Skip to main content
SpringerLink
Log in
Book cover

Reviews of Physiology, Biochemistry and Pharmacology, Volume 121 pp 31–48Cite as

The hypothalamic hormone oxytocin: From gene expression to signal transduction

  • Chapter
  • First Online:

Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology ((REVIEWS,volume 121))

This is a preview of subscription content, log in via an institution.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Akaishi T, Sakuma Y (1985) Estrogen excites oxytocinergic but not vasopressinergic cells in the paraventricular nucleus of female rat hypothalamus. Brain Res 335:302–305

    Google Scholar 

  • Antoni FA (1986) Oxytocin receptors in rat adenohypophysis: evidence from radioligand binding studies. Endocrinology 119:2393–2395

    Google Scholar 

  • Audigier S, Barberis C (1985) Pharmacological characterization of two specific binding sites for neurohypophyseal hormones in hippocampal synaptic plasma membranes of the rat. EMBO J 4: 1407–1412

    Google Scholar 

  • Bargmann W (1966) Neurosecretion. Int Rev Cytol 19:183–201

    Google Scholar 

  • Barr PJ (1991) Mammalian subtilisins: the long-sought dibasic processing endoproteases. Cell 66:1–3

    Google Scholar 

  • Barr PJ, Mason OB, Landsberg KE, Wong PA, Kiefer MC, Brake AJ (1991) cDNA and gene structure for a human subtilisin-like protease with cleavage specifitiy for paired basic amino acid residues. DNA Cell Biol 10:319–328

    Google Scholar 

  • Bradbury AF, Smyth DG (1991) Peptide amidation. TIBS 16:112–115

    Google Scholar 

  • Bradbury AF, Finnie MDA, Smyth DG (1982) Mechanism of C-terminal amide formation by pituitary enzymes. Nature 298:686–688

    Google Scholar 

  • Cantau B, Barjon NJ, Chicot D, Baskevitch PP, Jard S (1990) Oxytocin receptors from LLC-PK1 cells: expression in oocytes. Am J Physiol 258:F963–972

    Google Scholar 

  • Carsten ME, Miller JD (1985) Ca2+ release by inositol trisphosphate from Ca2+ transporting microsomes derived from uterine sarcoplasmic reticulum. Biochem Biophys Res Commun 130:1027–1031

    Google Scholar 

  • Chadio SE, Antoni FA (1989) Characterization of oxytocin receptors in rat adenohypophysis using a radioiodinated receptor antagonist peptide. J Endocrinol 122:465–470

    Google Scholar 

  • Charpak S, Armstrong WE, Mühlethaler M. Dreifuss JJ (1984) Stimulatory action of oxytocin on neurones of the dorsal motor nucleus of the vagus nerve. Brain Res 300:83–89

    Google Scholar 

  • Chauvet MT, Hurpet D, Chauvet J, Acher R (1983) Identification of human neurophysins: complete amino acid sequences of MSEL-and VLDV-neurophysins. Proc Natl Acad Sci USA 80:2839–2843

    Google Scholar 

  • Clamigirand C, Creminan C, Fahy C, Boussetta H, Cohen P (1987) Partial purification and functional properties of an endopeptidase from bovine neurosecretory granules cleaving prooxytocin/neurophysin peptides at the basic amino acid doublet. Biochemistry 26:6018–6023

    Google Scholar 

  • Colpaert FC, Wiepkema PR (1976) Effect of ventromedial hypothalamic lesions on spontaneous intraspecies aggression in male rats. Behav Biol 16:117–125

    Google Scholar 

  • Dale HH (1906) On some physiological actions of ergot. J Physiol (Lond) 34:163–206

    Google Scholar 

  • Davis L, Banker GA, Steward O (1987) Selective dendritic transport of RNA in hippocampal neurons in culture. Nature 330:477–479

    Google Scholar 

  • de Kloet ER, Voorhuis DAM, Boschma Y, Elands S (1986) Estradiol modulates density of putative ‘oxytocin receptors’ in discrete rat brain regions. Neuroendocrinology 44:415–421

