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Medical applications of electrochemical sensors and techniques

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Electrochemistry II

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 143))

Abstract

Four major areas of electrochemistry related to medical diagnostics have been reviewed. Blood pH and gas measurements as well as ISE's represent relatively mature areas which enjoy widespread commercialization. New approaches should yield devices which have superior performance and which are less expensive to produce. Enzyme electrodes and electrochemical immunoassay are still largely experimental, but the intense level of current research effort coupled with some interesting recent developments should lead to commercial success over the next decade.

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6 References

  1. Davis, J. E., Solsky, R. L., Giering, L., Malhotra, S.: Anal. Chem. 55, 202R (1983)

    Google Scholar 

  2. Czaban, J. D.: ibid. 57, 345A (1985)

    Google Scholar 

  3. Rechnitz, G. A.: Trends in Anal. Chem. 5, 172 (1986)

    Article  Google Scholar 

  4. Koryta, J.: Electrochim. Acta 31, 515 (1986)

    Article  Google Scholar 

  5. Pruden, E. L., Siggaard-Anderson, O., Tietz, N. W.: Blood Gases and pH, in: Textbook of Clinical Chemistry (ed.) Tietz, N. W. p. 1191, Philadelphia, Saunders 1986

    Google Scholar 

  6. For a reasonably recent discussion of some specific modern blood gas instrumentation, see: Winckers, E. K. A., Teunissen, A. J., Van Den Camp, R. A. M., Maas, A. H. J., Veefkind, A. H.: J. Clin. Chem. Clin. Biochem. 16, 175 (1978)

    PubMed  Google Scholar 

  7. For a detailed discussion of the art of sample handling and data acquisition for blood gas measurements, see: National Committee for Clinical Laboratory Standards. Blood gas pre-analytical considerations: specimen collection, calibration, and controls; Proposed Guideline. NCCLS publication C27-P, Villanova, Pennsylvania, NCCLS, 1985

    Google Scholar 

  8. Bates, R. G.: Determination of pH: Theory and Practice, New York, Wiley 1964

    Google Scholar 

  9. Eisenman, G., ed.: Glass Electrodes for Hydrogen and Other Cations-Principles and Practice, New York, Dekker 1967

    Google Scholar 

  10. Westcott, C. C.: pH Measurements, New York, Academic Press 1978

    Google Scholar 

  11. Cobbold, R. S.: Transducers for Biomedical Measurements, p. 349, New York, Wiley 1974

    Google Scholar 

  12. Geddes, L. A., Baker, L. E.: Principles of Applied Biomedical Instrumentation, p. 125, New York, Wiley 1968

    Google Scholar 

  13. Ref. 10, pgs. 361–371

    Google Scholar 

  14. Bergveld, P.: IEEE Trans. Biomed. Eng. BME-17, 70 (1970)

    Google Scholar 

  15. Cheung, P. W., Fleming, D. G., Ko, W. H., Neuman, M. R., eds.: Theory, Design and Biomedical Applications of Solid State Chemical Sensors, West Palm Beach, Florida, CRC Press 1978

    Google Scholar 

  16. Sze, S. M.: Physics of Semiconductor Devices, New York, Wiley, 19812

    Google Scholar 

  17. Caras, S., Janata, J.: Anal. Chem. 52, 1935 (1980)

    Article  Google Scholar 

  18. Van der Spiegel, J., Lauks, I., Chen, P., Babic, D.: Sensors and Actuators 4, 291 (1983)

    Article  Google Scholar 

  19. Sibbald, A., Covington, A. K., Carter, R. F.: Clin. Chem. 30, 135 (1984)

    PubMed  Google Scholar 

  20. Sibbald, A.: Sensors and Actuators 7, 23 (1985)

    Article  Google Scholar 

  21. Bergveld, P.: Biosensors 2, 15 (1986)

    Article  PubMed  Google Scholar 

  22. Pace, S. J., Jensen, M. A.: Proceedings of the 2nd International Meeting on Chemical Sensors, p. 557, Bordeaux, France, July 7–10, 1986

    Google Scholar 

  23. Stow, R. W., Baer, R. F., Randall, B. F.: Arch. Phys. Med. 38, 646 (1957)

    PubMed  Google Scholar 

  24. Severinghaus, J. W., Bradley, A. F.: J. Appl. Physiol. 13, 515 (1958)

    PubMed  Google Scholar 

  25. Ref. 11, p. 399

    Google Scholar 

  26. Van der Schoot, B., Bergveld, P.: Sensors and Actuators 8, 11 (1985)

    Article  Google Scholar 

  27. Giner, J.: Electrochim. Acta 8, 857 (1963)

    Article  Google Scholar 

  28. Smith, P. T., Jordon, J.: Proc. Chem. Soc. 1960, 246 (1960)

    Google Scholar 

  29. Roberts, J. L., Sawyer, D. T.: J. Electroanal. Chem. 9, 1 (1965)

    Article  Google Scholar 

  30. Severinghaus, J. W., Weiskopf, R. B., Nishimura, M., Bradley, A. F.: J. Appl. Physiol. 31, 640, (1971)

    PubMed  Google Scholar 

  31. Albery, W. J., Barron, P.: J. Electroanal. Chem. 138, 79 (1982)

    Article  Google Scholar 

  32. Albery, W. J.: U. S. Patent 4,377,446 (1983)

    Google Scholar 

  33. Price, J. F.: Extended Abstracts of the 169th Meeting of The Electrochemical Society, Boston, Massachusetts, Volume 86-1, p. 168 (1986)

