Detecting and inferring brain activation from functional MRI by hypothesis-testing based on the likelihood ratio

  • Dimitrios Ekatodramis
  • Gábor Székely
  • Guido Gerig
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 1496)


For the measure of brain activation in functional MRI many methods compute a heuristically chosen metric. The statistic of the underlying metric which is implicitly derived from the original assumption about the noise in the data, provides only an indirect way to the statistical inference of brain activation. An alternative procedure is proposed by presenting a binary hypothesis-testing approach. This approach treats the problem of detecting brain activation by directly deriving a test statistic based on the probabilistic model of the noise in the data. Thereby, deterministic and parameterized models for the hemodynamic response can be considered. Results show that time series models can be detected even if they are characterized by unknown parameters, associated with the unclear nature of the mechanisms that mediate between neuronal stimulation and hemodynamic brain response. The likelihood ratio tests proposed in this paper are very efficient and robust in making a statistical inference about detected regions of brain activation. To validate the applicability of the approach a simulation environment for functional MRI is used. This environment also serves as a testbed for comparative study and systematic tests.


Likelihood Ratio Test Hemodynamic Response False Alarm Probability Observe Time Series Generalize Likelihood Ratio Test 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Dimitrios Ekatodramis
    • 1
  • Gábor Székely
    • 1
  • Guido Gerig
    • 1
  1. 1.Communication Technology Laboratory ETH-ZentrumSwiss Federal Institute of TechnologyZurichSwitzerland

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