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Differential inhibitory effects of humic acids on coagulation systems of human blood

  • Session 4: Biological Activity
  • Conference paper
  • First Online:
Humic Substances in the Aquatic and Terrestrial Environment

Part of the book series: Lecture Notes in Earth Sciences ((LNEARTH,volume 33))

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Abstract

The present study demonstrated a strong inhibition of the intrinsic pathway of blood coagulation, when 10 µg of humic acid was added to 0.1 ml citrated plasma. An effect on the extrinsic coagulation system was only obtained after addition of more than 30 µg per 0.1 ml plasma, and was confined to a slight increase in the coagulation time. During determination of the thrombin time, humic acid, at concentrations above 40 µg per 0.1 ml plasma, acted like an antithrombin, by means of a sudden inactivation of thrombin. The humic acids were characterized by infrared spectroscopy. Humic acids were purified using a dialyzer as applied for urea clearance in nephrological therapy. The application of this method is novel.

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Authors and Affiliations

  1. Institut für Bodenwissenschaften, Universität Göttingen, D-3400, Göttingen, Germany

    Helga Kübler

Authors
  1. Helga Kübler
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Editor information

Bert Allard Hans Borén Anders Grimvall

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© 1991 Springer-Verlag

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Kübler, H. (1991). Differential inhibitory effects of humic acids on coagulation systems of human blood. In: Allard, B., Borén, H., Grimvall, A. (eds) Humic Substances in the Aquatic and Terrestrial Environment. Lecture Notes in Earth Sciences, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0010494

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  • DOI: https://doi.org/10.1007/BFb0010494

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53702-1

  • Online ISBN: 978-3-540-46985-8

  • eBook Packages: Springer Book Archive

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