    Google Scholar 

  • Dierickx K, Vandesande F (1979) Immunocytochemical demonstration of separate vasopressin-neurophysin and oxytocin-neurophysin neurons in the human hypothalamus. Cell Tissue Res 196:203–212

    Google Scholar 

  • Dirks RW, Raap AK, van Minnen J, Vreugdenhil E, Smit AB, van der Ploeg M (1989) Detection of mRNA molecules coding for neuropeptide hormones of the pond snail Lymnaea stagnalis by radioactive and non-radioactive in situ hybridization: a model study for mRNA detection. J Histochem Cytochem 37:7–14

    Google Scholar 

  • Di Scala-Guenot D, Strosser MT, Freund-Mercier MR, Richard P (1990) Characterization of oxytocin-binding sites in primary rat brain cell cultures. Brain Res 524:10–16

    Google Scholar 

  • Egan JJ, Saltis J, Wek SA, Simpson IA, Londos C (1990) Insulin, oxytocin and vasopressin stimulate protein kinase C activity in adipocyte plasma membranes. Proc Natl Acad Sci USA 87:1052–1056

    Google Scholar 

  • el Alj A, Bonoris E, Cynoher E, Germain G (1990) Heterogeneity of oxytocin receptors in the pregnant rat myometrium near parturition. Eur J Pharmacol 186:231–238

    Google Scholar 

  • Elands J, Resnik A, de Kloet ER (1990) Neurohypophyseal hormone receptors in the rat thymus, spleen, and lymphocytes. Endocrinology 126:2703–2710

    Google Scholar 

  • Elands J, Beetsma A, Barberis C, De Kloet ER (1988) Topography of the oxytocin receptor system in rat brain: an autoradiographical study with a selective radioiodinated oxytocin antagonist. J Chem Neuroanatom 1:293–302

    Google Scholar 

  • Evans JJ, Catt KJ (1989) Gonadotrophin-releasing activity of neurohypophyseal hormones: II. the pituitary oxytocin receptor mediating gonadotrophin release differs from that of corticotrophs. J Endocrinol 122:107–116

    Google Scholar 

  • Fahrenholz F, Hackenberg M, Müller M (1988) Identification of a myometrial oxytocin receptor protein. Eur J Biochem 174:81–85

    Google Scholar 

  • Forsling ML (1986) Regulation of oxytocin release. In: Current Topics in Neuroendocrinology 6. Neurobiology of Oxytocin. Springer, Berlin Heidelberg New York, pp 19–54

    Google Scholar 

  • Forsling ML, Brimble MJ (1985) The role of oxytocin in salt and water balance. In: Oxytocin: clinical and laboratory studies. Elsevier, Amsterdam, pp 167–175

    Google Scholar 

  • Fricker LD, Snyder SH (1983) Purification and characterization of enkephalin convertase, an enkephalin synthesizing carboxypeptidase. Eur J Biol Chem 258:10950–10955

    Google Scholar 

  • Fricker LD, Evans CJ, Esch FS, Herbert E (1986) Cloning and sequence analysis of cDNA for bovine carboxypeptidase E. Nature 323:461–464

    Google Scholar 

  • Fuller RS, Brake AJ, Thorner J (1989) Intracellular targeting and structural conservation of a prohormone-processing endoprotease. Science 246:482–486

    Google Scholar 

  • Gainer H, Sarne Y, Brownstein MJ (1977a) Neurophysin biosynthesis: conversion of a putative precursor during axonal transport. Science 195:1354–1356

    Google Scholar 

  • Gainer H, Sarne Y, Brownstein MJ (1977b) Biosynthesis and axonal transport of rat neurohypophysial proteins and peptides. J Cell Biol 73:366–381

    Google Scholar 

  • Gibson A, Shaw CR (1989) The effect of Ca-deprivation and of Ca-blocking drugs on oxytocin-induced contractions of the male mouse anococcygeus. J Pharm Pharmacol 41:412–415