    Google Scholar 

  34. Fatt, I.: Polarographic Oxygen Sensors, Cleveland, Ohio, CRC Press 1976

    Google Scholar 

  35. Hitchman, M. L.: Measurement of Dissolved Oxygen, New York, Wiley 1978

    Google Scholar 

  36. Giquere, P. A., Lauzier, L.: Can. J. Res. Sect. B 23, 76 (1945)

    Google Scholar 

  37. Clark, L. C., Trans. Am. Soc. Artif. Intern. Organs 2, 41 (1956)

    Google Scholar 

  38. Kreuzer, F., Kimmich, H. P., Brezina, M.: Polarographic Determination of Oxygen in Biological Materials in: Medical and Biological Applications of Electrochemical Devices (ed.) Koryta, J. Chapt. 6, New York, Wiley 1980

    Google Scholar 

  39. See Ref. 38, p. 178 for an excellent discussion of catheter sensors

    Google Scholar 

  40. Siu, W., Cobbold, R. W. C.: Med. Biol. Eng. 14, 109 (1976)

    PubMed  Google Scholar 

  41. Kimmich, H. P., Kuypers, M. H., Engles, J. M. L., Maas, H. G. R.: Adv. Exp. Med. Biol. 159, 83 (1983)

    PubMed  Google Scholar 

  42. Koudelka, M.: Sensors and Actuators 9, 249 (1986)

    Article  Google Scholar 

  43. Pace, S. J., Sarzycki, P. O., McKeever, R. T., Pelosi, L.: Digest of Technical Papers, 3rd International Conference on Solid-State Sensors and Actuators, p. 406, Philadelphia, Pennsylvania, June 11–14, 1985

    Google Scholar 

  44. Karagounis, V., Lun, L., Liu, C.-C.: IEEE Trans. Biomed. Eng. BME-33, 108 (1986)

    Google Scholar 

  45. Ref. 38, p. 186

    Google Scholar 

  46. Koryta, J.: Anal. Chim. Acta 183, 1 (1986)

    Article  Google Scholar 

  47. Arnold, M. A., Solsky, R. L.: Anal. Chem. 58, 84R (1986)

    Google Scholar 

  48. Buck, R. P. in: Comprehensive Treatise on Electrochemistry, vol. 8, (ed.) White, R. E. p. 137 New York, Plenum Press 1984

    Google Scholar 

  49. Oggenfuss, P., Morf, W. E., Oesch, U., Amman, D., Pretsch, E., Simon, W.: Anal. Chim. Acta 180, 289 (1986)

    Article  Google Scholar 

  50. Thomas, J. D. R.: ibid. 180, 189 (1986)

    Article  Google Scholar 

  51. Moody, G. J., Thomas, J. D. R.: Ion-Selective Electrode Rev. 6, 209 (1984)

    Google Scholar 

  52. Arnold, M. A., Meyerhoff, M. E.: Anal. Chem. 56, 20R (1984)

    Google Scholar 

  53. Karube, I., Suzuki, S.: Ion-Selective Electrode Rev. 6, 15 (1984)

    Google Scholar 

  54. Havas, J.: Ion-and Molecule-Selective Electrodes in Biological Systems, p. 91–167, Berlin Heidelberg New York, Springer-Verlag 1985

    Google Scholar 

  55. Meyerhoff, M.E., Opdycke, W.N.: Ion-Selective Electrodes, in: Advances in Clinical Chemistry 25, 1–47 New York, Academic Press 1986

    Google Scholar 

  56. Savory, J., Bertholf, R. L., Boyd, J. C., Bruns, D. E., Felder, R. A., Lovell, M., Shipe, J. R., Wills, M. R., Czaban, J. D., Coffey, K., O'Connell, K. M.: Anal. Chim. Acta 180, 99 (1986)

    Article  Google Scholar 

  57. Kessler, M., Hofer, J., Harrison, D. K. (eds.): Ion Measurement in Physiology and Medicine, Berlin Heidelberg New York, Springer-Verlag 1985

