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Diagnosis using photon diffusion: From brain oxygenation to the fat of the atlantic salmon

  • H. Taitelbaum
Conference paper
Part of the Lecture Notes in Physics book series (LNP, volume 519)

Abstract

We present a new diagnostic method, based on optical measurements in the visible and near-infrared wavelength regime. This method has many advantages over current imaging and biopsy techniques. In order to understand and interpret the results of the measurements, a random-walk on a lattice is used to model photon diffusion in biological tissues. Applications of this method range from medicine (diagnosis of brain function (oxygenation) in neonates and early detection of breast tumors) to food science (non-destructive determination of fat and moisture content in Atlantic Salmon).

Keywords

Biological Tissue Average Path Length Turbid Medium Optical Biopsy Photon Trajectory 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Benaron, D.A., Stevenson, D.K. (1993): “Optical Time-of-Flight and Absorbance Imaging of Biologic Media”, Science, 259, 1463–1466CrossRefADSGoogle Scholar
  2. Ben-Avraham, D., Taitelbaum, H., Weiss, G.H. (1991): “Boundary conditions for a model of photon migration in a turbid medium,” Lasers Life Sci., 4, 29–36Google Scholar
  3. Bonner, R.F., Nossal, R., Havlin, S., Weiss, G.H. (1987): “Model for photon migration in turbid biological media,” J. Opt. Soc. Am. A, 4, 423–432ADSCrossRefGoogle Scholar
  4. Gandjbakhche, A.H., Taitelbaum, H., Weiss, G.H. (1993): “Random walk analysis of time-resolved transillumination measurements in optical imaging”, Physica A, 200, 212–221CrossRefADSGoogle Scholar
  5. Gandjbakhche, A.H., Weiss, G.H. (1995): “Random walk and diffusion-like models of photon migration in turbid media”, Prog. Opt., 34, 333–402CrossRefGoogle Scholar
  6. Gayen, S.K., Alfano, R.R. (1996): “Biomedical Imaging Techniques”, Optics and Photonics News, March 1996, pp. 17–22Google Scholar
  7. de Haller, E.B. (1996): “Time-resolved transillumination and optical tomography”, J. Biomed. Opt., 1, 7–17CrossRefGoogle Scholar
  8. Havlin, S., Ben-Avraham, D. (1987): “Diffusion in disordered media”, Adv. Phys., 36, 695–798CrossRefADSGoogle Scholar
  9. Havlin, S., Kiefer, J.E., Trus, B., Weiss, G.H., Nossal, R. (1993): “Numerical method for studying the detectability of inclusions hidden in optically turbid tissue”, Appl. Opt., 32, 617–627ADSCrossRefGoogle Scholar
  10. Hebden, J.C., Arridge, S.R., Delpy, D.T. (1997): “Optical Imaging in Medicine: I. Experimental Techniques”, Phys. Med. Biol., 42, 825–840CrossRefGoogle Scholar
  11. Arridge, S.R., Hebden, J.C. (1997): “Optical Imaging in Medicine: II. Modelling and Reconstruction”, ibid., 841–853CrossRefGoogle Scholar
  12. Nossal, R., Kiefer, J., Weiss, G.H., Bonner, R., Taitelbaum, H., Havlin, S. (1988): “Photon migration in layered media,” Appl. Opt., 27, 3382–3391ADSCrossRefGoogle Scholar
  13. Rosen-Zvi, M., Taitelbaum, H. (1996): “Frequency-domain photon migration in two-layered tissues”, OSA TOPS on Biomedical Optical Spectroscopy and Diagnostics, 3, 101–104Google Scholar
  14. Skov, L., Brun, N.C., Greisen, G. (1997): “Neonatal intensive care: Obvious yet difficult area for cerebral near IR spectroscopy”, J. Biomed. Opt., 2, 7–14CrossRefADSGoogle Scholar
  15. Taitelbaum, H., Havlin, S., Weiss, G.H. (1989): “Approximate theory of photon migration in a two-layer medium,” Appl. Opt., 28, 2245–2249ADSCrossRefGoogle Scholar
  16. Taitelbaum, H. (1994): “Optical penetration depth in layered tissues”, OSA Proc. on Advances in Optical Imaging and Photon Migration, 21, 305–309Google Scholar
  17. Selected Papers on TISSUE OPTICS: Applications in Medical Diagnostics and Therapy (1994): V.V. Tuchin, Ed., SPIE Milestone Series, MS102Google Scholar
  18. Vered, R., Havlin, S., Taitelbaum, H. (1995): “Optical detection of hidden tumors”, SPIE Proc. 2389, 851–858CrossRefADSGoogle Scholar
  19. Weiss, G.H., Nossal, R., Bonner, R.F. (1989): “Statistics of penetration depth of photons re-emitted from irradiated tissue”, J. Mod. Opt., 36, 349–359CrossRefADSGoogle Scholar
  20. Wold, J.P., Isaksson, T. (1997): “Non-destructive determination of fat and moisture in whole Atlantic salmon by near-infrared diffuse spectroscopy”, J. Food Sci., 62, 734–736CrossRefGoogle Scholar
  21. Yodh, A., Chance, B. (1995): “Spectroscopy and Imaging with Diffusing Light”, Physics Today, March 1995, pp. 34–40Google Scholar

Copyright information

© Springer-Verlag 1999

Authors and Affiliations

  • H. Taitelbaum
    • 1
  1. 1.Department of PhysicsBar-Ilan UniversityRamat-GanIsrael

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