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Structure and function of cGMP-dependent protein kinases

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References

  • Aitken A; Bilham T; Cohen P; Aswad D; Greengard P (1981) A specific substrate from rabbit cerebellum for guanosine-3′:5′-monophosphate-dependent protein kinase. III. Amino acid sequences at the two phosphorylation sites. J Biol Chem 256:3501–3506

    Google Scholar 

  • Aitken A, Hemmings BA, Hofmann F (1984) Identification of the residues on cyclic GMP-dependent protein kinase that are autophosphorylated in the presence of cyclic AMP and cyclic GMP. Biochim Biophys Acta 790:219–225

    Google Scholar 

  • Alioua A, Tanaka Y, Meera P, Wallner M, Hofmann F, Ruth P, Toro L (1998) Biochemical evidence for direct phosphorylation of the maxiK channel α-subunit (hslo) by cGMP-dependent protein kinase (PKG). Biophys J 74:A211

    Google Scholar 

  • Ally S, Tortora G, Clair T, Grieco D, Merlo G, Katsaros D, Ogreid D, Doskeland SO, Jahnsen T, Cho-Chung-YS (1988) Selective modulation of protein kinase isozymes by the site-selective analog 8-chloroadenosine 3′,5′-cyclic monophosphate provides a biological means for control of-human colon cancer cell growth. Proc Nat Am Soc USA 85:6319–6322

    Google Scholar 

  • Arancio O, Kandel ER, Hawkins RD (1995) Activity-dependent long-term enhancement of transmitter release by presynaptic 3′,5′-cyclic GMP in cultured hippocampal neurons. Nature 376:74–80

    Google Scholar 

  • Ariano MA, Lewicki JA, Brandwein HJ, Murad F (1982) Immunohistochemical localization of guanylate cyclase within neurons of rat brain. Proc Natl Acad Sci USA 79:1316–1320

    Google Scholar 

  • Atkinson RA, Saudek V, Huggins JP, Pelton JT (1991) 1H NMR and circular dichroism studies of the N-terminal domain of cyclic GMP dependent protein kinase: a leucine/isoleucine zipper. Biochemistry 30:9387–9395

    Google Scholar 

  • Biel M, Zong X, Ludwig A, Sautter A, Hofmann F (1998) Structure and function of cyclic nucleotide-gated channels. Rev Physiol Biochem Pharmacol Chapter 5

    Google Scholar 

  • Bliss TVP, Collinridge GL (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361:31–39

    Google Scholar 

  • Bolshakov VV, Siegelbaum SA (1995) Regulation of hippocampal transmitter release during development and long-term potentiation. Science 269:1730–1734

    Google Scholar 

  • Bossemeyer D, Engh RA, Kinzel V, Ponstingl H, Huber R (1993) Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5–24). EMBO J 12:849–859

    Google Scholar 

  • Bredt DS, Hwang PM, Snyder SH (1990) Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 347:768–770

    Google Scholar 

  • Burns AJ, Lomax AEJ, Torihashi S, Sanders KM, Ward SM (1996) Interstitial cells of Cajal mediate inhibitory neurotransmission. Proc Natl Acad Sci USA 93:12008–12013

    Google Scholar 

  • Butt E, Abel K, Krieger M, Palm D, Hoppe V, Hoppe J, Walter U (1994) cAMP-and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets. J Biol Chem 269:14509–14517

    Google Scholar 

  • Butt E, Pöhler D, Genieser HG, Huggins JP, Bucher B (1995) Inhibition of cyclic GMP-dependent protein kinase-mediated effects by (Rp)-8-bromo-PET-cyclic GMPS. Br J Pharmacol 116:3110–3116

    Google Scholar 

  • Calderone A, Thaik CM, Takahashi N, Chang DLF, Colucci WS (1998) Nitric oxide, atrial natriuretic peptide, and cyclic GMP inhibit the growth-promoting effects of norepinephrine in cardiac myocytes and fibroblasts. J Clin Invest 101:812–818

    Google Scholar 

  • Casey PJ (1995) Protein lipidation in cell signaling. Science 268:221–225

    Google Scholar 

  • Chao DS, Silvagno F, Xia H, Cornwell TL, Lincoln TM, Bredt DS (1997) Nitric oxide synthase and cyclic GMP-dependent protein kinase concentrated at the neuromuscular endplate. Neuroscience 76:665–672

    Google Scholar 

  • Charles IG, Palmer RM, Hickery MS, Bayliss MT, Chubb AP, Hall VS, Moss DW, Moncada S (1993) Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte. Proc Natl Acad Sci USA 90:11419–11423

    Google Scholar 

  • Chestukhin A, Litovchick L, Schourov D, Cox S, Taylor SS, Shaltiel S (1996) Functional malleability of the carboxyl-terminal tail in protein kinase A. J Biol Chem 271:10175–10182

    Google Scholar 

  • Colbran JL, Francis SH, Leach AB, Thomas MK, Jiang H, McAllister LM, Corbin JD (1992) A phenylalanine in peptide substrates provides for selectivity between cGMP-and cAMP-dependent protein kinases. J Biol Chem 267:9589–9594

    Google Scholar 

  • Corbin JD, Ogreid D, Miller JP, Suva RH, Jastorff B, Doskeland SO (1986) Studies of cGMP analog specificity and function of the two intrasubunit binding sites of cGMP-dependent protein kinase. J Biol Chem 261:1208–121

    Google Scholar 

  • Cornwell TL, Lincoln TM (1989) Regulation of intracellular Ca2+ levels in cultured vascular smooth muscle cells. J Biol Chem 264:1146–1155

    Google Scholar 

  • Currie MG, Fok KF, Kato J, Moore RJ, Hamra FK, Duffin KL, Smith CE (1992) Guanylin: an endogenous activator of intestinal guanylate cyclase. Proc Natl Acad Sci USA 89:947–951

    Google Scholar 

  • De Jonge HR (1981) Cyclic GMP-dependent protein kinase in intestinal brush borders. Adv Cyclic Nucleotide Res 14:315–333

    Google Scholar 

  • Desai KM, Zembowicz A, Sessa WC, Vane JR (1991) Nitroxergic nerves mediate vagally induced relaxation in the isolated stomach of the guinea pig. Proc Natl Acad Sci USA 88:11490–11494

    Google Scholar 

  • Dey NB, Boerth NJ, Murphy-Ullrich JE, Chang PL, Prince CW, Lincoln TM (1998) Cyclic GMP-dependent protein kinase inhibits osteopontin and thrombospondin production in rat aortic smooth muscle cells. Circ Res 82:139–146

    Google Scholar 

  • Diwan AH, Thompson WJ, Lee AK, Strada SJ (1994) Cyclic GMP-dependent protein kinase activity in rat pulmonary microvascular endothelial cells. Biochem Biophys Res Commun 202:728–735

    Google Scholar 

  • Dostmann WRG (1995) (Rp)-cAMPS inhibits the cAMP-dependent protein kinase by blocking the cAMP-induced conformational transition. FEBS Lett 375:231–234

    Google Scholar 

  • Dostmann WRG, Taylor SS (1991) Identifying the molecular switches that determine whether (Rp)-cAMPS functions as an antagonist or an agonist in the activation of cAMP-dependent protein kinase. Biochemistry 30:8710–8716.

