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Cellular control of renin secretion

  • Armin Kurtz
Chapter
Part of the Reviews of Physiology, Biochemistry and Pharmacology book series (volume 113)

Abstract

In this review, present knowledge of the cellular regulation of renin secretion from renal juxtaglomerular cells has been considered. It appears that calcium is the dominant intracellular regulator of renin secretion and that it acts by inhibiting exocytosis. How calcium exerts this effect is not yet clear, but contraction of myofilaments, opening of chloride channels, and activation of PLA2 could be involved. C-kinase activation and cGMP seem to have an additional inhibitory effect on renin secretion, both in a calcium-dependent fashion. cAMP, on the other hand, stimulates secretion, presumably by decreasing intracellular calcium activity. GTP-binding proteins and electrical properties also seem to be involved in the control of renin secretion.

Present knowledge suggests that exocytosis in renal juxtaglomerular cells is regulated by mechanisms which differ from those of other secretory cells, where calcium and C kinase stimulate exocytosis. Revealing the reason for this unusual behavior remains a thrilling task for future research.

Keywords

Atrial Natriuretic Peptide Renin Release Renin Secretion Cellular Control Juxtaglomerular Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • Armin Kurtz
    • 1
  1. 1.Physiologisches Institut der Universität ZürichZürichSwitzerland

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