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Bioproducts pp 95-130 | Cite as

Applications of stereoselectivity of enzymes: Synthesis of optically active amino acids and α-hydroxy acids, and stereospecific isotope-labeling of amino acids, amines and coenzymes

  • Kazuo Yonaha
  • Kenji Soda
Conference paper
Part of the Advances in Biochemical Engineering/Biotechnology book series (ABE, volume 33)

Abstract

Various enantiomeric amino acids and α-hydroxy acids are produced by means of highly stereospecific microbial enzymes from optically active, racemic, and achiral starting materials which are produced cheaply by chemical industry. Several enzymes are used for the stereoselective labeling of amino acids, amines, and coenzymes with deuterium or tritium. The mechanisms of these enzyme reactions also are described here.

Keywords

Enzymatic Synthesis Reductive Amination Amino Acid Ester Active Amino Acid Amino Acid Decarboxylase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

PL

pyridoxal

PM

pyridoxamine

PLP

pyridoxal 5′-phosphate

PMP

pyridoxamine 5′-phosphate

NAD

nicotinamide adenine dinucleotide

NADP

nicotinamide adenine dinucleotide phosphate

l-DOPA

3,4-dihydroxy-l-phenylalanine

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • Kazuo Yonaha
    • 1
  • Kenji Soda
    • 2
  1. 1.Department of Agricultural ChemistryUniversity of The Ryukyus NishiharaOkinawaJapan
  2. 2.Institute for Chemical ResearchKyoto UniversityKyotoJapan

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