    Google Scholar 

  • Dostmann WRG, Taylor SS, Genieser HG, Jastorff B, Doskeland SO, Ogreid D (1989) Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3′,5′-cyclic phosphorothioates. J Biol Chem 265:10484–10491

    Google Scholar 

  • Draijer R, Vaandrager AB, Nolte C, De Jonge HR, Walter U, van Hinsbergh VW (1995) Expression of cGMP-dependent protein kinase I and phosphorylation of its substrate, vasodilator-stimulated phosphoprotein, in human endothelial cells of different origin. Circ Res 77:897–905

    Google Scholar 

  • Eigenthaler M, Ullrich H, Geiger J, Horstrup K, Honig-Liedl P, Wiebecke D, Wlater U (1993) Defective nitrovasodilator-stimulated protein phosphorylation and calcium regulation in cGMP-dependent protein kinase-deficient human platelts of chronic myelocytic leukemia. J Biol Chem 268:13526–13531

    Google Scholar 

  • El-Daher SS, Eigenthaler M, Walter U, Furuichi T, Miyawaki A, Mikoshiba K, Kakkar V, Authi K (1996) Distribution and activation of cAMP-and cGMP-dependent protein kinases in highly purified human platelet plasma and intracellular membranes. Thromb. Haemostasis 76:1063–1071

    Google Scholar 

  • El-Husseini AE, Bladen C, Vincent SR (1995) Molecular characterization of a type II cyclic GMP-dependent protein kinase expressed in the rat brain. J Neurochem 64:2814–2817

    Google Scholar 

  • Eliasson MJL, Blackshaw S, Schell MJ, Snyder SH (1997) Neuronal nitric oxide synthase alternatively spliced forms: prominent functional localizations in the brain. Proc Natl Acad Sci USA 94:3396–3401

    Google Scholar 

  • Engh RA, Girod A, Kinzel V, Huber R, Bossemeyer D (1996) Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity. J Biol Chem 271:26157–26164

    Google Scholar 

  • Feil R, Kellermann J, Hofmann F (1995) Functional cGMP-dependent protein kinase is phosphorylated in its catalytic domain at threonine-516. Biochemistry 34:13152–13158

    Google Scholar 

  • Felbel J, Trockur B, Ecker T, Landgraf W, Hofmann F (1988) Regulation of cytosolic calcium by cAMP and cGMP in freshly isolated smooth muscle cells from bovine trachea. J Biol Chem 263:16764–16771

    Google Scholar 

  • Field M, Rao MC, Chang EB (1989) Intestinal electrolyte transport and diarrheal disease (1) N Engl J Med 321:800–806

    Google Scholar 

  • Foster JL, Higgins GC, Jackson FR (1996) Biochemical properties and cellular localization of the Drosophila DG1 cGMP-dependent protein kinase. J Biol Chem 271:23322–23328

    Google Scholar 

  • Francis SH, Noblett BD, Todd BW, Wells JN, Corbin JD (1988) Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogues that preferentially activate purified cGMP-dependent protein kinase. Mol Pharmacol 34:506–517

    Google Scholar 

  • French PJ, Bijman J, Edixhoven M, Vaandrager AB, Scholte BJ, Lohmann SM, Nairn AC, de Jonge HR (1995) Isotype-specific activation of cystic fibrosis transmembrane conductance regulator-chloride channels by cGMP-dependent protein kinase II. J Biol Chem 270:26626–26631

    Google Scholar 

  • Fujii M, Ogata T, Takahashi E, Yamada K, Nakabayashi K, Oishi M, Ayusawa D (1995) Expression of the human cGMP-dependent protein kinase II gene is lost upon introduction of SV40 T antigen or immortalization in human cells. FEBS Lett 375:263–267

    Google Scholar 

  • Gambaryan S, Häusler C, Markert T, Pohler D, Jarchau T, Walter U, Haase W, Kurtz A, Lohmann SM (1996) Expression of type II cGMP-dependent protein kinase in rat kidney is regulated by dehydration and correlated with renin gene expression. J Clin Invest 98:662–670

    Google Scholar 

  • Gamm DM, Francis SH, Angelotti TP, Corbin JD, Uhler MD (1995) The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms. J Biol Chem 270:27380–27388

    Google Scholar 

  • Gardes J, Poux JM, Gonzalez MF, Alhenc-Gelas F, Menard J (1992) Decreased renin release and constant kallikrein secretion after injection of L-NAME in isolated perfused rat kidney. Life Sci 50:987–993

    Google Scholar 

  • Garg UC, Hassid A, (1989) Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest 83:1774–1777

    Google Scholar 

  • Geiger J, Nolte C, Butt E, Sage SO, Walter U (1992) Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets. Proc Natl Acad Sci USA 89:1031–1035

    Google Scholar 

  • Giannella RA (1981) Pathogenesis of acute bacterial diarrheal disorders. Ann Rev Med 32:341–357

    Google Scholar 

  • Gjertsen BT, Mellgren G, Otten A, Maronde E, Genieser HG, Jastorff B, Vintermyr OK, McKnight GS, Doskeland SO (1995) Novel (Rp)-cAMPS analogs as tools for inhibition of cAMP-kinase in cell culture. Basal cAMP-kinase activity modulates interleukin-1 beta action. J Biol Chem 270:20599–20607

    Google Scholar 

  • Glass DB (1983) Differential responses of cyclic GMP-dependent and cyclic AMP-dependent protein kinases to synthetic peptide inhibitors. Biochem J 213:159–164

