333–402
Gayen, S.K., Alfano, R.R. (1996): “Biomedical Imaging Techniques”, Optics and Photonics News, March 1996, pp. 17–22
de Haller, E.B. (1996): “Time-resolved transillumination and optical tomography”, J. Biomed. Opt., 1, 7–17
Havlin, S., Ben-Avraham, D. (1987): “Diffusion in disordered media”, Adv. Phys., 36, 695–798
Havlin, S., Kiefer, J.E., Trus, B., Weiss, G.H., Nossal, R. (1993): “Numerical method for studying the detectability of inclusions hidden in optically turbid tissue”, Appl. Opt., 32, 617–627
Hebden, J.C., Arridge, S.R., Delpy, D.T. (1997): “Optical Imaging in Medicine: I. Experimental Techniques”, Phys. Med. Biol., 42, 825–840
Arridge, S.R., Hebden, J.C. (1997): “Optical Imaging in Medicine: II. Modelling and Reconstruction”, ibid., 841–853
Nossal, R., Kiefer, J., Weiss, G.H., Bonner, R., Taitelbaum, H., Havlin, S. (1988): “Photon migration in layered media,” Appl. Opt., 27, 3382–3391
Rosen-Zvi, M., Taitelbaum, H. (1996): “Frequency-domain photon migration in two-layered tissues”, OSA TOPS on Biomedical Optical Spectroscopy and Diagnostics, 3, 101–104
Skov, L., Brun, N.C., Greisen, G. (1997): “Neonatal intensive care: Obvious yet difficult area for cerebral near IR spectroscopy”, J. Biomed. Opt., 2, 7–14
Taitelbaum, H., Havlin, S., Weiss, G.H. (1989): “Approximate theory of photon migration in a two-layer medium,” Appl. Opt., 28, 2245–2249
Taitelbaum, H. (1994): “Optical penetration depth in layered tissues”, OSA Proc. on Advances in Optical Imaging and Photon Migration, 21, 305–309
Selected Papers on TISSUE OPTICS: Applications in Medical Diagnostics and Therapy (1994): V.V. Tuchin, Ed., SPIE Milestone Series, MS102
Vered, R., Havlin, S., Taitelbaum, H. (1995): “Optical detection of hidden tumors”, SPIE Proc. 2389, 851–858
Weiss, G.H., Nossal, R., Bonner, R.F. (1989): “Statistics of penetration depth of photons re-emitted from irradiated tissue”, J. Mod. Opt., 36, 349–359
Wold, J.P., Isaksson, T. (1997): “Non-destructive determination of fat and moisture in whole Atlantic salmon by near-infrared diffuse spectroscopy”, J. Food Sci., 62, 734–736
Yodh, A., Chance, B. (1995): “Spectroscopy and Imaging with Diffusing Light”, Physics Today, March 1995, pp. 34–40
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Taitelbaum, H. (1999). Diagnosis using photon diffusion: From brain oxygenation to the fat of the atlantic salmon. In: Pękalski, A., Sznajd-Weron, K. (eds) Anomalous Diffusion From Basics to Applications. Lecture Notes in Physics, vol 519. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0106840
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DOI: https://doi.org/10.1007/BFb0106840
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