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Peptide toxins and potassium channels

  • Florian Dreyer
Chapter
Part of the Reviews of Physiology, Biochemistry and Pharmacology book series (volume 115)

Keywords

Potassium Channel Snake Venom Scorpion Venom Crude Venom Peptide Toxin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Abia A, Lobaton CD, Moreno A, Garcia-Sancho J (1986) Leiurus quinquestriatus venom inhibits different kinds of Ca2+-dependent K+ channels. Biochim Biophys Acta 856:403–407Google Scholar
  2. Alger BE, Williamson A (1988) A transient calcium-dependent potassium component of the epileptiform burst after-hyperpolarization in rat hippocampus. J Physiol (Lond) 399:191–205Google Scholar
  3. Anderson AJ (1985) The effects of protease inhibitor homologues from mamba snake venoms on autonomic neurotransmission. Toxicon 23:947–954Google Scholar
  4. Anderson AJ, Harvey AL (1988) Effects of the potassium channel blocking dendrotoxins on acetylcholine release and motor nerve terminal activity. Br J Pharmacol 93:215–221Google Scholar
  5. Anderson CS, MacKinnon R, Smith C, Miller C (1988) Charybdotoxin block of single Ca2+-activated K+ channels. Effects of channel gating, voltage, and ionic strength. J Gen Physiol 91:317–333Google Scholar
  6. Banks BEC, Brown C, Burgess GM, Burnstock G, Claret M, Cocks TM, Jenkinson DH (1979) Apamin blocks certain neurotransmitter-induced increases in potassium permeability. Nature 282:415–417Google Scholar
  7. Barrett JC, Harvey AL (1979) Effects of the venom of the green mamba, Dendroaspis angusticeps on skeletal muscle and neuromuscular transmission. Br J Pharmacol 67:199–205Google Scholar
  8. Baumann A, Grupe A, Ackermann A, Pongs O (1988) Structure of the voltage-dependent potassium channel is highly conserved from Drosophila to vertebrate central nervous system. EMBO J 7:2457–2463Google Scholar
  9. Benishin CG, Sorensen RG, Brown WE, Krueger BK, Blaustein MP (1988) Four polypeptide components of green mamba venom selectively block certain potassium channels in rat brain synaptosomes. Mol Pharmacol 34:152–159Google Scholar
  10. Benoit E, Dubois J-M (1986) Toxin I from the snake Dendroaspis polylepis polylepis: a highly specific blocker of one type of potassium channel in myelinated nerve fiber. Brain Res 377:374–377Google Scholar
  11. Bidard J-N, Gandolfo G, Mourre C, Gottesmann C, Lazdunski M (1987a) The brain response to the bee venom peptide MCD. Activation and desensitization of a hippocampal target. Brain Res 418:235–244Google Scholar
  12. Bidard J-N, Mourre C, Lazdunski M (1987b) Two potent central convulsant peptides, a bee venom toxin, the MCD peptide, and a snake venom toxin, dendrotoxin I, known to block K+ channels, have interacting receptor sites. Biochem Biophys Res Commun 143:383–389Google Scholar
  13. Black AR, Dolly JO (1986) Two acceptor sub-types for dendrotoxin in chick synpatic membranes distinguishable by β-bungarotoxin. Eur J Biochem 156:609–617Google Scholar
  14. Black AR, Breeze AL, Othman IB, Dolly JO (1986) Involvement of neuronal acceptors for dendrotoxin in its convulsive action in rat brain. Biochem J 237:397–404Google Scholar
  15. Black AR, Donegan CM, Denny BJ, Dolly JO (1988) Solubilization and physical characterization of acceptors for dendrotoxin and β-bungarotoxin from synaptic membranes of rat brain. Biochemistry 27:6814–6820Google Scholar
  16. Blatz AL, Magleby KL (1986) Single apamin-blocked Ca-activated K+ channels of small conductance in cultured rat skeletal muscle. Nature 323:718–720Google Scholar
  17. Bondy CA, Russel JT (1988) Dendrotoxin and 4-aminopyridine potentiate neurohypophysial hormone secretion during low frequency electrical stimulation. Brain Res 453:397–400Google Scholar
  18. Bourque CW (1988) Transient calcium-dependent potassium current in magnocellular neurosecretory cells of the rat supraoptic nucleus. J Physiol (Lond) 397:331–347Google Scholar
  19. Bourque CW, Brown DA (1987) Apamin and d-tubocurarine block the afterhyperpolarization of rat supraoptic neurosecretory neurons. Neurosci Lett 82:185–190Google Scholar
  20. Bräu ME, Dreyer F, Jonas P, Repp H, Vogel W (1990) A K+ channel in Xenopus nerve fibres selectively blocked by bee and snake toxins: binding and voltage-clamp experiments. J Physiol (Lond) 420:365–385Google Scholar