    Google Scholar 

  • Giuditta A, Metafora S, Felsoni A, Del Rio A (1977) Factors for protein synthesis in the axoplasm of squid giant axons. J Neurochem 28:1393–1395

    Google Scholar 

  • Giuditta A, Menichini E, Castigli E, Perrone Capano C (1990) Protein synthesis in the axonal territory. In: Neurology and Neurobiology 59. Stella AMG, de Vellis J, and Perez-Polo JR (eds) Regulation of Gene Expression in the Nervous System. Wiley, New York, pp 205–218

    Google Scholar 

  • Giuditta A, Menichini E, Capano CP, Langella M, Martin R, Castigli E, Kaplan BB (1991) Active polysomes in the axoplasm of the squid giant axon. J Neurosci Res 28:18–28

    Google Scholar 

  • Gordon-Weeks PR (1988) RNA transport in dendrites. Trends Neurosci 11:342–343

    Google Scholar 

  • Hara Y, Battey J, Gainer H (1990) Structure of the mouse vasopressin and oxytocin genes. Mol Brain Res 8:319–324

    Google Scholar 

  • Heierhorst J, Morley SD, Figueroa J, Krentler C, Lederis K, Richter D (1989) Vasotocin and isotocin precursors from the white sucker Catostomus commersoni: cloning and sequence analysis of the cDNAs. Proc Natl Acad Sci USA 86:5242–5246

    Google Scholar 

  • Hixon JE, Flint AP (1987) Effects of a luteolytic dose of oestradiol benzoate on uterine oxytocin receptor concentration, phosphoinositide turnover and prostaglandin F2α secretion in sheep. J Repr Fertil 79:457–467

    Google Scholar 

  • Ingram CD, Cutler KL, Wakerley JB (1990) Oxytocin excites neurones in the bed nucleus of the stria terminalis of the lactating rat in vitro. Brain Res 527:167–170

    Google Scholar 

  • Ivell R (1986) Biosynthesis of oxytocin in the brain and peripheral organs. In: Neurobiology of Oxytocin. Springer, Berlin Heidelberg New York, pp 1–18 (Current topics in neuroendocrinology vol 6)

    Google Scholar 

  • Ivell R, Richter D (1984) Structure and comparison of the oxytocin and vasopressin genes from rat. Proc Natl Acad Sci USA 81:2006–2010

    Google Scholar 

  • Jacobson C, Riemer RK, Goldfien AC, Lykins D, Siiteri PK, Roberts JM (1987) Rabbit myometrial oxytocin and alpha2-adrenergic receptors are increased by estrogen but are differentially regulated by progesterone. Endocrinology 120:1184–1189

    Google Scholar 

  • Jard S, Gaillard RC, Guillon G, Marie J, Schoenenberg P, Muller AF, Manning M, Sawyer WK (1986) Vasopressin antagonists allow demonstration of a novel type of vasopressin receptor in the rat adenohypophysis. Mol Pharmacol 30:171–177

    Google Scholar 

  • Jard S, Barberis C, Audigier S, Tribollet E (1987) Neurohypophyseal hormone receptor systems in brain and periphery. In: de Kloet ER, Weigant VM, de Wied D (eds) Prog Brain Res 72:173–186

    Google Scholar 

  • Johnson MH, Everitt BJ (1984) Essential reproduction, 2nd edn. pp 300–327 Blackwell Scientific Publications, Oxford

    Google Scholar 

  • Koenig E (1979) Ribosomal RNA in Mauthner axon: implications for a protein synthesizing machinery in the myelinated axon. Brain Res 174:95–107

    Google Scholar 

  • Kovacs GL (1986) Oxytocin and behaviour. In: Ganten D, Pfaff D (eds) Neurobiology of oxytocin. Springer, Berlin Heidelberg New York, pp 91–128

    Google Scholar 

  • Kursheed A, Sanborn BM (1989) Changes in intracellular free calcium in isolated myometrial cells: role of extracellular and intracellular calcium and possible involvement of guanine nucleotide-sensitive proteins. Endocrinology 124:17–23

