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Applications of stereoselectivity of enzymes: Synthesis of optically active amino acids and α-hydroxy acids, and stereospecific isotope-labeling of amino acids, amines and coenzymes

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Bioproducts

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 33))

Abstract

Various enantiomeric amino acids and α-hydroxy acids are produced by means of highly stereospecific microbial enzymes from optically active, racemic, and achiral starting materials which are produced cheaply by chemical industry. Several enzymes are used for the stereoselective labeling of amino acids, amines, and coenzymes with deuterium or tritium. The mechanisms of these enzyme reactions also are described here.

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Abbreviations

PL:

pyridoxal

PM:

pyridoxamine

PLP:

pyridoxal 5′-phosphate

PMP:

pyridoxamine 5′-phosphate

NAD:

nicotinamide adenine dinucleotide

NADP:

nicotinamide adenine dinucleotide phosphate

l-DOPA:

3,4-dihydroxy-l-phenylalanine

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Authors and Affiliations

  1. Department of Agricultural Chemistry, University of The Ryukyus Nishihara, 903-01, Okinawa, Japan

    Kazuo Yonaha

  2. Institute for Chemical Research, Kyoto University, Uji, 611, Kyoto, Japan

    Kenji Soda

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  1. Kazuo Yonaha
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  2. Kenji Soda
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Yonaha, K., Soda, K. (1986). Applications of stereoselectivity of enzymes: Synthesis of optically active amino acids and α-hydroxy acids, and stereospecific isotope-labeling of amino acids, amines and coenzymes. In: Bioproducts. Advances in Biochemical Engineering/Biotechnology, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0002454

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