  21. Breithaupt H, Habermann E (1968) Mastzelldegranulierendes Peptid (MCD-Peptid) aus Bienengift: Isolierung, biochemische und pharmakologische Eigenschaften. Naunyn-Schmiedeberg's Arch Pharmacol 261:252–270Google Scholar
  22. Brown PD, Sepúlveda FV (1985) Potassium movements associated with amino acid and sugar transport in enterocytes from rabbit jejunum. J Physiol (Lond) 363:271–285Google Scholar
  23. Burgess GM, Claret M, Jenkinson DH (1981) Effects of quinine and apamin on the calcium-dependent potassium permeability of mammalian hepatocytes and red cells. J Physiol (Lond) 317:67–90Google Scholar
  24. Carbone E, Wanke E, Prestipino G, Possani LD, Maelicke A (1982) Selective blockage of voltage-dependent K+ channels by a novel scorpion toxin. Nature 296:90–91Google Scholar
  25. Carbone E, Prestipino G, Spadavecchia L, Franciolini F, Possani LD (1987) Blocking of the squid axon K+ channel by noxiustoxin: a toxin from the venom of the scorpion Centruroides noxius. Pflügers Arch 408:423–431Google Scholar
  26. Castle NA, Strong PN (1986) Identification of two toxins from scorpion (Leiurus quinquestriatus) venom which block distinct classes of calcium-activated potassium channel. FEBS Lett 209:117–121Google Scholar
  27. Castle NA, Haylett DG, Jenkinson DH (1989) Toxins in the characterization of potassium channels. Trends Neurosci 12:59–65Google Scholar
  28. Chang CC (1979) The action of snake venoms on nerve and muscle. In: Lee CY (ed) Snake venoms, chap 10. Springer, Berlin Heidelberg New York, pp 309–376 (Handbook of experimental pharmacology, vol 52)Google Scholar
  29. Chang CC, Su MJ (1980) Mutual potentiation, at nerve terminals, between toxins from snake venoms which contain phospholipase A activity: β-bungarotoxin, crotoxin, taipoxin. Toxicon 18:641–648Google Scholar
  30. Cherubini E, Ben Ari Y, Gho M, Bidard JN, Lazdunski M (1987) Long-term potentiation of synaptic transmission in the hippocampus induced by a bee venom peptide. Nature 328:70–73Google Scholar
  31. Cherubini E, Neuman R, Rovira C, Ben Ari Y (1988) Epileptogenic properties of the mast cell degranulating peptide in CA3 hippocampal neurones. Brain Res 445:91–100Google Scholar
  32. Chesnut TJ, Carpenter DO, Strichartz GR (1987) Effects of venom from Conus striatus on the delayed rectifier potassium current of molluscan neurons. Toxicon 25:267–278Google Scholar
  33. Chicchi GG, Gimenez-Gallego G, Ber E, Garcia ML, Winquist R, Cascieri MA (1988) Purification and characterization of a unique, potent inhibitor of apamin binding from Leiurus quinquestriatus hebraeus venom. J Biol Chem 263:10 192–10 197Google Scholar
  34. Cognard C, Traoré F, Potreau D, Raymond G (1984) Effects of apamin on the outward potassium current of isolated frog skeletal muscle fibres. Pflügers Arch 402:222–224Google Scholar
  35. Cook NS (1988) The pharmacology of potassium channels and their therapeutic potential. Trends Pharmacol Sci 9:21–28Google Scholar
  36. Cook NS, Haylett DG (1985) Effects of apamin, quinine and neuromuscular blockers on calcium-activated potassium channels in guinea-pig hepatocytes. J Physiol (Lond) 358:373–394Google Scholar
  37. Cook NS, Haylett DG, Strong PN (1983) High affinity binding of [125I]monoiodoapamin to isolated guinea-pig hepatocytes. FEBS Lett 152:265–269Google Scholar
  38. Costa M, Furness JB, Humphreys CMS (1986) Apamin distinguishes two types of relaxation mediated by enteric nerves in the guinea-pig gastrointestinal tract. Naunyn-Schmiedeberg's Arch Pharmacol 332:79–88Google Scholar
  39. Cruz LJ, Gray WR, Yoshikami D, Olivera BM (1985) Conus venoms: a rich source of neuroactive peptides. J Toxicol-Toxin Rev 4:107–132Google Scholar
  40. Den Hertog A (1981) Calcium and the alpha-action of catecholamines on guinea-pig taenia caeci. J Physiol (Lond) 316:109–125Google Scholar
  41. Dolly JO, Halliwell JV, Black JD, Williams RS, Pelchen-Matthews A, Breeze AL, Mahraban F, Othman IB, Black AR (1984) Botulinum neurotoxin and dendrotoxin as probes for studies on transmitter release. J Physiol (Paris) 79:280–303Google Scholar
  42. Dreyer F, Penner R (1987) The actions of presynaptic snake toxins on membrane currents of mouse motor nerve terminals. J Physiol (Lond) 386:455–463Google Scholar