    Google Scholar 

  • Glass DB, Cheng HC, Kemp BE, Walsh DA (1986) Differential and common recognition of the catalytic sites of the cGMP-dependent and cAMP-dependent protein kinases by inhibitory peptides derived from the heat-stable inhibitor protein. J Biol Chem 261:12166–12171

    Google Scholar 

  • Glass DB, Feller MJ, Levin LR, Walsh DA (1992) Structural basis for the low affinities of yeast cAMP-dependent and mammalian cGMP-dependent protein kinases for protein kinase inhibitor peptides. Biochemistry 31:1728–1734

    Google Scholar 

  • Glass DB, Krebs EG (1982) Phosphorylation by guanosine 3′:5′-monophosphate-dependent protein kinase of synthetic peptide analogs of a site phosphorylated in histone H2B. J Biol Chem 257:1196–200

    Google Scholar 

  • Grant PG, Mannarino AF, Colman RW (1990) Purification and characterization of a cyclic GMP-stimulated cyclic nucleotide phosphodiesterase from the cytosol of human platelets. Thromb Res 59:105–119

    Google Scholar 

  • Greenberg SG, He XR, Schnermann JB, Briggs JP (1995) Effect of nitric oxide on renin secretion. I. Studies in isolated juxtaglomerular granular cells. Am J Physiol 268:F948–F952

    Google Scholar 

  • Greenstein-Baynash A, Hosoda K, Giaid A, Richardson JA, Emoto N, Hammer RE, Yanagisawa M (1994) Interaction of enothelin-3 with endothelin-b receptor is essential for development of epidermal melanocytes and enteric neurons. Cell 79:1277–1285

    Google Scholar 

  • Grunberg B; Negrescu E; Siess. W (1995) Synergistic phosphorylation of platelet rap1B by SIN-1 and iloprost. Eur J Pharmacol 288:329–333

    Google Scholar 

  • Gudi T, Huvar I, Meinecke M, Lohmann SM, Boss GR, Pilz RB (1996) Regulation of gene expression by cGMP-dependent protein kinase. Transactivation of the c-fos promoter. J Biol Chem 271:4597–4600

    Google Scholar 

  • Gudi T, Lohmann SM, Pilz RB (1997) Regulation of gene expression by cyclic GMP-dependent protein kinase requires nuclear translocation of the kinase: identification of a nuclear localization signal. Mol Cell Biol 17:5244–5254

    Google Scholar 

  • Halbrügge M, Friedrich C, Eigenthaler M, Schanzenbacher P, Walter U (1990) Stoichiometric and reversible phophorylation of a 46-kD protein in human platelets in response to cGMP-and cAMP-elevating vasodilators. J Biol Chem 265:3088–3093

    Google Scholar 

  • Hanks SK, Hunter T (1995) The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J 9:576–596

    Google Scholar 

  • Hashimoto E; Takeda M; Nishizuka Y; Hamana K; Iwai K (1976) Studies on the sites in histones phosphorylated by adenosine 3′:5′-monophosphate-dependent and guanosine 3′:5′-monophosphate-dependent protein kinases. J Biol Chem 251:6287–6293

    Google Scholar 

  • He XR, Greenberg SG, Briggs JP, Schnermann JB (1995) Effect of nitric oxide on renin secretion. II. Studies in the perfused juxtaglomerular apparatus. Am J Physiol 268:F953–F959

    Google Scholar 

  • Heil WG, Landgraf W, Hofmann F (1987) A catalytically active fragment of cGMP-dependent protein kinase. Occupation of its cGMP-binding sites does not affect its phosphotransferase activity. Eur J Biochem 168:117–121

    Google Scholar 

  • Henrich WL, McAllister EA, Smith PB, Campbell WB (1988) Guanosine 3′,5′-cyclic monophosphate as a mediator of inhibition of renin release. Am J Physiol 255:F474–F478

    Google Scholar 

  • Herberg FW, Taylor SS, Dostmann WRG (1996) Active site mutations define the pathway for the cooperative activation of cAMP-dependent protein kinase. Biochemistry 35:2934–2942

    Google Scholar 

  • Hidaka H, Kobayashi R (1992) Pharmacology of protein kinase inhibitors. Annu Rev Pharmacol Toxicol 32:377–397

    Google Scholar 

  • Hofmann F, Dostmann W, Keilbach A, Landgraf W, Ruth P (1992) Structure and physiological role of cGMP-dependent protein kinase. Biochim Biophys Acta 1135:51–60

    Google Scholar 

  • Hofmann F, Gensheimer HP, Göbel, C (1985) cGMP-dependent protein kinase: Autophosphorylation changes the characteristics of binding site 1. Eur J Biochem 147:361–365

    Google Scholar 

  • Hofmann F, Ludwig A, Pfeifer A (1994) Cyclic GMP and the cotrol of airways smooth muscle tone. Airways Smooth Muscle: Biochemical Control of Contraction and Relaxation, D. Raeburn and M.A. Giembycz (eds); Birkhäuser Verlag Basel/Switzerland, 253–265

    Google Scholar 

  • Hofmann F, Sold G (1972) A protein kinase activity from rat cerebellum stimulated by guanosine-3′:5′-monophosphate. Biochem Biophys Res Commun 49:1100–1107

    Google Scholar 

  • Hosoda K, Hammer RE, Richardson JA, Greenstein-Baynash A, Cheung JC, Giaid A, Yanagisawa M (1994) Targeted and natural (Piebald-lethal) mutations of endothelin-b receptor gene produce megacolon associated with spotted coat color in mice. Cell 79:1267–1276

    Google Scholar 

  • Huang PL, Dawson TM, Bredt DS, Snyder S, Fishman M (1993) Targeted disruption of the neuronal nitric oxide synthase gene. Cell 75:1273–1286

    Google Scholar 

  • Huang PL, Huang Z, Mashimo H, Bloch KD, Moskowitz MA, Bevan JA, Fishman M (1995) Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature 377:239–242

    Google Scholar 

  • Huizinga JD, Thuneberg L, Klüppel M, Malysz J, Mikkelsen HB, Bernstein A (1995) W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity. Nature 373:347–349

    Google Scholar 

  • Ito M, Karachot L (1990) Messengers mediating long-term desensitization in cerebellar Purkinje cells. Neuroreport 1:129–132

    Google Scholar 

  • Ito M, Sakurai M, Tongroach P (1982) Climbing fibre induced depression of both mossy fibre responsiveness and glutamate sensitivity of cerebellar Purkinje cells. J Physiol Lond 324:113–134

