Hyperpolarization-activated cation channels: A multi-gene family

  • M. Biel
  • A. Ludwig
  • X. Zong
  • F. Hofmann
Part of the Reviews of Physiology, Biochemistry and Pharmacology book series (volume 136)


Since the first discovery of an Ih current in heart pacemaker cells about twenty years ago our knowledge on this ion channel class has increased substantially. Studies from a variety of groups have clearly demonstrated that Ih is not only required for cardiac pacemaking but also is a key regulator of several neuronal functions. The long-sought molecular cloning of the genes underlying Ih has now provided the basis to achieve a deeper understanding of the molecular function and physiological regulation of these channels. In addition, the powerful approaches of mouse genetics will enable us to study the physiological roles of the channels in significantly more detail than it was possible up to now.


Sinoatrial Node Tiger Salamander Catabolite Activator Protein Sinoatrial Node Cell Rabbit Sinoatrial Node Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 1999

Authors and Affiliations

  • M. Biel
    • 1
  • A. Ludwig
    • 1
  • X. Zong
    • 1
  • F. Hofmann
    • 1
  1. 1.Institut für Pharmakologie und Toxikologie der Technischen Universität MünchenMünchenGermany

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