    Google Scholar 

  • Lasek RJ, Brady ST (1981) The axon: a prototype for studying expressional cytoplasm. Cold Spring Harbor Symp Quant Biol 46:113–124

    Google Scholar 

  • Leavitt WW, Okulicz WC, McCracken JA, Schramm W, Robidoux WT (1985) Rapid recovery of nuclear estrogen receptor and oxytocin receptor in the ovine uterus following progesterone withdrawal. J Steroid Biochem 22:687–691

    Google Scholar 

  • Lederis K, Goren HJ, Hollenberg MD (1985) Oxcytocin: an insulin-like hormone. In: Amico LA, Robinson AG (eds) Oxytocin: clinical and laboratory studies. Elsevier, Amsterdam, pp 284–302

    Google Scholar 

  • Marc S, Leiber D, Harbon S (1986) Carbachol and oxytocin stimulate generation of inositol phosphate in guinea pig myometrium. FEBS Lett 201:9–14

    Google Scholar 

  • Marc S, Leiber D, Harbon S (1988) Fluoroaluminates mimic muscarinic-and oxytocin-receptor-mediaded generation of inositol phosphates and contraction in the intact guineapig myometrium. Biochem J 255:705–713

    Google Scholar 

  • Meyerhof W, Morley S, Schwarz J, Richter D (1988) Receptors for neuropeptides are induced by exogenous poly(A)+RNA in oocytes from Xenopus laevis. Proc Natl Acad Sci USA 85:714–717

    Google Scholar 

  • Miller FD, Ozimek G, Milner RJ, Bloom FE (1989) Regulation of neuronal oxytocin mRNA by ovarian steroids in the mature and developing hypothalamus. Proc Natl Acad Sci USA 86:2468–2472

    Google Scholar 

  • Mohr E, Schmitz E (1991) Functional characterization of estrogen and glucocorticoid responsive elements in the rat oxytocin gene. Mol Brain Res 9:293–298

    Google Scholar 

  • Mohr E, Schmitz E, Richter D (1988) A single rat genomic DNA fragment encodes both the oxytocin and vasopressin genes separated by 11 kilobases and oriented in opposite transcriptional directions. Biochimie 70:649–654

    Google Scholar 

  • Mohr E, Fehr S, Richter D (1991) Axonal transport of neuropeptide encoding mRNAs within the hypothalamo-hypophyseal tract of rats. EMBO J 10:2419–2424

    Google Scholar 

  • Morley SD, Meyerhof W, Schwarz J, Richter D (1988) Functional expression of the oxytocin receptor in Xenopus laevis oocytes primed with mRNA from bovine endometrium. J Mol Endocrinol 1:77–81

    Google Scholar 

  • Morley SD, Schönrock C, Heierhorst J, Figueroa J, Lederis K, Richter D (1990) Vasotocin genes in the teleost fish Catostomus commersoni: gene structure, exon-intron boundery, and hormone precursor organization. Biochemistry 29:2506–2511

    Google Scholar 

  • Mühlethaler M, Sawyer WH, Manning MM, Dreifuss JJ (1983) Characterization of a uterine type oxytocin receptor in the rat hippocampus. Proc Natl Acad Sci USA 80:6713–6717

    Google Scholar 

  • Müller M, Soloff MS, Fahrenholz F (1989) Photoaffinity labelling of the oxytocin receptor in plasma membranes from rat mammary glands. FEBS Lett 242:333–336

    Google Scholar 

  • Nance DM (1976) Sex difference in the hypothalamic regulation of feeding behaviour in the rat. Adv Psychol 3:75–123

    Google Scholar 

  • Negoro H, Vissesuwan S, Holland RC (1973) Unit activity in the paraventricular nucleus of female rats at different stages of the reproductive cycle and after ovariectomy, with or without oestrogen or progesterone treatment. J Endocrinol 59:545–558

    Google Scholar 

  • Nicholson HD, Swann RW, Burford GD, Wathes DC, Porter GD, Pickering BT (1984) Identification of oxytocin and vasopressin in the testis and in adrenal tissue. Regul Pept 8:141–146