    Google Scholar 

  • Jarchau T, Häusler C, Markert T, Pöhler D, Vandekerckhove J, De Jonge HR, Lohmann S, Walter U (1994) Cloning, expression, and in situ localization of rat intestinal cGMP-dependent protein kinase II. Proc Natl Acad Sci USA 91:9426–9430

    Google Scholar 

  • Jiang H, Colbran JL, Francis SH, Corbin JD (1992) Direct evidence for cross-activation of cGMP-dependent protein kinase by cAMP in pig coronary arteries. J Biol Chem 267:1015–1019

    Google Scholar 

  • Joyce NC, DeCamilli P, Lohmann SM, Walter U (1986) cGMP-dependent protein kinase is present in high concentrations in contractile cells of the kidney vasculature. J Cyclic Nucleotide Protein Phosphor Res 11:191–198

    Google Scholar 

  • Kalderon D, Rubin GM (1989) cGMP-dependent protein kinase genes in Drosophila. J Biol Chem 264:10738–10748

    Google Scholar 

  • Kase H, Iwahashi K, Nakanishi S, Matsuda Y, Yamada K, Takahashi M, Murakata C, Sato A, Kaneko M (1987) K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases. Biochem Biophys Res Commun 142:436–440

    Google Scholar 

  • Keilbach A, Ruth P, Hofmann F (1992) Detection of cGMP-dependent protein kinase isozymes by specific antibodies. Eur J Biochem 208:467–473

    Google Scholar 

  • Kemp BE, Pearson RB (1991) Intrasteric regulation of protein kinases and phosphatases. Biochim Biophys Acta 1094:67–76

    Google Scholar 

  • Kleppisch T, Pfeifer A, Klatt P, Ruth P, Montkowski A, Fässler R, Hofmann F (1998) Long-term potentiation in the hippocampal CA1 region of mice lacking the cGMP-dependent protein kinase is normal and susceptible to inhibition of NO synthase J Neurosci (in press)

    Google Scholar 

  • Knighton DR, Zheng JH, Ten Eyck LF, Ashford VA, Xuong NH, Taylor SS, Sowadski JM (1991) Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science 253:407–414

    Google Scholar 

  • Komalavilas P, Lincoln TM (1994) Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase. J Biol Chem 269:8701–8707

    Google Scholar 

  • Komalavilas P; Lincoln TM (1996) Phosphorylation of the inositol 1,4,5-trisphosphate receptor. Cyclic GMP-dependent protein kinase mediates cAMP and cGMP dependent phosphorylation in the intact rat aorta. J Biol Chem 271:21933–21938

    Google Scholar 

  • Kume H, Hall IP, Washabau RJ, Takagi K, Kotlikoff MI (1994) Beta-adrenergic agonists regulate KCa channels in airway smooth muscle by cAMP-dependent and-independent mechanisms. J Clin Invest 93:371–379

    Google Scholar 

  • Kume H, Tokuma H, Tomita T (1989) Regulation of Ca2+-dependent K+-channel activity in tracheal myocytes by phophorylation. Nature 341:152–154

    Google Scholar 

  • Kuo JF, Greengard P (1970) Isolation and partial purification of a protein kinase activated by guanosine 3′,5′-monophosphate. J Biol Chem 245:2493–2498

    Google Scholar 

  • Kurtz A, Della-Bruna R, Pfeilschifter J, Taugner R, Bauer C (1986) Atrial natriuretic peptide inhibits renin release from juxtaglomerular cells by a cGMP-mediated process. Proc Natl Acad Sci USA 83:4769–4773

    Google Scholar 

  • Landgraf W, Hofmann F (1989) The amino terminus regulates binding to and activation of cGMP-dependent protein kinase. Eur J Biochem 181:643–650

    Google Scholar 

  • Landgraf W, Hofmann F, Pelton JT, Huggins JP (1990) Effects of cyclic GMP on the secondary structure of cyclic GMP dependent protein kinase and analysis of the enzyme's amino-terminal domain by far-ultraviolet circular dichroism. Biochemistry 29:9921–9928

    Google Scholar 

  • Landgraf W, Hullin R, Göbel C, Hofmann F (1986) Phosphorylation of cGMP-dependent protein kinase increases the affinity for cyclic AMP. Eur J Biochem 154:113–117

    Google Scholar 

  • Lang D, Lewis MJ (1989) Endothelium-derived relaxing factor inhibits the formation of inositol trisphosphate by rabbit aorta. J Physiol 441:45–52

    Google Scholar 

  • Lev-Ram V, Jiang T, Wood J, Lawrence DS, Tsien RY (1997) Synergies and coincidence requirements between NO, cGMP, and Ca2+ in the induction of cerebellat long-term depression. Neuron 18:1025–1038

    Google Scholar 

  • Lev-Ram V, Makings LR, Keitz PF, Kao JPY, Tsien RY (1995) Long-term depression in cerebellar Purkinje neurons results from coincidence of nitric oxide and depolarization. Neuron 15:407–415

    Google Scholar 

  • Lincoln TM, Cornwell LT, Taylor AE (1990) cGMP-dependent protein kinase mediates the reduction of Ca2+ by cAMP in vascular smooth muscle cells. Am J Physiol 258:C399–C407

    Google Scholar 

  • Lincoln TM, Komalavilas P, Mac-Millan-Crow LA, Cornwell TL (1995) cGMP signaling through cAMP-and cGMP-dependent protein kinases. Adv Pharmacol 34:305–322

    Google Scholar 

  • Lincoln TM, Pryzwansky KB, Cornwell TL, Wyatt TA, MacMillan LA (1993). cyclic GMP-dependent protein kinase in smooth muscle and neutrophils. Adv Second Messenger Phosphoprotein Res 28:121–132

    Google Scholar 

  • Linden DJ, Dawson TM, Dawson VL (1995) An evaluation of the nitric oxide/cGMP/cGM-dependent protein kinase cascade in the induction of cerebellar long-term depression in culture. J Neurosci 15:5098–5105

    Google Scholar 

  • Lohmann SM, Walter U, Miller PE, Greengard P, De-Camilli P (1981) Immunohisto-chemical localization of cyclic GMP-dependent protein kinase in mammalian brain. Proc Natl Acad Sci USA 78:653–657