  43. Dubois J-M (1981) Evidence for the existence of three types of potassium channels in the frog Ranvier node membrane. J Physiol (Lond) 318:297–316Google Scholar
  44. Dubois JM (1982) Capsaicin blocks one class of K+ channels in the frog node of Ranvier. Brain Res. 245:372–375Google Scholar
  45. Dufton MJ (1985) Proteinase inhibitors and dendrotoxins. Sequence classification, structural prediction and structure/activity. Eur J Biochem 153:647–654Google Scholar
  46. Field A, Jenkinson DH (1987) The effect of noradrenaline on the ion permeability of isolated mammalian hepatocytes, studied by intracellular recording. J Physiol (Lond) 392:493–512Google Scholar
  47. Fosset M, Schmid-Antomarchi H, Hugues M, Romey G, Lazdunski M (1984) The presence in pig brain of an endogenous equivalent of apamin, the bee venom peptide that specifically blocks Ca2+-dependent K+ channels. Proc Natl Acad Sci USA 81:7228–7232Google Scholar
  48. Galvan M, Behrends J (1985) Apamin blocks calcium-dependent spike after-hyperpolarization in rat sympathetic neurones. Pflügers Arch 403:R50Google Scholar
  49. Gater PR, Haylett DG, Jenkinson DH (1985) Neuromuscular blocking agents inhibit receptor-mediated increases in the potassium permeability of intestinal smooth muscle. Br J Pharmacol 86:861–868Google Scholar
  50. Gimenez-Gallego G, Navia MA, Reuben JP, Katz GM, Kaczorowski GJ, Garcia ML (1988) Purification, sequence, and model structure of charybdotoxin, a potent selective inhibitor of calcium-activated potassium channels. Proc Natl Acad Sci USA 85:3329–3333Google Scholar
  51. Goedert M, Hunter JC, Ninkovic M (1984) Evidence for neurotensin as a non-adrenergic, non-cholinergic neurotransmitter in guinea pig ileum. Nature 311:59–62Google Scholar
  52. Goh JW, Pennefather PS (1987) Pharmacological and physiological properties of the after-hyperpolarization current of bullfrog ganglion neurones. J Physiol (Lond) 394:315–330Google Scholar
  53. Gray WR, Olivera BM, Cruz LJ (1988) Peptide toxins from venomous Conus snails. Ann Rev Biochem 57:665–700Google Scholar
  54. Guggino SE, Guggino WB, Green N, Sacktor B (1987) Blocking agents of Ca2+-activated K+ channels in cultured medullary thick ascending limb cells. Am J Physiol 252:C128–C137Google Scholar
  55. Habermann E (1968) Biochemie, Pharmakologie und Toxikologie der Inhaltsstoffe von Hymenopterengiften. Rev Physiol Biochem Exp Pharmacol 60:220–325Google Scholar
  56. Habermann E (1972) Bee and wasp venoms. Science 177:314–322Google Scholar
  57. Habermann E (1977) Neurotoxicity of apamin and MCD peptide upon central application. Naunyn-Schmiedeberg's Arch Pharmacol 300:189–191Google Scholar
  58. Habermann E (1984) Apamin. Pharmacol Ther 25:255–270Google Scholar
  59. Habermann E, Fischer K (1979) Bee venom neurotoxin (apamin): iodine labeling and characterization of binding sites. Eur J Biochem 94:355–364Google Scholar
  60. Habermann E, Horvath E (1980) Localization and effects of apamin after application to the central nervous system. Toxicon 18:549–560Google Scholar
  61. Habermann E, Reiz K-G (1965) Ein neues Verfahren zur Gewinnung der Komponenten von Bienengift, insbesondere des zentralwirksamen Peptids Apamin. Biochem Z 341:451–466Google Scholar
  62. Halliwell JV, Othman IB, Pelchen-Matthews A, Dolly JO (1986) Central action of dendrotoxin: selective reduction of a transient K conductance in hippocampus and binding to localized acceptors. Proc Natl Acad Sci USA 83:493–497Google Scholar
  63. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch 391:85–100Google Scholar
  64. Harris JB (1985) Phospholipases in snake venoms and their effects on nerve and muscle. Pharmacol Ther 31:79–102Google Scholar
  65. Harvey AL, Anderson AJ (1985) Dendrotoxins: snake toxins that block potassium channels and facilitate neurotransmitter release. Pharmacol Ther 31:33–55Google Scholar
  66. Harvey AL, Gage PW (1981) Increase of evoked release of acetylcholine at the neuromuscular junction by a fraction from the venom of the eastern green mamba snake (Dendroaspis angusticeps). Toxicon 19:373–381Google Scholar
  67. Harvey AL, Karlsson E (1980) Dendrotoxin from the venom of the green mamba, Dendroaspis angusticeps. A neurotoxin that enhances acetylcholine release of neuromuscular junctions. Naunyn-Schmiedeberg's Arch Pharmacol 312:1–6Google Scholar
  68. Harvey AL, Karlsson E (1982) Protease inhibitor homologues from mamba venoms: facilitation of acetylcholine release and interactions with prejunctional blocking toxins. Br J Pharmacol 77:153–161Google Scholar
  69. Harvey AL, Anderson AJ, Karlsson E (1984a) Facilitation of transmitter release by neurotoxins from snake venoms. J Physiol (Paris) 79:222–227Google Scholar
  70. Harvey AL, Anderson AJ, Mbugua PM, Karlsson E (1984b) Toxins from mamba venoms that facilitate neuromuscular transmission. J Toxicol Toxin Rev 3:91–137Google Scholar
  71. Hermann A, Erxleben C (1987) Charybdotoxin selectively blocks small Ca-activated K channels in Aplysia neurons. J Gen Physiol 90:27–47Google Scholar
  72. Hermann A, Hartung K (1983) Ca2+ activated K+ conductance in molluscan neurones. Cell Calcium 4:387–405Google Scholar
  73. Hille B (ed) (1984) Ionic channels of excitable membranes. Sinauer, Sunderland MAGoogle Scholar
  74. Hodgkin AL, Huxley AF (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol (Lond) 117:500–544Google Scholar
  75. Hoshi T, Aldrich RW (1988) Voltage-dependent K+ currents and underlying single K+ channels in pheochromocytoma cells. J Gen Physiol 91:73–106Google Scholar
  76. Howard BD, Gundersen CB (1980) Effects and mechanisms of polypeptide neurotoxins that act presynaptically. Ann Rev Pharmacol Toxicol 20:307–336Google Scholar
  77. Hugues M, Duval D, Kitabgi P, Lazdunski M, Vincent JP (1982a) Preparation of a pure monoiodo derivative of the bee venom neurotoxin apamin and its binding properties to rat brain synaptosomes. J. Biol Chem 257:2762–2769Google Scholar
  78. Hugues M, Duval D, Schmid H, Kitabgi P, Lazdunski M, Vincent JP (1982b) Specific binding and pharmacological interactions of apamin, the neurotoxin from bee venom, with guinea-pig colon. Life Sci 31:437–443Google Scholar
  79. Hugues M, Romey G, Duval D, Vincent JP, Lazdunski M (1982c) Apamin as a selective blocker of the calcium-dependent potassium channel in neuroblastoma cells: Voltage-clamp and biochemical characterization of the toxin receptor. Proc Natl Acad Sci USA 79:1308–1312Google Scholar
  80. Hugues M, Schmid H, Lazdunski M (1982d) Identification of a protein component of the Ca2+-dependent K+ channel by affinity labelling with apamin. Biochem Biophys Res Commun 107:1577–1582Google Scholar
  81. Hugues M, Schmid H, Romey G, Duval D, Frelin C, Lazdunski M (1982e) The Ca2+-dependent slow K+ conductance in cultured rat muscle cells: characterization with apamin. EMBO J 1:1039–1042Google Scholar
  82. Janicki PK, Horvath E, Seibold G, Habermann E (1984) Quantitative autoradiography of [125I]apamin binding sites in the central nervous system. Biomed Biochim Acta 43:1371–1375Google Scholar
  83. Jenkinson DH, Haylett DG, Cook NS (1983) Calcium-activated potassium channels in liver cells. Cell Calcium 4:429–437Google Scholar
  84. Jonas P, Bräu ME, Hermsteiner M, Vogel W (1989) Single-channel recording in myelinated nerve fibres reveals one type of Na channel but different K channels. Proc Natl Acad Sci USA 86:17238–17243Google Scholar
  85. Joubert FJ, Taljaard N (1980) The amino acid sequences of two proteinase inhibitor homologues from Dendroaspis angusticeps venom. Hoppe-Seylers Z Physiol Chem 361:661–674Google Scholar
  86. Karlsson E (1979) Chemistry of protein toxins in snake venoms. In: Lee CA (ed) Snake venoms, chap 5. Springer, Berlin Heidelberg New York, pp 159–212 (Handbook of experimental pharmacology, vol 52)Google Scholar
  87. Kawai T, Watanabe M (1986) Blockade of Ca-activated K conductance by apamin in rat sympathetic neurones. Br J Pharmacol 87:225–232Google Scholar
  88. Kitabgi P, Vincent J-P (1981) Neurotensin is a potent inhibitor of guinea-pig colon contractile activity. Eur J Pharmacol 74:311–318Google Scholar
  89. Koppenhöfer E, Schmidt H (1968) Die Wirkung von Skorpiongift auf die Ionenströme des Ranvierschen Schnürrings. I. Die Permeabilitäten PNa und PK. Pflügers Arch 303:133–149Google Scholar
  90. Lancaster B, Nicoll RA (1987) Properties of two calcium-activated hyperpolarizations in rat hippocampal neurones. J Physiol (Lond) 389:187–203Google Scholar
  91. Lebrun P, Atwater I, Claret M, Malaisse WJ, Herchuelz A (1983) Resistance to apamin of the Ca2+-activated K+ permeability in pancreatic B-cells. FEBS Lett 161:40–44Google Scholar
  92. Lewis RS, Cahalan MD (1988) Subset-specific expression of potassium channels in developing murine T lymphocytes. Science 239:771–775Google Scholar
  93. Maas AJJ, Den Hertog A (1979) The effect of apamin on the smooth muscle cells of the guinea-pig taenia coli. Eur J Pharmacol 58:151–156Google Scholar
  94. Maas AJJ, Den Hertog A, Ras R, Van den Akker J (1980) The action of apamin on guinea-pig taenia caeci. Eur J Pharmacol 67:265–274Google Scholar
  95. MacKinnon R, Miller C (1988) Mechanism of charybdotoxin block of the high-conductance, Ca2+-activated K+ channel. J Gen Physiol 91:335–349Google Scholar
  96. MacKinnon R, Reinhart PH, White MM (1988) Charybdotoxin block of Saker K+ channels suggests that different types of K+ channels share common structural features. Neuron 1:997–1001Google Scholar
  97. Mallart A (1985) Electric current flow inside perineural sheaths of mouse motor nerves. J Physiol (Lond) 368:565–575Google Scholar
  98. Marqueze B, Seagar M, Couraud F (1987) Photoaffinity labeling of the K+ channel-associated apamin-binding molecule in smooth muscle, liver and heart membranes. Eur J Biochem 169:295–298Google Scholar
  99. Mehraban F, Breeze AL, Dolly JO (1984) Identification by cross-linking of a neuronal acceptor protein for dendrotoxin, a convulsant polypeptide. FEBS Lett 174:116–122Google Scholar
  100. Mehraban F, Black AR, Breeze AL, Green DG, Dolly JO (1985) A functional membranous acceptor for dendrotoxin in rat brain: solubilization of the binding component. Biochem Soc Trans 13:507–508Google Scholar
  101. Miller C (1988) Competition for block of a Ca2+-activated K+ channel by charybdotoxin and tetraethylammonium. Neuron 1:1003–1006Google Scholar
  102. Miller C, Moczydlowski E, Latorre R, Philipps M (1985) Charybdotoxin, a protein inhibitor of single Ca2+-activated K+ channels from mammalian skeletal muscle. Nature 313:316–318Google Scholar
  103. Moczydlowski E, Lucchesi K, Ravindran A (1988) An emerging pharmacology of peptide toxins targeted against potassium channels. J Membrane Biol 105:95–111Google Scholar
  104. Mourre C, Schmid-Antomarchi H, Hugues M, Lazdunski M (1984) Autoradiographic localization of apamin-sensitive Ca2+-dependent K+ channels in rat brain. Eur J Pharmacol 100:135–136Google Scholar
  105. Mourre C, Hugues M, Lazdunski M (1986) Quantitative autoradiographic mapping in rat brain of the receptor of apamin, a polypeptide toxin specific for one class of Ca2+-dependent K+ channels. Brain Res 382:239–249Google Scholar
  106. Mourre C, Cervera P, Lazdunski M (1987) Autoradiographic analysis in rat brain of the postnatal ontogeny of voltage-dependent Na+ channels, Ca2+-dependent K+ channels and slow Ca2+ channels identified as receptors for tetrodotoxin, apamin and (−)desmethoxyverapamil. Brain Res 417:21–32Google Scholar
  107. Mourre C, Bidard J-N, Lazdunski M (1988) High affinity receptors for the bee venom MCD peptide. Quantitative autoradiographic localization at different stages of brain development and relationship with MCD neurotoxicity. Brain Res 446:106–112Google Scholar
  108. Nanberg E, Connolly E, Nedergaard J (1985) Presence of Ca2+-dependent K+ channel in brown adipocytes. Possible role in maintenance of α1-adrenergic stimulation. Biochim Biophys Acta 844:42–49Google Scholar
  109. Naraghashi T, Shapiro BI, Deguchi T, Scuka M, Wang CM (1972) Effects of scorpion venom on squid axon membranes. Am J Physiol 222:850–857Google Scholar
  110. Oberg SG, Kelly RB (1976) Saturable binding to cell membranes of the presynaptic neurotoxin, β-bungarotoxin. Biochim Biophys Acta 433:662–673Google Scholar
  111. Olivera BM, Gray WR, Zeikus R, McIntosh JM, Varga J, Rivier J, de Santos V, Cruz LJ (1985) Peptide neurotoxins from fish-hunting cone snails. Science 230:1338–1343Google Scholar
  112. Othman IB, Spokes JW, Dolly JO (1982) Preparation of neurotoxic [3H]-β-bungarotoxin: demonstration of saturable binding to brain synapses and its inhibition by toxin I. Eur J Biochem 128:267–276Google Scholar
  113. Othman IB, Wilkin GP, Dolly JO (1983) Synaptic binding sites in brain for 3H-β-bungarotoxin — a specific probe that perturbs transmitter release. Neurochem Int 5:487–496Google Scholar
  114. Pappone PA, Cahalan MD (1987) Pandinus imperator scorpion venom blocks voltage-gated potassium channels in nerve fibers. J Neurosci 7:3300–3305Google Scholar
  115. Pappone PA, Lucero MT (1988) Pandinus imperator scorpion venom blocks voltage-gated potassium channels in GH3 cells. J Gen Physiol 91:817–833Google Scholar
  116. Pelchen-Matthews A, Dolly JO (1988) Distribution of acceptors for β-bungarotoxin in the central nervous system of the rat. Brain Res 441:127–138Google Scholar
  117. Pennefather P, Lancaster B, Adams PR, Nicoll RA (1985) Two distinct Ca-dependent K currents in bullfrog sympathetic ganglion cells. Proc Natl Acad Sci USA 82:3040–3044Google Scholar
  118. Penner R, Dreyer F (1986) Two different presynaptic calcium currents in mouse motor nerve terminals. Pflügers Arch 406:190–197Google Scholar
  119. Penner R, Petersen M, Pierau Fr-K, Dreyer F (1986) Dendrotoxin: a selective blocker of a non-inactivating potassium current in guinea-pig dorsal root ganglion neurones. Pflügers Arch 407:365–369Google Scholar
  120. Petersen M, Penner R, Pierau Fr-K, Dreyer F (1986) β-Bungarotoxin inhibits a non-inactivating potassium current in guinea pig dorsal root ganglion neurones. Neurosci Lett 68:141–145Google Scholar
  121. Possani LD, Martin BM, Svendsen IB (1982) The primary structure of noxiustoxin: a K+ channel blocking peptide, purified from the venom of the scorpion Centruroides Noxius Hoffmann. Carlsberg Res Commun 47:285–289Google Scholar
  122. Rehm H, Betz H (1982) Binding of β-bungarotoxin to synaptic membrane fractions of chick brain. J Biol Chem 257:10015–10022Google Scholar
  123. Rehm H, Betz H (1983) Identification by crosslinking of a β-bungarotoxin binding polypeptide in chick brain menbranes. EMBO J:1119–1122Google Scholar
  124. Rehm H, Betz H (1984) Solubilization and characterization of the β-bungarotoxin-binding protein of chick brain membranes. J Biol Chem 259:6865–6869Google Scholar
  125. Rehm H, Lazdunski M (1988a) Purification and subunit structure of a putative K+-channel protein identified by its binding properties for dendrotoxin I. Proc Natl Acad Sci USA 85:4919–4923Google Scholar
  126. Rehm H, Lazdunski M (1988b) Existence of different populations of the dendrotoxin I binding protein associated with neuronal K+ channels. Biochem Biophys Res Commun 153:231–240Google Scholar
  127. Rehm H, Bidard J-N, Schweitz H, Lazdunski M (1988) The receptor site for the bee venom mast cell degranulating peptide. Affinity labeling and evidence for a common molecular target for mast cell degranulating peptide and dendrotoxin I, a snake toxin active on K+ channels. Biochemistry 27:1827–1832Google Scholar
  128. Renaud J-F, Desnuelle C, Schmid-Antomarchi H, Hugues M, Serratrice G, Lazdunski M (1986) Expression of apamin receptor in muscles of patients with myotonic muscular dystrophy. Nature 319:678–680Google Scholar
  129. Ritchie AK (1987) Two distinct calcium-activated potassium currents in a rat anterior pituitary cell line. J Physiol (Lond) 385:591–609Google Scholar
  130. Rogawski MA (1985) The A-current: how ubiquitous a feature of excitable cells is it? Trends Neurosci 83:214–219Google Scholar
  131. Romey G, Lazdunski M (1984) The coexistence in rat muscle cells of two distinct classes of Ca2+-dependent K+ channels with different pharmacological properties and different physiological functions. Biochem Biophys Res Commun 118:669–674Google Scholar
  132. Romey G, Chicheportiche R, Lazdunski M (1975) Scorpion neurotoxin, a presynaptic toxin which affects both Na+ and K+ channels in axons. Biochem Biophys Res Commun 64:115–121Google Scholar
  133. Romey G, Hugues M, Schmid-Antomarchi H, Lazdunski M (1984) Apamin: a specific toxin to study a class of Ca2+-dependent K+ channels. J Physiol (Paris) 79:259–264Google Scholar
  134. Rosario LM (1985) Differential effects of the K+ channel blockers apamin and quinine on glucose-induced electrical activity in pancreatic beta-cells from a strain of OB/OB (obese) mice. FEBS Lett 188:302–306Google Scholar
  135. Rowan EG, Harvey AL (1988) Potassium channel blocking actions of β-bungarotoxin and related toxins on mouse and frog motor nerve terminals. Br J Pharmacol 94:839–847Google Scholar
  136. Rudy B (1988) Diversity and ubiquity of K channels. Neuroscience 25:729–749Google Scholar
  137. Schauf CL (1987) Dendrotoxin blocks potassium channels and slows sodium inactivation in Myxicola giant axons. J Pharmacol Exp Ther 241:793–796Google Scholar
  138. Schmid-Antomarchi H, Hugues M, Norman R, Ellory C, Borsotto M, Lazdunski M (1984) Molecular properties of the apamin-binding component of the Ca2+-dependent K+ channel. Radiation-inactivation, affinity labelling and solubilization. Eur J Biochem 142:1–6Google Scholar
  139. Schmid-Antomarchi H, Renaud J-F, Romey G, Hugues M, Schmid A, Lazdunski M (1985) The all-or-none role of innervation in expression of apamin receptor and of apamin-sensitive Ca2+-activated K+ channel in mammalian skeletal muscle. Proc Natl Acad Sci USA 82:2188–2191Google Scholar
  140. Schmid-Antomarchi H, Hugues M, Lazdunski M (1986) Properties of the apamin-sensitive Ca2+-activated K+ channel in PC12 pheochromocytoma cells which hyperproduce the apamin receptor. J Biol Chem 261:8633–8637Google Scholar
  141. Schmidt RR, Betz H (1988) The β-bungarotoxin-binding protein from chick brain: binding sites for different neuronal K+ channel ligands co-fractionate upon partial purification. FEBS Lett 240:65–70Google Scholar
  142. Schmidt RR, Betz H, Rehm H (1988) Inhibition of β-bungarotoxin binding to brain membranes by mast cell degranulating peptide, toxin I and ethylene glycol bis (β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid. Biochemistry 27:963–967Google Scholar
  143. Schweitz H, Stansfeld CE, Bidard J-N, Fagni L, Maes P, Lazdunski M (1989) Charybdotoxin blocks dendrotoxin-sensitive voltage-activated K+ channels. FEBS Lett 250:519–522Google Scholar
  144. Seagar MJ, Granier C, Couraud F (1984) Interactions of the neurotoxin apamin with a Ca2+-activated K+ channel in primary neuronal cultures. J Biol Chem 259:1491–1495Google Scholar
  145. Seagar MJ, Labbé-Jullié C, Granier C, van Rietschoten J, Couraud F (1985) Photoaffinity labeling of components of the apamin-sensitive K+ channel in neuronal membranes. J Biol Chem 260:3895–3898Google Scholar
  146. Seagar MJ, Labbé-Jullié C, Granier C, Goll A, Glossmann H, van Rietschoten J, Couraud F (1986) Molecular structure of rat brain apamin receptor: differential photoaffinity labelling of putative K+ channel subunits and target size analysis. Biochemistry 25:4051–4057Google Scholar
  147. Seagar MJ, Deprez P, Martin-Moutot N, Couraud F (1987a) Detection and photoaffinity labeling of the Ca2+-activated K+ channel-associated apamin receptor in cultured astrocytes from rat brain. Brain Res 411:226–230Google Scholar
  148. Seagar MJ, Marqueze B, Couraud F (1987b) Solubilization of the apamin receptor associated with a calcium-activated potassium channel from rat brain. J Neurosci 7:565–570Google Scholar
  149. Shuba MF, Vladimirova IA (1980) Effect of apamin on the electrical responses of smooth muscle to adenosine 5′-triphosphate and to non-adrenergic, non-cholinergic nerve stimulation. Neuroscience 5:853–859Google Scholar
  150. Silveira R, Barbeito L, Dajas F (1988) Behavioral and neurochemical effects of intraperitoneally injected dendrotoxin. Toxicon 26:287–292Google Scholar
  151. Sitges M, Possani LD, Bayon A (1986) Noxiustoxin, a shortchain toxin from the Mexican scorpion Centruroides noxius, induces transmitter release by blocking K+ permeability. J Neurosci 6:1570–1574Google Scholar
  152. Smith C, Phillips M, Miller C (1986) Purification of charybdotoxin, a specific inhibitor of the high-conductance Ca2+-activated K+ channel. J Biol Chem 261:14607–14613Google Scholar
  153. Solc CK, Zagotta WN, Aldrich RW (1987) Single-channel and genetic analysis reveal two distinct A-type potassium channels in Drosophila. Science 236:1094–1098Google Scholar
  154. Stanfield PR (1983) Tetraethylammonium ions and the potassium permeability of excitable cells. Rev Physiol Biochem Pharmacol 97:1–67Google Scholar
  155. Stansfeld CE, Feltz A (1988) Dendrotoxin-sensitive K+ channels in dorsal root ganglion cells. Neurosci Lett 93:49–55Google Scholar
  156. Stansfeld CE, Marsh SJ, Halliwell JV, Brown DA (1986) 4-Aminopyridine and dendrotoxin induce repetitive firing in rat visceral sensory neurones by blocking a slowly inactivating outward current. Neurosci Lett 64:299–304Google Scholar
  157. Stansfeld CE, Marsh SJ, Parcej DN, Dolly JO, Brown DA (1987) Mast cell degranulating peptide and dendrotoxin selectively inhibit a fast-activating potassium current and bind to common neuronal proteins. Neurosci 23:893–902Google Scholar
  158. Storm JF (1987) Action potential repolarization and a fast after-hyperpolarization in rat hippocampal pyramidal cells. J Physiol (Lond) 385:733–759Google Scholar
  159. Strydom DJ (1973) Protease inhibitors as snake venom toxins. Nature (New Biol) 243:88–89Google Scholar
  160. Stühmer W, Stocker M, Sakmann B, Seeburg P, Baumann A, Grupe A, Pongs O (1988) Potassium channels expressed from rat bain cDNA have delayed rectifier properties. FEBS Lett 242:199–206Google Scholar
  161. Szente MB, Baranyi A, Woody CD (1988) Intracellular injection of apamin reduces a slow potassium current mediating afterhyperpolarizations and IPSPs in neocortical neurons of cats. Brain Res 461:64–74Google Scholar
  162. Tabti N, Bourret C, Mallart A (1989) Three potassium currents in mouse motor nerve terminals. Pflügers Arch 413:395–400Google Scholar
  163. Tanaka K, Minota S, Kuba K, Koyano K, Abe T (1986) Differential effects of apamin on Ca2+-dependent K+ currents in bullfrog sympathetic ganglion cells. Neurosci Lett 69:233–238Google Scholar
  164. Tas PWL, Kress HG, Koschel K (1988) Presence of a charybodtoxin sensitive Ca2+-activated K+ channel in rat glioma C6 cells. Neurosci Lett 94:279–284Google Scholar
  165. Taylor JW, Bidard J-N, Lazdunski M (1984) The characterization of high-affinity binding sites in rat brain for the mast cell-degranulating peptide from the bee venom using the purified monoiodinated peptide. J Biol Chem 259:13957–13967Google Scholar
  166. Timpe LC, Schwarz TL, Tempel BL, Papazian DM, Jan YN, Jan LY (1988) Expression of functional potassium channels from Shaker cDNA in Xenopus oocytes. Nature 331:143–145Google Scholar
  167. Traoré, Cognard C, Potreau D, Raymond G (1986) The apamin-sensitive potassium current in frog skeletal muscle: its dependence on the extracellular calcium and sensitivity to calcium channel blockers. Pflügers Arch 407:199–203Google Scholar
  168. Tzeng M-C, Hseu MJ, Yang JH, Guillory RJ (1986) Specific binding of three neurotoxins with phospholipase A2 activity to synaptosomal membrane preparations from the guinea pig brain. J Protein Chem 5:221–228Google Scholar
  169. Valdivia HH, Smith JS, Martin BM, Coronado R, Possani LD (1988) Charybdotoxin and noxiustoxin, two homologous peptide inhibitors of the K+(Ca2+) channel. FEBS Lett 226:280–284Google Scholar
  170. Velluti JC, Caputi A, Macadar O (1987) Limbic epilepsy induced in the rat by dendrotoxin, a polypeptide isolated from the green mamba (Dendroaspis angusticeps) venom. Toxicon 25:649–657Google Scholar
  171. Vladimirova AI, Shuba MF (1978) Effect of strychnine, hydrastine and apamin on synaptic transmission in smooth muscle cells. Neurophysiology 10:213–217Google Scholar
  172. Weir SW, Weston AH (1986) Effect of apamin on responses to BRL 34915, nicorandil and other relaxants in the guinea-pig taenia caeci. Br J Pharmacol 88:113–120Google Scholar
  173. Weller U, Bernhardt U, Siemen D, Dreyer F, Vogel W, Habermann E (1985) Electrophysiological and neurobiochemical evidence for the blockade of a potassium channel by dendrotoxin. Naunyn-Schmiedeberg's Arch Pharmacol 330:77–83Google Scholar
  174. Wolff D, Cecchi X, Spalvins A, Canessa M (1988) Charybdotoxin blocks with high affinity the Ca-activated K+ channel of Hb A and Hb S red cells: individual differences in the number of channels. J Membrane Biol 106:243–252Google Scholar
  175. Wu K, Carlin R, Sachs L, Siekevitz P (1985) Existence of a Ca2+-dependent K+ channel in synaptic membrane and postsynaptic density fractions isolated from canine cerebral cortex and cerebellum, as determined by apamin binding. Brain Res 360:183–194Google Scholar
  176. Zhang L, Krnjevic K (1987) Apamin depresses selectively the after-hyperpolarization of cat spinal mononeurons. Neurosci Lett 74:58–62Google Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Florian Dreyer
    • 1
  1. 1.Rudolf-Buchheim-Institut für PharmakologieJustus-Liebig UniversitätGießenFRG

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