    Google Scholar 

  • Nörenberg U, Richter D (1988) Processing of oxytocin precursor: isolation of an exopeptidase from neurosecretory granules of bovine pituitaries. Biochim Biophys Res Comm 156:898–904

    Google Scholar 

  • Okabe T, Goren JH, Lederis K, Hollenberg MD (1985) Oxytocin and glucose oxidation in the rat uterus. Regul Pept 10:269–279

    Google Scholar 

  • Okazaki ME, Sagawa N, Okita JR, Bleasdale JE, MacDonald PC, Johnston JM (1981) Diacylglycerol metabolism and arachidonic acid release in human fetal membranes and decidua cells. J Biol Chem 256:7316–7321

    Google Scholar 

  • Olson BR, Drutarosky MD, Stricker EM, Verbalis JG (1991) Brain oxytocin receptor antagonism blunts the effect of anorexigenic treatments in rats: evidence for central oxytocin inhibition of food intake. Endocrinology 129:785–791

    Google Scholar 

  • Ott I, Scott JC (1910) The action of infundibulin upon the mammary secretion. Proc Soc Exp Biol Med 8:48–49

    Google Scholar 

  • Pfaff DW (1983) Impact of estrogens on hypothalamic nerve cells: ultrastructural, chemical and electrical effects. Recent Prog Horm Res 39:127–179

    Google Scholar 

  • Popescu LM, Nutu O, Panoiu C (1985) Oxytocin contracts the human uterus at term by inhibiting the myometrial Ca2+ extrusion pump. Biosci Rep 5:21–28

    Google Scholar 

  • Raggenbass M, Tribollet E, Dubois-Dauphin M, Dreifuss JJ (1989) Correlation between oxytocin neuronal sensitivity and oxytocin receptor binding: an electrophysiological and autoradiographical study comparing rat and guinea pig hippocampus. Proc Natl Acad Sci USA 86:750–754

    Google Scholar 

  • Rehbein M, Hillers M, Mohr E, Ivell R, Morley S, Schmale H, Richter D (1986) The neurohypophyseal hormones vasopressin and oxytocin: precursor structure, synthesis, and regulation. Biol Chem 367:695–704

    Google Scholar 

  • Rhodes CH, Morell JI, Pfaff DW (1981) Distribution of estrogen-concentrating, neurophysin-containing magnocellular neurons in the rat hypothalamus as demonstrated by a technique combining steroid autoradiography and immunohistology in the same tissue. Neuroendocrinology 33:18–23

    Google Scholar 

  • Richter D, Meyerhof W, Buck F, Morley SD (1991) Molecular biology of receptors for neuropeptide receptors. Curr Top Pathol 83:117–139

    Google Scholar 

  • Rivera J, Lopez Bernal A, Varney M, Watson SP (1990) Inositol 1,4,5-trisphosphate and oxytocin binding in human myometrium. Endocrinology 127:155–162

    Google Scholar 

  • Roberts JS, McCracken JA, Gavagan JE, Soloff Ms (1976) Oxytocin-stimulated release of prostaglandin F2α from ovine endometrium in vitro: correlation with estrous cycle and oxytocin-receptor binding. Endocrinonolgy 99:1107–1114

    Google Scholar 

  • Ruppert S, Scherer G, Schütz G (1984) Recent gene conversion involving bovine vasopressin and oxytocin precursor genes suggested by nucleotide sequence. Nature 308:554–557

    Google Scholar 

  • Sausville E, Carney D, Battey J (1985) The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line. J Biol Chem 260:10236–10241

    Google Scholar 

  • Sawyer WH, Grzonka Z, Manning M (1981) Design of tissue specific agonists and antagonists. Mol Cell Endocrinol 22:117–134