    Google Scholar 

  58. Simon, W., Ammann, D., Anker, U., Oesch, U., Band, D. M.: Ann. N.Y. Acad. Sci. 428, 279 (1984)

    PubMed  Google Scholar 

  59. Purdy, W. C.: Chem. Int. 4, 13 (1984)

    Google Scholar 

  60. Ladenson, J. H.: Anal. Proc. 20, 554 (1983)

    Google Scholar 

  61. Oggenfuss, P., Morf, W. E., Oesch, U., Ammann, D., Pretsch, E.: Anal. Chim. Acta 180, 299 (1986)

    Article  Google Scholar 

  62. Koryta, J.: Ion-Selective Electrodes, Cambridge, Cambridge University Press 1975

    Google Scholar 

  63. Moody, G. J., Thomas, J. D. R.: Ion-Selective Electrode Rev. 1, 3 (1979)

    Google Scholar 

  64. Stefanac, Z., Simon, W.: Chimia 20, 436 (1966)

    Google Scholar 

  65. Stefanac, Z., Simon, W.: Microchem. J. 12, 125 (1967)

    Article  Google Scholar 

  66. Ref. 9, page 241

    Google Scholar 

  67. Anal. Chem. Lab Guide 58, 88 (1986)

    Google Scholar 

  68. Fogt, E. J.: U.S. Patent 4,565,665 (1986)

    Google Scholar 

  69. Nikolskii, B. P., Materova, E. A.: Ion-Selective Electrode Rev. 7, 3 (1985)

    Google Scholar 

  70. Cattrall, R. W., Freiser, H.: Anal. Chem. 43, 1905 (1971)

    Article  Google Scholar 

  71. Fjeldly, T. A., Nagy, K.: Sensors and Actuators 8, 261 (1985)

    Article  Google Scholar 

  72. Janata, J.: ibid. 4, 255 (1983)

    Article  Google Scholar 

  73. Meyerhoff, M.: Anal. Chem. 57, 1995 (1985)

    Article  PubMed  Google Scholar 

  74. Schulthess, P., Shijo, Y., Pham, H. V., Pretsch, E., Ammann, D., Simon, W.: Anal. Chim. Acta 131, 111 (1981)

    Article  Google Scholar 

  75. Steiner, R. A., Oehme, M., Ammann, D., Simon, W.: Anal. Chem. 51, 351 (1979)

    Article  Google Scholar 

  76. Oehme, M., Simon, W.: Anal. Chim. Acta 86, 21 (1976)

    Article  Google Scholar 

  77. Oehme, M., Kessler, M., Simon, W.: Chimia 30, 204 (1976)

    Google Scholar 

  78. Metzger, E., Ammann, D., Asper, R., Simon, W.: Anal. Chem. 58, 132 (1985)

    Article  Google Scholar 

  79. Scholer, R. P., Simon, W.: Chimia 24, 372 (1970)

    Google Scholar 

  80. Scott, W. J., Chapoteau, E., Kumar, A.: Clin. Chem. 32, 137 (1986)

    PubMed  Google Scholar 

  81. Cooke, R. J., Jensen, R. L.: ibid. 29, 867 (1983)

    PubMed  Google Scholar 

  82. Meyerhoff, M. E.: Anal. Chem. 52, 1532 (1980)

    Article  Google Scholar 

  83. Arnold, M. A., Meyerhoff, M. E.: ibid. 56, 20R (1984)

    Google Scholar 

  84. Carr, P. W., Bowers, L. D.: Immobilized Enzymes in Analytical and Clinical Chemistry, New York, Wiley Interscience Press 1980

    Google Scholar 

  85. Chibata, I.: Immobilized Enzymes, Research and Development, New York, John Wiley & Sons 1978

    Google Scholar 

  86. Guilbault, G.: Analytical Uses of Immobilized Enzymes, New York, Marcel Dekker 1984

    Google Scholar 

  87. Horby, W. E., Morris, D. L.: Immobilized Enzymes, Antigens, Antibodies and Peptides (ed.) Weetall, H. H., New York, Marcel Dekker 1975

    Google Scholar 

  88. Mascini, M., Iannello, M., Palleschi, G.: Anal. Chim. Acta 146, 135 (1983)

    Article  Google Scholar 

  89. Campanella, L., Tomassetti, M., Rapuoli, B., Bruni, M. R.: Am. Clin. Prod. Rev. June, 42 (1986)

    Google Scholar 

  90. Bardeletti, G., Coulet, P. R.: Anal. Chem. 56, 591 (1984)

    Article  PubMed  Google Scholar 

  91. Masoom, M., Townshend, A.: Anal. Chim. Acta 166, 111 (1984)

    Article  Google Scholar 

  92. Yao, T., Sato, M., Kobayashi, Y., Wasa, T.: ibid. 165, 291 (1984)

    Article  Google Scholar 

  93. Watson, B., Stifel, D. N., Semersky, F. E.: ibid. 106, 233 (1979)

    Article  Google Scholar 

  94. Lubrano, G. L., Guilbault, G. G.: ibid. 97, 229 (1978)

    Article  Google Scholar 

  95. Mullen, W. H., Churchouse, S. J., Vadgama, P. M.: Analyst 110, 925 (1985)

    Article  PubMed  Google Scholar 

  96. Hicks, G. P., Updike, S. K.: Anal. Chem. 38, 726 (1966)

    Article  PubMed  Google Scholar 

  97. Lange, M. A., Chambers, J. Q.: Anal. Chim. Acta 175, 89 (1985)

    Article  Google Scholar 

  98. Bourdillon, C., Bourgeois, J. P., Thomas, D.: J. Am. Chem. Soc. 102, 4231 (1980)

    Article  Google Scholar 

  99. Jonsson, G., Gorton, L.: Biosensors 1, 355 (1985)

    Article  PubMed  Google Scholar 

  100. Ianniello, R. M., Lindsay, T. J., Yacynych, A. M. 4: Anal. Chim. Acta 141, 23 (1982)

    Article  Google Scholar 

  101. Wieck, H. J., Heider, G. H., Yacynych, A. M.: ibid. 158, 137 (1984)

    Article  Google Scholar 

  102. Ikeda, T., Katasho, I., Senda, M.: Anal. Sci. 1, 455 (1985)

    Google Scholar 

  103. Yao, T.: Anal. Chim. Acta 153, 175 (1983)

    Article  Google Scholar 

  104. Foulds, N. C., Lowe, C. R.: J. Chem. Soc., Faraday Trans. 1, 82, 1259 (1986)

    Google Scholar 

  105. Gorton, L., Johansson, G.: J. Electroanal. Chem. 113, 151 (1980)

    Article  Google Scholar 

  106. Dixon, M.: Biochim. Biophys. Acta 226, 269 (1971)

    PubMed  Google Scholar 

  107. Clark, L. C., Lyons, L.: Ann. New York Acad. Sci. 102, 29 (1962)

    Google Scholar 

  108. Updike, S., Shults, M. C., Busby, M.: J. Lab. Clin. Med. 93, 518 (1979)

    PubMed  Google Scholar 

  109. Havas, J., Porjesz, E., Nagy, G., Pungor, E.: Hung. Sci. Inst. 49, 53 (1980)

    Google Scholar 

  110. Romette, J.-L., Froment, B., Thomas, D.: Clin. Chim. Acta 95, 249 (1979)

    Article  PubMed  Google Scholar 

  111. Sokol, L., Garber, C., Shults, M., Updike, S.: Clin. Chem. 26, 89 (1980)

    PubMed  Google Scholar 

  112. Gough, D. A., Lucisano, J. Y., Tse, P. H. S.: Anal. Chem. 57, 2351 (1985)

    Article  PubMed  Google Scholar 

  113. Mascini, M., Palleschi, G.: Anal. Chim. Acta 145, 213 (1983)

    Article  Google Scholar 

  114. Taylor, P. J., Kmetec, E., Johnson, J. M.: Anal. Chem. 49, 789 (1977)

    Article  PubMed  Google Scholar 

  115. Tsuchida, T., Yoda, K.: Enzyme Microb. Technol. 3, 326 (1981)

    Article  Google Scholar 

  116. Tsuchida, T., Yoda, K.: Clin. Chem. 29, 51 (1983)

    PubMed  Google Scholar 

  117. Mullen, W. H., Keedy, F. H., Churchouse, S. J., Vadgama, P. M.: Anal. Chim. Acta 183, 59 (1986)

    Article  Google Scholar 

  118. Gorton, L.: ibid. 178, 247 (1985)

    Article  Google Scholar 

  119. Nagy, G., Von Storp, L. H., Guilbault, G. G.: ibid. 66, 443 (1973)

    Article  PubMed  Google Scholar 

  120. Llenado, R. A., Rechnitz, G. A.: Anal. Chem. 45, 826, 2165 (1973)

    Article  PubMed  Google Scholar 

  121. Kulys, J. J., Pesliakiene, M. V., Samalius, A.: Bioelectrochem. Bioenerg. 8, 81 (1981)

    Article  Google Scholar 

  122. Yao, T., Sato, M., Kobayaski, Y., Wasa, T.: Anal. Chim. Acta 165, 291 (1984)

    Article  Google Scholar 

  123. Siddiqi, I. W.: Clin. Chem. 28, 1962 (1982)

    PubMed  Google Scholar 

  124. Lobel, E., Rishpon, J.: Anal. Chem. 53, 51 (1981)

    PubMed  Google Scholar 

  125. Kondo, T., Ito, K., Ohkura, K., Ito, K., Ikeda, S.: Diabetes Care 5, 218 (1982)

    PubMed  Google Scholar 

  126. Murray, R. W.: Chemically Modified Electrodes. Electroanalytical Chemistry 13 (ed.) Bard, A. J., p. 411, New York, Marcel Dekker 1984

    Google Scholar 

  127. Cass, A. E. G., Davis, G., Grancis, G. D., Hill, H. A. O., Aston, W. J., Higgins, I. J., Plotkin, E. V., Scott, L. D. L., Turner, A. P. F.: Anal. Chem. 56, 667 (1984)

    PubMed  Google Scholar 

  128. Turner, A. P. F., Pickup, J. C.: Biosensors 1, 85 (1985)

    Article  PubMed  Google Scholar 

  129. Lange, M. A., Chambers, J. Q.: Anal. Chim. Acta 175, 89 (1985)

    Article  Google Scholar 

  130. Claremont, D. J., Penton, C., Pickup, J. C.: J. Biomed. Eng. 8, 327 (1986)

    Google Scholar 

  131. Crumbliss, A. L., Hill, H. A. O., Page, D. J.: J. Electroanal. Chem. 206, 327 (1986)

    Article  Google Scholar 

  132. Satoh, I., Karube, I., Suzuki, S.: Biotech. Bioeng. 19, 1905 (1977)

    Article  Google Scholar 

  133. Bertrand, C., Conlet, P. R., Gautheron, D. C.: Anal. Chim. Acta 126, 307 (1981)

    Article  Google Scholar 

  134. Bertrand, C., Conlet, P. R., Gautheron, D.: Anal. Lett. 12, 1477 (1979)

    Google Scholar 

  135. Wollenberger, U., Kuhn, M., Scheller, F., Deppmeyer, V., Janchen, M.: Bioelectrochem. Bioenerg. 11, 307 (1983)

    Article  Google Scholar 

  136. Green, M. J., Hill, H. A. O.: J. Chem. Soc., Faraday Trans. 1, 81, 1237 (1986)

    Google Scholar 

  137. Johnson, J. M., Halsall, H. B., Heineman, W. R.: Anal. Chem. 54, 1394 (1982)

    Article  Google Scholar 

  138. Nanjo, M., Guilbault, G. G.: Anal. Chim. Acta 75, 169 (1975)

    Article  PubMed  Google Scholar 

  139. Janchen, M., Grunig, G., Bertermann, K.: Anal. Lett. 18, 1799 (1985)

    Google Scholar 

  140. Schindler, J. G., Gulich, M. V.: Fresenuis Z. Anal. Chem. 308, 434 (1981)

    Article  Google Scholar 

  141. Mizutani, F., Sasaki, K., Shimura, Y.: Anal. Chem. 55, 35 (1983)

    Google Scholar 

  142. Clark, L. C., Noyes, L. K., Grooms, T. A., Gleason, C. A.: Clin. Biochem. 17, 288 (1984)

    Article  PubMed  Google Scholar 

  143. Mascini, M., Moscone, D., Palleschi, G.: Anal. Chim. Acta 157, 45 (1984)

    Article  Google Scholar 

  144. Mizutani, F., Tsuda, K., Karube, I., Suzuki, S., Matsumato, K.: ibid. 118, 65 (1980)

    Article  Google Scholar 

  145. Tsuchida, T., Yoda, K.: Clin. Chem. 29, 51 (1983)

    PubMed  Google Scholar 

  146. Greibee, R. J., Knoblock, E. C., Koch, T. R.: ibid. 27, 163 (1981)

    PubMed  Google Scholar 

  147. Nanjo, M., Guilbault, G. G.: Anal. Chim. Acta 75, 169 (1975)

    Article  PubMed  Google Scholar 

  148. Lubrano, G. J., Guilbault, G. G.: ibid. 97, 229 (1978)

    Article  Google Scholar 

  149. Blaedel, W. J., Jenkins, R. A.: Anal. Chem. 47, 1337 (1975)

    Article  PubMed  Google Scholar 

  150. Moiroux, J., Elving, P. J.: ibid. 50, 1056 (1978)

    Article  Google Scholar 

  151. Moiroux, J., Elving, P. J.: J. Am. Chem. Soc. 102, 6533 (1980)

    Article  Google Scholar 

  152. Jaegfeldt, H.: J. Electroanal. Chem. 110, 295 (1980)

    Article  Google Scholar 

  153. Carlson, B. W., Miller, L. L., Neta, P., Grodkowski, J.: J. Am. Chem. Soc. 106, 7233 (1984)

    Article  Google Scholar 

  154. Blankespoor, R. L., Miller, L. L.: J. Electroanal. Chem. 171, 231 (1984)

    Article  Google Scholar 

  155. Blaedel, W. J., Engstrom, R. C.: Anal. Chem. 52, 1691 (1980)

    Article  Google Scholar 

  156. Yao, T., Kobayashi, Y., Musha, S.: Anal. Chim. Acta 139, 363 (1982)

    Article  Google Scholar 

  157. Cenas, N., Rozgaile, J., Kulys, J.: Biotech. Bioeng. 26, 552 (1984)

    Google Scholar 

  158. Wallace, T. C., Coughlin, R. W.: Anal. Biochem. 80, 133 (1977)

    Article  PubMed  Google Scholar 

  159. Bartalits, L., Nagy, G., Pungor, E.: Anal. Lett. 17, 13 (1984)

    Google Scholar 

  160. Luval, J.-M., Bourdillon, C., Moiroux, J.: J. Am. Chem. Soc. 106, 4701 (1984)

    Article  Google Scholar 

  161. Bartalits, L., Nagy, G., Pungor, E.: Clin. Chem. 30, 1780 (1984)

    PubMed  Google Scholar 

  162. Yao, T., Musha, S.: Anal. Chim. Acta 160, 141 (1984)

    Article  Google Scholar 

  163. Suaud-Chagny, M. R., Gonon, F. G.: Anal. Chem. 58, 413 (1986)

    Article  Google Scholar 

  164. Pan, C. P., Rechnitz, G. A.: Anal. Chim. Acta 160, 141 (1984)

    Article  Google Scholar 

  165. Cheng, F., Christian, G.: Anal. Chem. 49, 1785 (1977)

    Article  PubMed  Google Scholar 

  166. Cheng, F., Christian, G. D.: Clin. Chem. 24, 621 (1978)

    PubMed  Google Scholar 

  167. Cheng, F., Christian, G.: Clin. Chim. Acta 91, 2951 (1979)

    Article  Google Scholar 

  168. Kelley, T. A., Christian, G. D.: Analyst 109, 453 (1984)

    Article  PubMed  Google Scholar 

  169. Williams, D. L., Doig, A. R., Korosi, A.: Anal. Chem. 42, 118 (1970)

    Article  PubMed  Google Scholar 

  170. Attiyat, A. S., Christian, G. D.: Anal. Chim. Acta 106, 225 (1979)

    Article  Google Scholar 

  171. Smith, M. D., Olson, C. L.: Anal. Chem. 46, 1544 (1974)

    Article  PubMed  Google Scholar 

  172. Winartasaputra, H., Kuan, S. S., Guibault, G. G.: ibid. 54, 1987 (1982)

    Article  PubMed  Google Scholar 

  173. Tse, D. C.-S., Kuwana, T.: ibid. 50, 1315 (1978)

    Article  Google Scholar 

  174. Jaegfeldt, H., Torstensson, A. B. C., Johansson, G.: ibid. 53, 1979 (1981)

    Article  Google Scholar 

  175. Jaegfeldt, H., Kuwana, T., Johansson, G.: J. Am. Chem. Soc. 105, 1805 (1983)

    Article  Google Scholar 

  176. Degrand, C., Miller, L. L.: ibid. 102, 5731 (1980)

    Article  Google Scholar 

  177. Huck, H., Schmidt, H.-L.: Angew. Chem. 20, 402 (1981)

    Article  Google Scholar 

  178. Huck, H., Schelter-Graf, A., Danzer, J., Kirch, P., Schmidt, H.-L.: Analyst 109, 147 (1984)

    Article  Google Scholar 

  179. Torstensson, A., Gorton, L.: J. Electroanal. Chem. 130, 293 (1981)

    Article  Google Scholar 

  180. Gorton, L., Torstensson, A., Jaegfeldt, H., Johansson, G.: ibid. 161, 103 (1984)

    Article  Google Scholar 

  181. Appelquist, R., Marko-Varga, G., Gorton, L., Torstensson, A., Johansson, G.: Anal. Chim. Acta 169, 237 (1985)

    Article  Google Scholar 

  182. Huck, H.: Fresnius Z. Anal. Chem. 313, 547 (1982)

    Google Scholar 

  183. Gorton, L., Johansson, G., Torstensson, A.: J. Electroanal. Chem. 196, 81 (1985)

    Article  Google Scholar 

  184. Kulys, J. J.: Enzyme Microb. Technol. 3, 344 (1981)

    Article  Google Scholar 

  185. Albery, W. J., Bartlett, P. N.: J. Chem. Soc. Chem. Commun. 234 (1984)

    Google Scholar 

  186. Kulys, J. J.: Biosensors 2, 3 (1986)

    Article  PubMed  Google Scholar 

  187. Duine, J. A., Frank, J.: Trends in Biochem. Sci. 6, 278 (1981)

    Article  Google Scholar 

  188. Mullen, W. H., Churchouse, S. J., Vadgama, P. M.: Analyst 110, 925 (1985)

    Article  PubMed  Google Scholar 

  189. Turner, A. P. F., Pickup, J. C.: Biosensors 1, 85 (1985)

    Article  PubMed  Google Scholar 

  190. Nilsson, H., Akerlund, A., Mosbach, K.: Biochim. Biophys. Acta 320, 529 (1973)

    PubMed  Google Scholar 

  191. Ruzicka, J., Hansen, E. H., Ghose, A. K., Mottola, H. A.: Anal. Chem. 51, 199 (1979)

    Article  PubMed  Google Scholar 

  192. Vadgama, P. M., Alberti, K. G. M. M., Covington, A. K.: Anal. Chim. Acta 136, 403 (1982)

    Article  Google Scholar 

  193. Alexander, P. W., Joseph, J. P.: ibid. 131, 103 (1981)

    Article  Google Scholar 

  194. Kulys, J. J., Gureviciene, V. V., Laurinavicius, V. A., Jonuska, A. V.: Biosensors 2, 35 (1986)

    Article  PubMed  Google Scholar 

  195. Kirstein, D., Kirstein, L., Scheller, F.: ibid. 1, 117 (1985)

    Article  PubMed  Google Scholar 

  196. Guibault, G. G., Montalvo, J. G.: J. Am. Chem. Soc. 91, 2164 (1969)

    Article  PubMed  Google Scholar 

  197. Guilbault, G. G., Nagy, G.: Anal. Chem. 45, 417 (1973)

    Article  Google Scholar 

  198. Thanei-Wyss, U., Morf, W. E., Leinemann, P., Stefanac, Z., Mostert, I., Dorig, R., Dohner, R. E., Simon, W.: Mikrochim. Acta 3, 135 (1983)

    Article  Google Scholar 

  199. Yasuda, K., Miyagi, H., Hamada, Y., Tokata, Y.: Analyst 109, 61 (1984)

    Article  PubMed  Google Scholar 

  200. Anfalt, T., Granelli, A., Jagner, D.: Anal. Lett. 6, 969 (1973)

    Google Scholar 

  201. Johansson, G., Ogren, L.: Anal. Chim. Acta 84, 23 (1976)

    Article  PubMed  Google Scholar 

  202. Papastathopoulas, D. S., Rechnitz, G. A.: ibid. 79, 17 (1975)

    Article  PubMed  Google Scholar 

  203. Mascini, M., Guilbault, G. G.: Anal. Chem. 49, 795 (1977)

    Article  PubMed  Google Scholar 

  204. Guilbault, G. G., Shu, F.: ibid. 44, 2161 (1972)

    Article  PubMed  Google Scholar 

  205. Winquist, F., Spatz, A., Lundstrom, I., Danielsson, B.: Anal. Chim. Acta 164, 124 (1984)

    Article  Google Scholar 

  206. Thompson, H., Rechnitz, G. A.: Anal. Chem. 46, 246 (1974)

    Article  PubMed  Google Scholar 

  207. Guilbault, G. G., Chen, S. P., Kuan, S. S.: Anal. Lett. 13, 1607 (1980)

    Google Scholar 

  208. Mascini, M., Palleschi, G.: Anal. Chim. Acta 136, 69 (1982)

    Article  Google Scholar 

  209. Mascini, M., Fortunati, S., Moscone, D., Palleschi, G.: ibid. 171, 175 (1985)

    Article  Google Scholar 

  210. Winquist, F., Lundstrom, I., Danielsson, B.: Anal. Chem. 58, 145 (1986)

    Article  PubMed  Google Scholar 

  211. Havas, J., Guilbault, G. G.: ibid. 54, 1991 (1982)

    Article  Google Scholar 

  212. Tran, N. D., Romette, J. L., Thomas, D.: Biotech. Bioeng. 25, 329 (1983)

    Article  Google Scholar 

  213. Bradley, C. R., Rechnitz, G. A.: Anal. Chem. 56, 664 (1984)

    Google Scholar 

  214. Heineman, W. R., Halsall, H. B.: ibid. 57, 1321A (1985)

    Google Scholar 

  215. Del Castillo, J., Rodriguez, A., Romero, C. A., Sanchez, V.: Science 153, 185 (1966)

    PubMed  Google Scholar 

  216. Barfort, P., Arquilla, E. R., Vogelhut, P. O.: ibid. 160, 1119 (1968)

    PubMed  Google Scholar 

  217. Janata, J.: J. Am. Chem. Soc. 97, 2914 (1975)

    Article  Google Scholar 

  218. Aizawa, M., Kato, S., Suzuki, S.: J. Membr. Sci. 2, 125 (1977)

    Article  Google Scholar 

  219. Aizawa, M., Suzuki, S., Nagamura, Y., Shinohara, R., Ishiguro, I.: Chem. Lett. 1977, 779 (1977)

    Google Scholar 

  220. Meyerhoff, M., Rechnitz, G. A.: Science 195, 494 (1977)

    PubMed  Google Scholar 

  221. Aizawa, M., Suzuki, S.: J. Solid-Phase Biochem. 4, 25 (1979)

    Google Scholar 

  222. Yamamoto, N., Nagasawa, Y., Shuto, S., Sawai, M., Sudo, T., Tsubomura, H.: Chem. Lett. 1978, 245 (1978)

    Google Scholar 

  223. Yamamoto, N., Nagasawa, Y., Sawai, M., Sudo, T., Tsubomura, H.: J. Immunol. Methods 22, 309 (1978)

    Article  PubMed  Google Scholar 

  224. Yamamoto, N., Nagasawa, Y., Shuto, S., Tsubomura, H., Sawai, M., Okumura, H.: Clin. Chem. 26, 1569 (1980)

    PubMed  Google Scholar 

  225. Malmros, M. K.: U. S. Patent #4,334,880 (1980)

    Google Scholar 

  226. Collins, S., Janata, J.: Anal. Chim. Acta. 136, 93 (1982)

    Article  Google Scholar 

  227. Janata, J., Blackburn, G. F.: Ann. N.Y. Acad. Sci. 428, 286 (1984)

    PubMed  Google Scholar 

  228. Solski, R. L., Rechnitz, G. A.: Science 204, 1308 (1979)

    PubMed  Google Scholar 

  229. Solski, R. L., Rechnitz, G. A.: Anal. Chim. Acta 123, 135 (1981)

    Article  Google Scholar 

  230. Solski, R. L., Rechnitz, G. A.: U. S. Patent #4,402,819 (1983)

    Google Scholar 

  231. Keating, M. Y., Rechnitz, G. A.: Anal. Chem. 56, 801 (1984)

    PubMed  Google Scholar 

  232. Monroe, D.: ibid. 56, 921A (1984)

    Google Scholar 

  233. Cardosi, M. F., Stanley, C. J., Turner, A. P. F.: Proceedings of the 2nd International Meeting on Chemical Sensors, p. 634, Bordeaux, France, July 7–10, 1986

    Google Scholar 

  234. Breyer, B., Radcliff, F. J.: Nature 167, 79 (1951)

    Google Scholar 

  235. Breyer, B., Radcliff, F. J.: Aust. J. Exp. Biol. 31, 167 (1953)

    Google Scholar 

  236. Alexander, P. W., Rechnitz, G. A.: Anal. Chem. 46, 1253 (1974)

    Article  PubMed  Google Scholar 

  237. Solsky, R. L., Rechnitz, G. A.: Anal. Chim. Acta 99, 241 (1978)

    Article  Google Scholar 

  238. Boitieux, J.-L., Desmet, G., Thomas, D.: Clin. Chem. 25, 318 (1979)

    PubMed  Google Scholar 

  239. Meyerhoff, M. E., Rechnitz, G. A.: Anal. Biochem. 95, 483 (1979)

    Article  PubMed  Google Scholar 

  240. Alexander, P. W., Maltra, C.: Anal. Chem. 54, 68 (1982)

    PubMed  Google Scholar 

  241. Aizawa, M., Morioka, A., Matsuoka, H., Suzuki, S., Nagamura, Y., Shinohara, R., Ishiguro, I.: J. Solid-Phase Biochem. 1, 319 (1976)

    Google Scholar 

  242. Aizawa, M., Morioka, A., Suzuki, S.: Anal. Chim. Acta 115, 61 (1980)

    Article  Google Scholar 

  243. Itagaki, H., Hakoda, Y., Suzuki, Y., Haga, M.: Chem. Pharm. Bull. 31, 1283 (1983)

    Google Scholar 

  244. Karube, I., Matsunaga, T., Suzuki, S., Asano, T., Itoh, S.: J. Biotechnology 1, 279 (1984)

    Article  Google Scholar 

  245. Ikariyama, Y., Furuki, Aizawa, M.: Anal. Chem. 57, 496 (1985)

    Article  PubMed  Google Scholar 

  246. Yuan, C.-L., Kuan, S. S., Guilbault, G. G.: ibid. 53, 1906 (1981)

    Google Scholar 

  247. Robinson, G. A., Cole, V. M., Rattle, S. J., Forrest, G. C.: Biosensors 2, 45 (1986)

    Article  PubMed  Google Scholar 

  248. Weber, S. G., Purdy, W. C.: Anal. Lett. 12, 1 (1979)

    Google Scholar 

  249. Di Gleria, K., Hill, H. A. O., McNeil, C. J., Green, M.: Anal. Chem. 58, 1203 (1986)

    Article  PubMed  Google Scholar 

  250. Wehmeyer, K. R., Halsall, H. B., Heineman, W. R.: Clin. Chem. 28, 1968 (1982)

    PubMed  Google Scholar 

  251. Heineman, W. R., Anderson, C. W., Halsall, H. B.: Science 204, 865 (1979)

    PubMed  Google Scholar 

  252. D'Orazio, P., Rechnitz, G. A.: Anal. Chim. Acta 109, 25 (1979)

    Article  Google Scholar 

  253. Gebauer, C. R., Rechnitz, G. A.: Anal. Biochem. 103, 280 (1980)

    Article  PubMed  Google Scholar 

  254. Shiba, K., Watanabe, T., Umezawa, Y., Fujiwara, S.: Chem. Lett. 155 (1980)

    Google Scholar 

  255. Shiba, K., Umezawa, Y., Watanabe, T., Ogawa, S., Fujiwara, S.: Anal. Chem. 52, 1610 (1980)

    Article  PubMed  Google Scholar 

  256. Haga, M., Itagaki, H., Sugawara, S., Okano, T.: Biochem. Biophys. Res. Comm. 95, 187 (1980)

    Article  PubMed  Google Scholar 

  257. Brontman, S. B., Meyerhoff, M. E.: Anal. Chim. Acta 162, 363 (1984)

    Article  Google Scholar 

  258. Gebauer, C. R., Rechnitz, G. A.: Anal. Biochem. 124, 338 (1982)

    Article  PubMed  Google Scholar 

  259. Eggers, H. M., Halsall, H. B., Heineman, W. R.: Clin. Chem. 28, 1848 (1982)

    PubMed  Google Scholar 

  260. Broyles, C. A., Rechnitz, G. A.: Anal. Chem. 58, 1241 (1986)

    Article  PubMed  Google Scholar 

  261. Fonong, T., Rechnitz, G. A.: ibid. 56, 2586 (1984)

    Article  PubMed  Google Scholar 

  262. Ngo, T. T., Bovaird, J. H., Lenhoff, H. M.: Appl. Biochem. Biotech. 11, 63 (1985)

    Google Scholar 

  263. Oberhardt, B. J., Wotherspoon, N.: U. S. Patent 4,280,815 (1981)

    Google Scholar 

  264. Olsson, T., Thore, A.: Chemiluminescence and Its Use in Immunoassay in: Immunoassays for the 80's (eds.) Voller, A., Bartlett, A., Bidwell, D. p. 113, Baltimore, Maryland, University Park Press 1981 the 80's (eds. Voller, A., Bartlett, A., Bidwell, D.) p. 113, New York, MTP Press 1981

    Google Scholar 

  265. Ikariyama, Y., Kunoh, H., Aizawa, M.: Biochem. Biophys. Res. Comm. 128, 987 (1985)

    PubMed  Google Scholar 

  266. Ege, D., Becker, W. G., Bard, A. J.: Anal. Chem. 56, 2413 (1984)

    Article  PubMed  Google Scholar 

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    Gary S. Calabrese & Kathleen M. O'Connell

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Calabrese, G.S., O'Connell, K.M. (1988). Medical applications of electrochemical sensors and techniques. In: Steckhan, E. (eds) Electrochemistry II. Topics in Current Chemistry, vol 143. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0018071

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