Hyperpolarization-activated cation channels: A multi-gene family
- 68 Downloads
Since the first discovery of an Ih current in heart pacemaker cells about twenty years ago our knowledge on this ion channel class has increased substantially. Studies from a variety of groups have clearly demonstrated that Ih is not only required for cardiac pacemaking but also is a key regulator of several neuronal functions. The long-sought molecular cloning of the genes underlying Ih has now provided the basis to achieve a deeper understanding of the molecular function and physiological regulation of these channels. In addition, the powerful approaches of mouse genetics will enable us to study the physiological roles of the channels in significantly more detail than it was possible up to now.
KeywordsSinoatrial Node Tiger Salamander Catabolite Activator Protein Sinoatrial Node Cell Rabbit Sinoatrial Node Cell
Unable to display preview. Download preview PDF.
- Biel M, Zong X, Distler M, Bosse E, Klugbauer N, Murakami M, Flockerzi V, Hofmann F (1994) Another member of the cyclic nucleotide-gated channels family, expressed in testis, kidney, and heart. Proc Natl Sci USA 91:3505–3509Google Scholar
- Brown HF, Ho WK (1996) The hyperpolarization-activated inward channel and cardiac pacemaker activity. In: Morad M, Ebashi S, Trautwein W, Kurachi Y (eds) Molecular physiology and pharmacology of cardiac ion channels and transporters. Kluwer Academic Publishers, Dordrecht, pp 17–30Google Scholar
- DiFrancesco D (1996) The hyperpolarization actiated (if) current. Autonomic regulation and the control of pacing. In: Morad M, Ebashi S, Trautwein W, Kurachi Y (eds) Molecular physiology and pharmacology of cardiac ion channels and transporters. Kluwer Academic Publishers, Dordrecht, pp 31–37Google Scholar
- DiFrancesco D, Tortora P (1991) Direct activation of cardiac pacemaker channels by intracellular AMP. Nature 351:145–147Google Scholar
- Ludwig A, Zong X, Jeglitsch M, Hofmann F, Biel M (1998) A family of hyperpolarization-activated mammalian cation channels. 393:587–591Google Scholar
- McCormick DA, Pape HC (1990) Properties of a hyperpolarization-activated cation current and its role in rhythmic oscillation in thalamic relay neurons. J Physiol 432:291–318Google Scholar
- Pfeifer A, Dostmann WRG, Sausbier M, Klatt P, Ruth P, Hofmann F. cGMP-dependent protein kinases: structure and function. Rev Physiol Biochem Pharmacol (in press)Google Scholar
- Pongs O (1996) Diversity of voltage-dependent K channels. In: Morad M, Ebashi S, Trautwein W, Kurachi Y (eds) Molecular physiology and pharmacology of cardiac ion channels and transporters. Kluwer Academic Publishers, Dordrecht, pp 107–117Google Scholar
- Santoro B, Grant SGN, Bartsch D, Kandel ER (1997) Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to Eag and cyclic nucleotide-gated channels. Proc Natl Acad Sci 94:12815–14820Google Scholar