    Google Scholar 

  • Schams D, Schallenberg E, Meyer HHD, Bullermann B, Breitinger HJ, Euzenhofer G, Koll R, Kruip TAM, Walter DC, Karg H (1985) Ovarian oxytocin during the estrous cycle in cattle. In: Amico JA, Robinson AG (eds) Oxytocin, clinical and laboratory studies. Elsevier, Amsterdam, pp 317–334

    Google Scholar 

  • Scharrer E, Scharrer B (1940) Secretory cells within the hypothalamus. Res Publ Assoc Res Nerv Ment Dis 20:170–194

    Google Scholar 

  • Schmale H, Heinsohn S, Richter D (1983) Structural organization of the rat gene for the arginine vasopressin-neurophysin precursor. EMBO J 2:763–767

    Google Scholar 

  • Schmidt A, Dreifuss JJ, Tribollet E (1991) Oxytocin receptors in rat kidney during development. Am J Physiol 259:872–881

    Google Scholar 

  • Schrey MP, Read AM, Steer PJ (1986) Oxytocin and vasopressin stimulate inositol phosphate production in human gestational myometrium and decidua cells. Biosci Rep 6:613–619

    Google Scholar 

  • Sheldrick EL, Flint AP (1985) Endocrine control of uterine oxytocin receptors in the ewe. J Endocrinol 106:249–258

    Google Scholar 

  • Soloff MS, Fernstrom MA (1987) Solubilization and properties of oxytocin receptors from rat mammary gland. Endocrinology 120:2474–2482

    Google Scholar 

  • Soloff MS, Fields MJ (1989) Changes in uterine oxytocin receptor concentrations throughout the estrous cycle of the cow. Biol Reprod 40:283–287

    Google Scholar 

  • Soloff MS, Sweet P (1982) Oxytocin inhibition of (Ca2+ + Mg2+)ATPase activity in rat myometrial plasma membranes. J Biol Chem 257:10687–10693

    Google Scholar 

  • Soloff MS, Beauregard G, Potier M (1988) Determination of the functional size of oxytocin receptor from mammary gland and uterine myometrium of the rat by radiation analysis. Endocrinology 122:1769–1772

    Google Scholar 

  • Stassen FL, Heckman G, Schmidt D, Papadopoulos MT, Nambi P, Sarau H, Aiyar N, Gellai M, Kinter L (1988) Oxytocin induces a transient increase in cytosolic free [Ca2+] in renal tubular epithelial cells: evidence for oxytocin receptors on LLC-PK1 cells. Mol Pharmacol 33:218–224

    Google Scholar 

  • Stoeckel ME, Freund-Mercier MJ, Palacios JM, Richard P, Porte A (1987) Autoradiographic localization of binding sites for oxytocin and vasopressin in the rat kidney. J Endocrinol 113:179–182

    Google Scholar 

  • Swanson LW, Sawchenko PE (1983) Hypothalamic integration: organization of the paraventricular and supraoptic nuclei. Ann Rev Neurosci 6:269–324

    Google Scholar 

  • Takeda A, Leavitt WW (1986) Temporal effects of progesterone on estrogen and oxytocin receptor in hamster uterus. J Steroid Biochem 25:219–224

    Google Scholar 

  • Teitelbaum I (1991) Vasopressin-stimulated phosphoinositide hydrolysis in cultured rat inner medullary collecting duct cells is mediated by the oxytocin receptor. J Clin Invest 87:2122–2126

    Google Scholar 

  • Tence M, Guillon G, Bottari S, Jard S (1990) Labelling of vasopressin and oxytocin receptors from the human uterus. Eur J Pharmacol 191:427–436

    Google Scholar 

  • Tribollet E, Barberis C, Jard S, Dubois-Dauphin M, Dreifuss JJ (1988) Localization and pharmacological characterization of high affinity binding sites for vasopressin and oxytocin in the rat brain by light microscopic autoradiography. Brain Res 442:105–118

    Google Scholar 

  • Tucker RP, Garner CC, Matus A (1989) In situ localization of microtubule-associated protein mRNA in the developing and adult rat brain. Neuron 2:1245–1256

