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Factors influencing renal sodium reabsorption in volume expansion

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Reviews of Physiology, Biochemistry and Pharmacology, Volume 92

Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology ((REVIEWS,volume 92))

Abstract

This review summarizes factors influencing renal sodium reabsorption in volume expansion. The influence of renal blood flow and intrarenal blood flow distribution on renal sodium excretion during extracellular volume expansion is unclear. There is no convincing experimental evidence that an increase in renal blood flow per se or a change in the intrarenal distribution of renal blood flow is responsible for the natriuresis of ECVE. An increase in whole kidney glomerular filtration rate has been ruled out as the primary cause of the increase in sodium excretion following volume expansion, and several studies have shown that ECVE is not associated with a change in the intrarenal distribution of GFR. Several investigators propose that the primary variables regulating sodium transport during ECVE are physical factors in the peritubule circulation. There is much evidence to indicate that acute ECVE decreases sodium reabsorption by the proximal tubule. In animals with chronic ECVE, sodium transport along the loop of Henle is decreased. The role of hormonal factors in mediating the natriuresis of volume expansion is controversial. Although current evidence suggests that neurohumoral factors may be important, a role for other hormones, including “natriuretic hormone”, is still not settled. In addition, there is no convincing experimental evidence to date to indicate that a sodium ion receptor exists in the gut or portal circulation.

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  1. Nephrology Research Laboratories, Departments of Physiology and Biophysics and Medicine, Mayo Clinic and Foundation, 55905, Rochester, Minnesota, USA

    Franklyn G. Knox & John A. Haas

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Knox, F.G., Haas, J.A. (1982). Factors influencing renal sodium reabsorption in volume expansion. In: Reviews of Physiology, Biochemistry and Pharmacology, Volume 92. Reviews of Physiology, Biochemistry and Pharmacology, vol 92. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0030503

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