Abstract
In order to characterize the blood coagulolytic state, mathematical model was elaborated whose parameters represent biological activities non-approachable by classical biological tests. The experiments necessary for the parameters' estimation were easily carried out and a reliable estimation procedure was developped so as to render the method operational for current use in biological laboratories, 100 plasma samples from control and treated subjects were analysed and their parameters identified. By using statistical techniques on these results we validated our model and we showed that the model parameters, we estimated were more efficient than classical biological tests in the characterization of the coagulolytic state of control subjects and in the recognition of patients. An original method for diagnosis was derived. This study clearly shows the importance of an approach based on system modelling for the study of a complex biological system and the great interest of data analysis techniques in the analysis of the results with a view to diagnosis.
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Cheruy, A. (1982). Definition, estimation, statistical analysis of kinetical parameters of a biological systems with a view to aided diagnosis. In: Bensoussan, A., Lions, J.L. (eds) Analysis and Optimization of Systems. Lecture Notes in Control and Information Sciences, vol 44. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0044439
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DOI: https://doi.org/10.1007/BFb0044439
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