    Google Scholar 

  • MacMillan-Crow LA, Lincoln TM (1994) High-affinity binding and localization of the cyclic GMP-dependent protein kinase with the intermediate filament protein vimentin. Biochemistry 33:8035–8043

    Google Scholar 

  • MacMillan-Crow LA, Murphy Ullrich JE, Lincoln TM (1994) Identification and possible localization of cGMP-dependent protein kinase in bovine aortic endothelial cells. Biochem Biophys Res Commun 201:531–537

    Google Scholar 

  • Macphee CH, Reifsnyder DH, Moore TA, Lerea KM, Beavo JA (1988) Phosphorylation results in activation of a cAMP phosphodiesterase in human platelets. J Biol Chem 263:10353–10358

    Google Scholar 

  • Maeda H, Yamagata A, Nishikawa S, Yoshinaga K, Kobayashi S, Nishi K, Nishikawa S-I (1992) Requirement of c-kit for development of intestinal pacemaker system. Development 116:369–375

    Google Scholar 

  • Magrinat G, Mason SN, Shami PJ, Weinberg JB (1992) Nitric oxide modulation of human leukemia cell differentiation and gene expression. Blood 80:1880–1884

    Google Scholar 

  • Markert T, Vaandrager AB, Gambaryan S, Pohler D, Hausler C, Walter U, De Jonge HR, Jarchau T, Lohmann SM (1995) Endogenous expression of type II cGMP-dependent protein kinase mRNA and protein in rat intestine. Implications for cystic fibrosis transmembrane conductance regulator. J Clin Invest 96:822–830

    Google Scholar 

  • McDonald BJ, Moss SJ (1994) Differential phosphorylation of intracellular domains of γ-aminobutyric acid type A receptor subunits by calcium/calmodulin type 2-dependent protein kinase and cGMP-dependent protein kinase. J Biol Chem 269:18111–18117.

    Google Scholar 

  • McDonald BJ, Moss SJ (1997) Conserved phosphorylation of the intracellular domains of GABAA receptor β2 and β3 subunits by cAMP-dependent protein kinase, cGMP-dependent protein kinase C and Ca2+/calmodulin type II-dependent protein kinase. Neuropharmacology 36:1377–1385

    Google Scholar 

  • Miglietta LA, Nelson DL (1988) A novel cGMP-dependent protein kinase from Paramecium. J Biol Chem 263:16096–16105

    Google Scholar 

  • Mitchell RD, Glass DB, Wong CW, Angelos KL, Walsh DA (1995) Heat-stable inhibitor protein derived peptide substrate analogs: phosphorylation by cAMP-dependent and cGMP-dependent protein kinases. Biochemistry 34:528–534

    Google Scholar 

  • Miura Y; Kaibuchi K; Itoh T; Corbin JD; Francis SH; Takai Y (1992) Phosphorylation of smg p21B/rap1B p21 by cyclic GMP-dependent protein kinase. FEBS Lett 297:171–174

    Google Scholar 

  • Murofushi H (1974) Protein kinases in Tetrahymena cilia. II. Partial purification and characterization of adenosine 3′,5′-monophosphate-dependent and guanosine 3′,5′-monophosphate-dependent protein kinases. Biochim Biophys Acta 370:130–139

    Google Scholar 

  • Ogreid D, Ekanger R, Suva RH, Miller JP, Doskeland SO (1989) Comparison of the two classes of binding sites (A and B) of type I and type II cyclic-AMP-dependent protein kinases by using cyclic nucleotide analogs. Eur J Biochem 181:19–31

    Google Scholar 

  • Orstavik S, Solberg R, Tasken K, Nordahl M, Altherr MR, Hansson V, Jahnsen T, Sandberg M (1996) Molecular cloning, cDNA structure, and chromosomal localization of the human type II cGMP-dependent protein kinase. Biochem Biophys Res Commun 220:759–765

    Google Scholar 

  • Orstavik S; Sandberg M; Berube D; Natarajan V; Simard J; Walter U; Gagne R; Hansson V; Jahnsen T (1992) Localization of the human gene for the type I cyclic GMP-dependent protein kinase to chromosome 10. Cytogenet-Cell-Genet., 59, 270–273

    Google Scholar 

  • Osborne KA, Robichon A, Burgess E, Butland S, Shaw RA, Coulthard A, Pereira HS, Greenspan RJ, Sokolowski MB (1997) Natural behavior polymorphism due to a cGMP-dependent protein kinase of Drosophila. Science 277:834–836

    Google Scholar 

  • Pfeifer A, Aszódi A, Seidler U, Ruth P, Hofmann F, Fässler R (1996). Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II. Science 274:2082–2086

    Google Scholar 

  • Pfeifer A, Klatt P, Massberg S, Ny L, Sausbier M, Hirneiß C, Wang G-X, Korth M, Aszódi A, Andersson K-E, Krombach F, Mayerhofer A, Ruth P, Fässler R, Hofmann F (1998) Defective smooth muscle regulation in cGMP kinase I-deficient mice. EMBO J 17:3045–3051

    Google Scholar 

  • Pfitzer G, Hofmann F, DiSalvo J, Rüegg JC (1984) cGMP and cAMP inhibit tension development in skinned coronary arteries. Plügers Arch 401:277–280

    Google Scholar 

  • Pilz RB, Suhasini M, Idriss S, Meinkoth JL, Boss GR (1995) Nitric oxide and cGMP analogues activate transcription from AP-1-responsive promoters in mammalian cells. FASEB J 9:552–558

    Google Scholar 

  • Pöhler D, Butt E, Meissner J, Muller S, Lohse M, Walter U, Lohmann SM, Jarchau T (1995) Expression, purification, and characterization of the cGMP-dependent protein kinases I beta and II using the baculovirus system. FEBS Lett 374:419–425

    Google Scholar 

  • Pryzwansky KB, Kidao S, Wyatt TA, Reed W, Lincoln TM (1995) Localization of cyclic GMP-dependent protein kinase in human mononuclear phagocytes. J Leukoc Biol 57:670–678

    Google Scholar 

  • Qian Y, Chao DS, Santillano DR, Cornwell TL, Nairn AC, Greengard P, Lincoln TM, Bredt DS (1996) cGMP-dependent protein kinase in dorsal root ganglion: relationship with nitric oxide synthase and nociceptive neurons. J Neurosci 16:3130–3188

    Google Scholar 

  • Rannels SR, Corbin JD (1981) Two different intrachain cAMP binding sites of cAMP-dependent protein kinases. J Biol Chem 255:7085–7088

