Abstract
The research begins with the studies of fetal abnormalities related Trisomy 21 with maternal and fetal health data. An exploration on current modalities for Trisomy 21 detection methods namely Biochemistry triple tests, Genetic testing, and Ultrasound prenatal screening shall be completed prior to investigation of each of their manual working principle, advantages and drawbacks. With the help of clinician, ultrasound prenatal screening was chosen based on its clinical acceptance, cost, potential of usage and safe imaging. This existing imaging modality is used to formulate a new method for Trisomy 21 early detection due to its current critical limitations. Studied ultrasound markers are decided based on the result from previous researches, where nuchal translucency or NT is found to be most effective marker for Trisomy 21 assessment. Ultrasound fetal images and other related maternal materials will be collected from some sources, i.e. from online library, clinics and hospitals. They will be grouped and analysed, i.e. image history, image structure, noise and image extraction.This chapter includes an introduction, the background, the objective and scope of the book. The main aim is to show the motivation of this research and the existing limitation on ultrasound prenatal scanning protocol for Nuchal translucency. It will also describe its research methodology in brief. This chapter is summarized with the novelties and contribution of book and its feasibility.
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Lai, K.W., Supriyanto, E. (2013). Introduction. In: Detection of Fetal Abnormalities Based on Three Dimensional Nuchal Translucency. SpringerBriefs in Applied Sciences and Technology. Springer, Singapore. https://doi.org/10.1007/978-981-4021-96-8_1
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DOI: https://doi.org/10.1007/978-981-4021-96-8_1
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