Automatic quantification of MS lesions in 3D MRI brain data sets: Validation of INSECT

  • Alex Zijdenbos
  • Reza Forghani
  • Alan Evans
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 1496)


In recent years, the quantitative analysis of MRI data has become a standard surrogate marker in clinical trials in multiple sclerosis (MS). We have developed INSECT (Intensity Normalized Stereotaxic Environment for Classification of Tissues), a fully automatic system aimed at the quantitative morphometric analysis of 3D MRI brain data sets. This paper describes the design and validation of INSECT in the context of a multi-center clinical trial in MS. It is shown that no statistically significant differences exist between MS lesion load measurements obtained with INSECT and those obtained manually by trained human observers from seven different clinical centers.


Multiple Sclerosis Magnetic Resonance Imaging Data Multiple Sclerosis Lesion Lesion Load Automatic Quantification 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Alex Zijdenbos
    • 1
  • Reza Forghani
    • 1
    • 2
  • Alan Evans
    • 1
  1. 1.Montreal Neurological InstituteMcConnell Brain Imaging CentreMontréalCanada
  2. 2.Department of Neurology and NeurosurgeryMontreal Neurological InstituteMontréalCanada

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