Marker guided registration of electromagnetic dipole data with tomographic images

  • P A van den Elsen
  • M A Viergever
3. Multi-Modal Registration
Part of the Lecture Notes in Computer Science book series (LNCS, volume 511)


Anatomical interpretation of EEG and MEG derived source estimations is difficult, and their correspondence with pathology as revealed by medical images is hard to assess. In this study a method is presented to register electromagnetic source data with tomographic image data of the same patient, thus facilitating the interpretation of the dipole characteristics with respect to the patient's anatomy (MRI, CT) or metabolism (SPECT). The method utilizes external triangular markers that are easy to apply to the skin and indicate reference points with subslice accuracy, even if these are located slightly outside the scanned volume. In this way accurate matching is ensured not only in high resolution images but also in standard CT and MR imaging protocols employing thick slices and/or large interslice gaps. While a similar triangular marker can be used for SPECT imaging, point-like radioactive markers have been considered as well because of their simplicity. At present no final conclusions can be drawn about the optimal design of the SPECT marker. The clinical potential of dipole source modelling in epilepsy and other neurological applications has not yet been established, mainly because the accuracy of the source estimations is still uncertain. The registration method proposed in this paper is much more accurate than the present-day source estimations, and hence will keep its value when improved dipole models are developed.


CT EEG Epilepsy MEG MRI SPECT Volume Visualization 


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  1. Barth DS, Sutherling W, Engle Jr J and Beatty J (1984). Neuromagnetic evidence of spatially distributed sources underlying epileptiform spikes in the human brain. Science 223:293–296.Google Scholar
  2. Barth DS, Baumgartner C and Sutherling WW (1989). Neuromagnetic field modeling of multiple brain regions producing interictal spikes in human epilepsy. Electroenceph. Clin. Neurophysiol. 73:389–402.Google Scholar
  3. Buchsbaum MS, Hazlett E, Sicotte N, Ball R and Johnson S (1986). Geometric and scaling issues in topographic electroencephalography. In: Topographical mapping of brain electrical activity. Duffy FH (Ed.), Butterworth Publishers, Stoneham, pp. 325–337.Google Scholar
  4. Chang H (1990). Geometric image transformation to compensate for distortions in magnetic resonance imaging. PhD Thesis, Vanderbilt University, Nashville, Tennessee.Google Scholar
  5. De Munck JC (1989). A mathematical and physical interpretation of the electromagnetic field of the brain. PhD Thesis, University of Amsterdam, Amsterdam.Google Scholar
  6. De Munck JC (1990). The estimation of time varying dipoles on the basis of evoked potentials. Electroenceph. Clin. Neurophysiol. 77:156–160.Google Scholar
  7. Frank E (1952). Electric potential produced by two point current sources in a homogeneous conducting sphere. J. Appl. Phys. 23:1225–1227.Google Scholar
  8. George JS, Jackson PS, Ranken DM and Flynn ER (1989). Three-dimensional volumetric reconstruction for neuromagnetic source localization. In: Advances in biomagnetism. Williamson SJ, Hoke M, Stroink G and Kotani M (eds.), Plenum Press, New York, pp. 737–740.Google Scholar
  9. Gevins A, Brickett P, Costales B, Le J and Reutter B (1990). Beyond topographic mapping: towards functional-anatomical imaging with 124-channel EEGs and 3-D MRIs. Brain Topography 3:53–64.Google Scholar
  10. Levoy M (1988) Display of surfaces from volume data. IEEE Computer Graphics and Applications 8–3:29–37.Google Scholar
  11. Meijs JWH, Bosch FGC, Peters MJ and Lopes da Silva FH (1987). On the magnetic field distribution generated by a dipolar current source situated in a realistically shaped compartment model of the head. Electroenceph. Clin. Neurophysiol. 66:286–298.Google Scholar
  12. Orrison WW, Davis LE, Sullivan GW, Mettler Jr FA and Flynn ER 1990). Anatomical localization of cerebral cortical function by magnetoencephalography combined with MR Imaging and CT. AJNR 11:713–716.Google Scholar
  13. Pantev C, Hoke M, Lehnertz K, Lütkenhöner B, Fahrendorf G and Stöber U (1990). Identification of sources of brain neuronal activity with high spatiotemporal resolution through combination of neuromagnetic source localization (NMSL) and magnetic resonance imaging (MRI). Electroenceph. Clin. Neurophysiol. 75:173–184.Google Scholar
  14. Salustri C and Chapman RM (1989). A simple method for 3-dimensional localization of epileptic activity recorded by simultaneous EEG and MEG. Electroenceph. Clin. Neurophysiol. 73:473–478.Google Scholar
  15. Samson Y, Hantrage P, Baron JC, Soussaline F, Comar D and Maziëre M (1985). A benzodiazepine antagonist studied in human brain in vivo by positron tomography. Europ. Journal of Pharmacology 110:247–251.Google Scholar
  16. Ueno S and Iramina K (1990). Modeling and source localization of MEG activities. Brain Topography 3:151–165.Google Scholar
  17. Van der Meij W, Van Huffelen AC and Wieneke GH (1990). EEG mapping and dipole modelling of rolandic spikes. Neurophysiol. Clin. 20 S, 2s (Abstract).Google Scholar
  18. Van Huffelen AC, Van Isselt JW, Van Veelen CWM, Van Rijk PP, Van Bentum AME, Dive D, Maquet P, Franck G, Velis DN, Van Emde Boas W and Debets RMChr (1990). Identification of the side of the epileptic focus with 123I-Iomazenil SPECT. Acta Neurochirurgica, Suppl. 50:95–99.Google Scholar
  19. Weinberg H, Wong PKH, Crisp D, Johnson B and Cheyne D (1990). Use of multiple dipole analysis for the classification of benign rolandic epilepsy. Brain Topography 3:183–190.Google Scholar
  20. Witwer JG, Trezek GJ and Jewett DL (1972). The effect of media inhomogeneities upon intracranial electrical fields. IEEE Trans. on Biomed. Engng. 19:352–362.Google Scholar
  21. Wong PKH (1989). Stability of source estimates in rolandic spikes. Brain Topography 2:31–36.Google Scholar
  22. Yamamoto T, Williamson SJ, Kaufman L, Nicholson C and Llinás R (1988). Magnetic localization of neuronal activity in the human brain. Proc. Natl. Acad. Sci. USA 85:8732–8736.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • P A van den Elsen
    • 1
  • M A Viergever
    • 1
  1. 1.Computer Vision Research GroupUniversity Hospital UtrechtThe Netherlands

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