    Google Scholar 

  • Rapoport RM (1989) Cylic guanosine monophosphate inhibition of contraction may be mediated through inhibition of phosphatidyl inositol hydrolysis in rat aorta. Circ Res 58:407–410

    Google Scholar 

  • Rapoport RM, Draznin MB, Murad F (1982) Sodium nitroprusside-induced protein phosphorylation in intact rat aorta is mimicked by 8-bromo cyclic GMP. Proc Natl Acad Sci USA 79:6470–6474

    Google Scholar 

  • Raymond JL, Lisberger SG, Mauk MD (1996) The cerebellum: a neuronal learning machine. Science 272:1126–1131

    Google Scholar 

  • Reed RB, Sandberg M, Jahnsen T, Lohmann S, Francis S, Corbin J (1996) Fast and slow cyclic nucleotide-dissociation sites in cAMP-dependent protein kinase are transposed in type Iß cGMP-dependent protein kinase. J Biol Chem 271:17570–17575

    Google Scholar 

  • Reinhard M, Halbrügge M, Scheer U, Wiegand C, Jockusch BM, Walter U (1992) The 46/50 kDa phosphoprotein VASP purified from human platelets is a novel protein associated with actin filaments and focal contacts. Embo J 11:2063–2070

    Google Scholar 

  • Robertson BE, Schubert R, Hescheler J, Nelson MT (1993) cGMP-dependent protein kinase activates cAMP kinase-activated K+ channels in cerebral artery smooth muscle cells. Am J Physiol 265:C299–C303

    Google Scholar 

  • Ruth P, Landgraf W, Keilbach A, May B, Egleme C, Hofmann F (1991) The activation of expressed cGMP-dependent protein kinase isozymes I alpha and I beta is determined by the different amino-termini. Eur J Biochem 202:1339–1344

    Google Scholar 

  • Ruth P, Pfeifer A, Kamm S, Klatt P, Dostmann WRG, Hofmann F (1997). Identification of the amino acid sequences responsible for high affinity activation of cGMP kinase Iα. J Biol Chem 272:10522–10528

    Google Scholar 

  • Ruth P, Wang G-X, Boekhoff I, May B, Pfeifer A, Penner R, Korth M, Breer H, Hofmann F (1993) Transfected cGMP-dependent protein kinase suppresses calcium transients by inhibition of inositol 1,4,5-triphosphate production. Proc Natl Acad Sci USA 90:2623–2627

    Google Scholar 

  • Ruth P, Kamm S, Nau U, Pfeifer A, Hofmann F (1996) A cGMP kinase mutant with increased sensitivity to the protein kinase inhibitor peptide PKI(5–24). Biol Chem 377:513–520

    Google Scholar 

  • Sandberg M, Butt E, Nolte C, Fischer L, Halbrugge M, Beltman J, Jahnsen T, Genieser HG, Jastorff B, Walter U (1991) Characterization of Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3′,5′-monophosphorothioate (Sp-5,6-DCl-cBiMPS) as a potent and specific activator of cyclic-AMP-dependent protein kinase in cell extracts and intact cells. Biochemistry 279:521–527

    Google Scholar 

  • Sandberg M, Natarajan V, Ronander I, Kalderon D, Walter U, Lohmann S, Jahnsen T (1989) Molecular cloning and predicted full-length amino acid sequence of the type Iß isozyme of cGMP-dependent protein kinase from human placenta. FEBS Lett 255:321–329

    Google Scholar 

  • Sansom SC, Stockand JD, Hall D, Williams B (1997) Regulation of large calcium-activated potassium channels by protein phosphatase 2A. J Biol Chem 272:9902–9906

    Google Scholar 

  • Schaap P, van Ments-Cohen M, Soede RDM, Brandt R, Firtel RA, Dostmann W, Genieser HG, Jastorff B, van Haastert PJM (1993) Cell-permeable nonhydrolyzable cAMP derivatives as tools for analysis of signaling pathways controlling gene regulation in Dictyostelium. J Biol Chem 268:6323–6331

    Google Scholar 

  • Scholz H, Kurtz A (1993) Involvement of endothelium-derived relaxing factor in the pressure control of renin secretion from isolated perfused kidney. J Clin Invest 91:1088–1094

    Google Scholar 

  • Schulz S, Green CK, Yuen PS, Garbers DL (1990) Guanylyl cyclase is a heat-stable enterotoxin receptor. Cell 63:941–948

    Google Scholar 

  • Schuman EM, Madison DV (1991) A requirement for the intercellular messenger nitric oxide in long-term potentiation. Science 254:1503–1506

    Google Scholar 

  • Sekhar KR, Hatchett RJ, Shabb JB, Wolfe L, Francis SH, Wells JN, Jastorff B, Butt E Chakinala MM, Corbin JD (1992) Relaxation of pig coronary arteries by new and potent cGMP analogs that selectively activate type I alpha, compared with type I beta, cGMP-dependent protein kinase. Mol Pharm 42:103–108

    Google Scholar 

  • Shabb JB, Corbin JD (1992) Cyclic nucleotide-binding domains in proteins having diverse functions. J Biol Chem 267:5723–5726

    Google Scholar 

  • Shesely EG, Maeda N, Kim HS, Desai KM, Krege JH, Laubach VE, Sherman PA, Sessa WC, Smithies O (1996) Elevated blood pressure in mice lacking endothelial nitric oxide synthase. Proc Natl Acad Sci USA 93:13176–13181

    Google Scholar 

  • Shesely EG, Maeda N, Kim HS, Desai KM, Krege JH, Laubach VE, Sherman PA, Sessa WC, Smithies O (1996) Elevated blood pressure in mice lacking endothelial nitric oxide synthase. Proc Natl Acad Sci USA 93:13176–13181

    Google Scholar 

  • Shibuki K, Okada D (1991) Endogenous nitric oxide release required for long-term synaptic depression in the cerebellum. Nature 349:326–328

    Google Scholar 

  • Shirasawa S, Yunker AMR, Roth KA, Brown GA, Horning S, Korsmeyer SJ (1997) Enx (Hox11L1) deficient mice develop myenteric neuronal hyperplasia and megacolon. Nature Medicine 3:646–650

    Google Scholar 

  • Sicheri F, Moarefi I, Kuriyan J (1997) Crystal structure of the src family tyrosine kinase hck. Nature 385:602–609

    Google Scholar 

  • Siess W (1989) Molecular mechanisms of platelet activation. Physiol Rev 69:58–178

    Google Scholar 

  • Skalhegg BS, Landmark BF, Doskeland SO, Hansson V, Lea T, Jahnsen T (1992) Cyclic AMP-dependent protein kinase type I mediates the inhibitory effects of 3′,5′-cyclic adenosine monophosphate on cell replication in human T lymphocytes. J Biol Chem 267:15707–15714

    Google Scholar 

  • Smith JA, Francis SH, Walsh KA, Kumar S, Corbin JD (1996) Autophosphorylation of type Ibeta cGMP-dependent protein kinase increases basal catalytic activity and enhances allosteric activation by cGMP or cAMP. J Biol Chem 271:20756–20762

    Google Scholar 

  • Sokolowski MB (1980) Foraging strategies of Drosophila melanogaster: a chromosomal analysis. Behav Genet 10:291–302

    Google Scholar 

  • Sonnenburg WK, Beavo JA (1994) Cyclic GMP and regulation of cyclic nucleotide hydrolysis. Adv Pharmacol 26:87–114

    Google Scholar 

  • Steinberg RA, Cauthron RD, Symcox MM, Shuntoh H (1993) Autoactivation of catalytic (Cα) subunit of cyclic AMP-dependent protein kinase by phosphorylation of threonine 197. Mol Cell Biol 13:2332–2341

    Google Scholar 

  • Steinberg RA, Gorman KB, Øgreid D, Døskeland SO, Weber IT (1991) Mutations that alter charge of type I regulatory subunit and modify activation properties of cyclic AMP-dependent Protein Kinase from Mouse S49 Lymphoma cells. J Biol Chem 266:3547–3553

    Google Scholar 

  • Su Y, Dostmann WRG, Herberg FW, Durick K, Xuong N-H, Ten Eyck L, Taylor SS Varughese KI (1995) Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains. Science 269:807–813

    Google Scholar 

  • Suda M, Ogawa Y, Tanaka K, Tamura N, Yasoda A, Takigawa T, Uehira M, Nishimoto H, Itoh H, Saito Y, Shiota K, Nakao K (1998) Skeletal overgrowth in transgenic mice that overexpress brain natriuretic peptide. Proc Natl Acad Sci 95:2337–2342

    Google Scholar 

  • Suko J, Maurer-Fogy I, Plank B, Bertel O, Wyskovsky W, Hohenegger M, Hellmann G (1993) Phosphorylation of serine 2843 in ryanodine receptor-calcium release channel of skeletal muscle by cAMP-, cGMP-and CaM-dependent protein kinase. Biochim Biophys Acta 1175:193–206

    Google Scholar 

  • Takahashi SY, Kageyama T, Ohoka T, Ohnishi E (1974) Guanosine 3′,5′-monophosphate-dependent protein kinase from silkworm eggs: Purification and Properties. Insect Biochem 4:429–438

    Google Scholar 

  • Takio K, Wade RD, Smith SB, Krebs EG, Walsh KA, Titani K (1984) Guanosine cyclic 3′,5′-phosphate dependent protein kinase, a chimeric protein homologous with two separate protein families. Biochemistry 23:4207–4218

    Google Scholar 

  • Taniguchi J, Furukawa K-I, Shigekawa M (1993) Maxi K+ channels are stimulated by cyclic guanosine monophosphate-dependent protein kinase in canine coronary artery smooth muscle cells. Pflügers Arch 423:167–172

    Google Scholar 

  • Taylor SS, Radzio-Andzelm E (1994) Three protein kinase structures define a common motif. Structure 2:345–55

    Google Scholar 

  • Tegge W, Frank R, Hofmann F, Dostmann WRG (1995) Determination of cyclic nucleotide-dependent protein kinase substrate specificity by the use of peptide libraries on cellulose paper. Biochemistry 34:10569–10577

    Google Scholar 

  • Thomas MK, Francis SH, Corbin JD (1990) Substrate-and kinase-directed regulation of phosphorylation of a cGMP-binding phosphodiesterase by cGMP. J Biol Chem 265:14971–14978

    Google Scholar 

  • Turko IV, Francis SH, Corbin JD (1998) Binding of cGMP to both allosteric sites of cGMP-binding cGMP-specific phosphodiesterase (PDES) is required for its phosphorylation. Biochem J 329:505–510

    Google Scholar 

  • Uchida S, Sasaki S, Furukawa T, Hiraoka M, Imai T, Hirata Y, Marumo F (1993) Molecular cloning of a chloride channel that is regulated by dehydration and expressed predominantly in kidney medulla. J Biol Chem 268:3821–3824

    Google Scholar 

  • Uhler M (1993) Cloning and expression of a novel cyclic GMP-dependent protein kinase from mouse brain. J Biol Chem 268:13586–13591

    Google Scholar 

  • Vaandrager AB, Edixhoven M, Bot AGM, Kroos MA, Jarchau T, Lohmann SM, Genieser H-G, De Jonge HR (1997) Endogenous Type II cGMP-dependent protein kinase exists as a dimer in membranes and can be functionally distinquished from the type I isoforms. J Biol Chem 272:11816–11823

    Google Scholar 

  • Vaandrager AB, Ehlert EME, Jarchau T, Lohmann SM, De Jonge HR (1996) Nterminal myristoylation is required for membrane localization of cGMP-dependent protein kinase type II. J Biol Chem 271:7025–7029

    Google Scholar 

  • Vaandrager AB, Smolenski A, Tilly BC, Houtsmuller AB, Ehlert EME, Bot AGM, Edixhoven M, Boomaars WEM, Lohmann SM, De Jonge HR (1998) Membrane targeting of cGMP-dependent protein kinase is required for cystic fibrosis transmembrane conductance regulator Cl-channel activation. Proc Natl Acad Sci USA 95:1466–1471

    Google Scholar 

  • Vaandrager AB, van der Wiel E, De Jonge HR (1993) Heat-stable enterotoxin activation of immunopurified guanylyl cyclase C. Modulation by adenine nucleotides. J Biol Chem 268:19598–19603

    Google Scholar 

  • Van Epps-Fung C, Williams JP, Cornwell TL, Lincoln TM, McDonald JM, Radding W, Blair HC (1994) Regulation of osteoclastic acid secretion by cGMP-dependent protein kinase. Biochem Biophys Res Commun 204:565–571