    Google Scholar 

  • Van Minnen J, Schallig HDFH (1990) Demonstration of insulin-related substances in the central nervous system of pulmonates and Aplysia californica. Cell Tissue Res 260:381–386

    Google Scholar 

  • Van Tol HHM, Voorhuis DTAM, Burbach JPH (1987) Oxytocin gene expression in discrete hypothalamic magnocellular cell groups is stimulated by prolonged salt loading. Endocrinology 120:71–76

    Google Scholar 

  • Van Tol HHM, Bolwerk ELM, Lin B, Burbach JPH (1988) Oxytocin and vasopressin gene expression in the hypothalamo-neurohypophyseal system of the rat during the estrous cycle, pregnancy, and lactation. Endocrinology 122:945–951

    Google Scholar 

  • Verbalis JG, Mangione MP, Stricker EM (1991) Oxytocin produces natriuresis in rats at physiological plasma concentrations. Endocrinology 128:1317–1322

    Google Scholar 

  • Walter P, Blobel G (1981) Translocation of proteins across the endoplasmic reticulum. II. Signal recognition protein (SRP) mediates the selective binding to microsomal membranes of in vitro assemble polysomes synthesizing secretory protein. J Cell Biol 91:551–556

    Google Scholar 

  • Wathes DC (1984) Possible actions of gonadal oxytocin and vasopressin. J Reprod Fertil 71:315–345

    Google Scholar 

  • Wathes DC, Swann RW, Pickering BT (1984) Variations in oxytocin, vasopressin and neurophysin concentrations in the bovine ovary during the estrous cycle and pregnancy. J Reprod Fertil 71:551–557

    Google Scholar 

  • Wilson T, Liggins GC, Whittaker DK (1988) Oxytocin stimulates the release of arachidonic acid and prostaglandin F2alpha from human decidual cells. Prostaglandins 35:771–780

    Google Scholar 

  • Windmoller R, Lye SJ, Challis JR (1983) Estradiol modulation of ovine uterine activity. Can J Physiol Pharmacol 61:722–728

    Google Scholar 

  • Wise RJ, Barr PB, Wong PA, Kiefer MC, Brake AJ, Kaufmann RJ (1990) Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site. Proc Natl Acid Sci USA 87:9378–9382

    Google Scholar 

  • Yamaguchi K, Akaishi T, Negoro H (1979) Effect of estrogen treatment on plasma oxytocin and vasopressin in ovariectomized rats. Endocrinol Jpn 26:197–205

    Google Scholar 

  • Yoshinaga K, Hawkins RA, Stocker JF (1969) Estrogen secretion by the rat ovary in vivo during the estrous cycle and pregnancy. Endocrinology 85:103–112

    Google Scholar 

  • Young WS III, Reynolds K, Shepard EA, Gainer H, Castel M (1990) Cell-specific expression of the rat oxytocin gene in transgenic mice. J Neuroendocrinol 2:917–925

    Google Scholar 

  • Zhao X, Gorewit RC (1987) Inositol-phosphate response to oxytocin stimulation in dispersed bovine mammary cells. Neuropeptides 10:227–233

    Google Scholar 

  • Zingg HH, Lefebvre DL (1988) Oxytocin and vasopressin gene expression during gestation and lactation. Mol Brain Res 4:1–6

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut für Zellbiochemie und klinische Neurobiologie, UKE, Universität Hamburg, D-2000, Hamburg 20, FRG

    Evita Mohr, Wolfgang Meyerhof & Dietmar Richter

Authors
  1. Evita Mohr
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wolfgang Meyerhof
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Dietmar Richter
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag

About this chapter

Cite this chapter

Mohr, E., Meyerhof, W., Richter, D. (1992). The hypothalamic hormone oxytocin: From gene expression to signal transduction. In: Reviews of Physiology, Biochemistry and Pharmacology, Volume 121. Reviews of Physiology, Biochemistry and Pharmacology, vol 121. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0033193

Download citation

  • DOI: https://doi.org/10.1007/BFb0033193

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-55969-6

  • Online ISBN: 978-3-540-47334-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation