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Apoptosis pp 75–105Cite as

The Bcl-2 gene family and apoptosis

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Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 62))

Abstract

Apoptosis, or programmed cell death, is an essential process for normal embryonic development, maintaining homeostasis in adult tissues, and suppressing carcinogenesis. The bcl-2 protein, discovered in association with follicular lymphoma, plays a prominent role in controlling apoptosis and enhancing cell survival in response to diverse apoptotic stimuli. The evolutionarily conserved bcl-2 protein is now recognized as being a member of a family of related proteins which can be categorized as death agonists or death antagonists. Progress in defining the role of bcl-2 and its family members in regulating apoptosis is rapidly advancing. This review describes, in detail, current bcl-2 family members and the possible mechanisms of function which allow the bcl-2 family of proteins to either promote or suppress cell death.

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Abbreviations

BH:

bcl-2 homology domain

DNA-PK:

DNA-dependent protein kinase

ER:

endoplasmic reticulum

ICE:

interleukin 1β converting enzyme

Ig:

immunoglobulin

KO:

knockout

NPC:

nuclear pore complex

PARP:

poly ADP-dependent polymerase

PEST:

proline-glutamate-serine-threonine

PKC:

protein kinase C

PT:

permeability transition

ROS:

reactive oxygen species

SM:

sphingomyelin

Smase:

sphingomyelinase

snRNPs:

small nuclear ribonuclear proteins

SV:

Sindbis virus

TG:

thapsigargin

TNF:

tumor necrosis factor α

TPA:

phorbol 12-myristate 13-acetate

UTR:

untranslated region

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Authors and Affiliations

  1. Department of Molecular Pathology, The University of Texas M.D. Anderson Cancer Center, 77030, Houston, TX

    E. M. Bruckheimer, S. H. Cho, M. Sarkiss & J. Herrmann

  2. Department of Molecular Pathology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Box 89, 77030, Houston, Texas

    T. J. McDonnell

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  1. E. M. Bruckheimer
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  2. S. H. Cho
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  3. M. Sarkiss
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  4. J. Herrmann
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  5. T. J. McDonnell
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M. Al-Rubeai (Volume Editor)

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© 1998 Springer-Verlag Berlin Heidelberg

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Bruckheimer, E.M., Cho, S.H., Sarkiss, M., Herrmann, J., McDonnell, T.J. (1998). The Bcl-2 gene family and apoptosis. In: Al-Rubeai, M. (eds) Apoptosis. Advances in Biochemical Engineering/Biotechnology, vol 62. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0102306

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  • DOI: https://doi.org/10.1007/BFb0102306

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-64153-7

  • Online ISBN: 978-3-540-69694-0

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