    Google Scholar 

  • Vanderwinden J-M, Mailleux P, Schiffmann SN, Vanderhaeghen J-J, De Laet MH (1992) Nitric oxide synthase activity in infantile hypertrophic pyloric stenosis. N Engl J Med 327:511–515

    Google Scholar 

  • Wagner C, Pfeifer A, Ruth P, Hofmann F, Kurtz A (1998) Inhibitory role of cGMP-kinase II in the control of renin secretion and renin expression J Clin Invest (in press)

    Google Scholar 

  • Waldmann R, Bauer S, Göbel C, Hofmann F, Jakobs KH, Walter U (1986) Demonstration of cGMP-dependent protein kinase and cGMP-dependent phosphorylation in cell-free extracts of platelets. Eur J Biochem 158:203–208

    Google Scholar 

  • Wang G-R, Zhu Y, Halushka PV, Lincoln TM, Mendelsohn ME (1998) Mechanism of platelet inhibition by nitric oxide: In vivo phosphorylation of thromboxane receptor by cyclic GMP-dependent protein kinase. Proc Natl Acad Sci USA 95:4888–4893

    Google Scholar 

  • Wanner R, Wurster B (1990) Cyclic GMP-activated protein kinase from Dictyostelium discoideum. Biochim Biophys Acta 1053:179–184

    Google Scholar 

  • Weber IT, Shabb JB, Corbin HD (1989) Predicted structures of the cGMP-dependent protein kinase: A key Alanine/threonine difference in evolutionary divergence of cAMP and cGMP binding sites. Biochemistry 28:6122–6127

    Google Scholar 

  • Weber IT, Steitz TA (1987) Structure of a complex of catabolite gene activator protein and cyclic AMP refined at 2.5 Å resolution. J Mol Biol 198:311–326

    Google Scholar 

  • Weber IT, Takio K, Titani K, Steitz TA (1982) The cAMP-binding domains of the regulatory subunit of cAMP-dependent protein kinase and the catabolite gene activator protein are homologues. Proc Natl Acad Sci USA 79:7679–7683

    Google Scholar 

  • Weisskopf MG, Castillo PE, Zalutsky RA, Nicoll RA (1994) Mediation of hippocampal mossy fiber long-term potentiation by cyclic AMP. Science 265:1878–1882

    Google Scholar 

  • Wen W, Taylor S (1994) High-affinity binding of the heat-stable protein kinase inhibitor to the catalytic subunit of cAMP-dependent protein kinase is selectively abolished by mutation of Arg133. J Biol Chem 269:8423–8430

    Google Scholar 

  • Wernet W, Flockerzi V, Hofmann F (1989) The cDNA of the two isoforms of bovine cGMP-dependent protein kinase. FEBS Lett 251:191–196

    Google Scholar 

  • White RE, Lee AB, Shcherbatko AD, Lincoln TM, Schonbrunn A, Armstrong DL (1993) Potassium channel stimulation by natriuretic peptides through cGMP-dependent dephosphorylation. Nature 361:263–266

    Google Scholar 

  • Wolfe L, Francis SH, Corbin JD (1989) Properties of a cGMP-dependent monomeric protein kinase from bovine aorta. J Biol Chem 264:4157–4162

    Google Scholar 

  • Wood JS; Yan X; Mendelow M; Corbin D; Francis SH, Lawrence DS (1996) Precision substrate targeting of protein kinases. The cGMP-and cAMP-dependent protein kinases. J Biol Chem 271:174–179

    Google Scholar 

  • Wyatt TA, Lincoln TM, Pryzwansky KB (1991) Vimentin is transiently co-localized with and phosphorylated by cyclic GMP-dependent protein kinase in formylpeptide-stimulated neutrophils. J Biol Chem 266:21274–21820

    Google Scholar 

  • Xu RM, Carmel G, Kuret J, Cheng X (1996) Structural basis for selectivity of the isoquinoline sulfonamide family of protein kinase inhibitors. Proc Natl Acad Sci USA 93:6308–6313

    Google Scholar 

  • Yan X, Corbin JD, Francis SH, Lawrence, DS (1996) Precision targeting of protein kinases. An affinity label that inactivates the cGMP-but not the cAMP-dependent protein kinase. J Biol Chem 271:1845–1848

    Google Scholar 

  • Yeaman SJ, Cohen P, Watson DC, Dixon GH (1977) The substrate specificity of adenosine 3′:5′-cyclic monophosphate-dependent protein kinase of rabbit skeletal muscle. Biochem J 162:411–421

    Google Scholar 

  • Yokozaki H, Tortora G, Pepe S, Maronde E, Genieser HG, Jastorff B, Cho-Chung YS (1992) Unhydrolyzable analogues of adenosine 3′:5′-monophosphate demonstrating growth inhibition and differentiation in human cancer cells. Cancer Res 52:2504–2508

    Google Scholar 

  • Yu S-M, Hung L-M, Lin C-C (1997) cGMP-eleating agents suppress proliferation of vascular smooth muscel cells by inhibiting the activation of epidemral growth factor signaling pathway. Circulation 95:1269–1277

    Google Scholar 

  • Zhao J, Trewhella J, Corbin J, Francis S, Mitchell R, Bushin R, Walsh D (1997) Progressive cyclic nucleotide-induced conformational changes in the cGMP-dependent protein kinase studied by small angle x-ray scattering in solution. J Biol Chem 272:31929–31936

    Google Scholar 

  • Zheng J, Knighton DR, ten Eyck LF, Karlsson R, Xuong N, Taylor SS, Sowadski JM (1993) Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor. Biochemistry 32:2154–2161

    Google Scholar 

  • Zhuo M, Hu Y, Schultz C, Kandel ER, Hawkins RD (1994) Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation. Nature 368:635–639

    Google Scholar 

  • Zhou X-B, Ruth P, Schlossmann J, Hofmann F, Korth M (1996) Protein phosphatase 2A is essential for the activation of Ca2+ activated K+ channels currents by cGMP-dependent protein kinase in tracheal smooth muscle and chinese hamster ovary cells. J Biol Chem 271:19760–19767

    Google Scholar 

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Pfeifer, A., Ruth, P., Dostmann, W., Sausbier, M., Klatt, P., Hofmann, F. (1999). Structure and function of cGMP-dependent protein kinases. In: Reviews of Physiology, Biochemistry and Pharmacology, Volume 135. Reviews of Physiology, Biochemistry and Pharmacology, vol 135. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0033671

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