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Electrical breakdown, electropermeabilization and electrofusion

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Reviews of Physiology, Biochemistry and Pharmacology, Volume 105

Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology ((REVIEWS,volume 105))

Abstract

The considerable amount of activity in the field of electrofusion and electropermeabilization is very promising from the point of view of new insights into biomembranes and new technologies in the future for the production of new compounds and modification of cell systems for nutrition, energy production and the removal of waste products. It is particularly gratifying to see how basic science has provided the foundation for a useful technology, although in some cases the time needed to develop an application is very long. In other cases, it is necessary to overcome the difficulties posed by existing schools of thought which have been shown to be wrong. It is fascinating to observe the many developments and discoveries in the areas of physics, material science, space technology and electronics which are just waiting to be applied to biological systems. An increased interdisciplinary collaboration between physicists and biologists could provide considerable impetus to biology and its application in technology. However, this can only be achieved if basic research into biological membranes is accelerated. The techniques for electrical breakdown, electropermeabilization and electrofusion could be an important tool in this process, since we cannot rule out the possibility that the high electrical fields occurring naturally in the membrane play an important role in the selective transport of substances across the membrane as well as in natural regulatory processes.

This work was supported by grants from the BMFT, the DFVLR, and the Deutsche Forschungsgemeinschaft (SFB 176)

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  1. Lehrstuhl für Biotechnologie der Universität Würzburg, Röntgenring 11, 8700, Würzburg, Germany

    Ulrich Zimmermann

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  1. Ulrich Zimmermann
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© 1986 Springer-Verlag

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Zimmermann, U. (1986). Electrical breakdown, electropermeabilization and electrofusion. In: Reviews of Physiology, Biochemistry and Pharmacology, Volume 105. Reviews of Physiology, Biochemistry and Pharmacology, vol 105. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0034499

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  • DOI: https://doi.org/10.1007/BFb0034499

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