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Disulfiram: The History Behind the Molecule

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Disulfiram

Abstract

This chapter provides an overview of the history, genesis and discovery of Disulfiram as a molecule and its emergence into the long-term pharmacotherapy of alcohol dependence. The chapter traces the discovery of the molecule and how it came to be accepted as a treatment for alcohol dependence. The hurdles and difficulties faced in its pharmacological processing and acceptance are also discussed.

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References

  1. Suh JJ, Pettinati HM, Kampman KM, O’brien CP. The status of disulfiram: a half of a century later. J Clin Psychopharmacol. 2006;26(3):290–302.

    Article  PubMed  Google Scholar 

  2. Lundwall L, Baekeland F. Disulfiram treatment of alcoholism—a review. J Nerv Ment Dis. 1971;153(6):381–94.

    Article  PubMed  Google Scholar 

  3. Pal A, Pattanayak RD, Sagar R. Tracing the journey of disulfiram: from an unintended discovery to a treatment option for alcoholism. J Ment Health Hum Behav. 2015;20(1):41–3.

    Article  Google Scholar 

  4. Ellis PM, Dronsfield AT. Antabuse’s diamond anniversary: still sparkling on? Drug Alcohol Rev. 2013;32(4):342–4.

    Article  PubMed  Google Scholar 

  5. Billet SL. Antabuse therapy. Alcoholism: the total treatment approach. Springfield, IL: Charles C. Thomas; 1968.

    Google Scholar 

  6. Holmberg B, Sjöström B. Toxicological aspects of chemical hazards in the rubber industry. J Toxicol Environ Health. 1980;6(5–6):1201–9.

    Article  PubMed  Google Scholar 

  7. Tamai H, Yokoyama A, Okuyama K, Takahashi H, Maruyama K, Suzuki Y, Ishii H. Comparison of cyanamide and disulfiram in effects on liver function. Alcohol Clin Exp Res. 2000;24(4 Suppl):97S–9S.

    Article  PubMed  Google Scholar 

  8. Landegren J, Borglund E, Storgårds K. Treatment of scabies with disulfiram and benzyl benzoate emulsion: a controlled study. Acta Derm Venereol. 1978;59(3):274–6.

    Google Scholar 

  9. Jacobsen E. Deaths of alcoholic patients treated with disulfiram (tetraethylthiuram disulfide) in Denmark. Q J Stud Alcohol. 1952;13(1):16–26.

    PubMed  Google Scholar 

  10. Hald J, Jacobsen E, Larsen V. Formation of acetaldehyde in the organism in relation to dosage of antabuse (tetraethylthiuram-disulphide) and to alcohol-concentration in blood. Basic Clin Pharmacol Toxicol. 1949;5(2):179–88.

    Google Scholar 

  11. Jacobsen E. The pharmacology of antabuse (tetraethylthiuramdisulphide). Addiction. 1950;47(1):26–40.

    Article  Google Scholar 

  12. Jacobsen E, Larsen V. Site of the formation of acetaldehyde after ingestion of antabuse (tetraethylthiuramdisulphide) and alcohol. Basic Clin Pharmacol Toxicol. 1949;5(3):285–91.

    Google Scholar 

  13. Jacobsen E, Martensen-Larsen O. Treatment of alcoholism with tetraethylthiuram disulfide (Antabus®). JAMA. 1949;139(14):918–22.

    Article  Google Scholar 

  14. Jacobsen E. Is acetaldehyde an intermediary product in normal metabolism? Biochim Biophys Acta. 1950;4:330–4.

    Article  PubMed  Google Scholar 

  15. Wright C, Moore RD. Disulfiram treatment of alcoholism. Am J Med. 1990;88(6):647–55.

    Article  PubMed  Google Scholar 

  16. Hald J, Jacobsen E, Larsen V. The sensitizing effect of tetraethylthiuramdisulphide (antabuse) to ethylalcohol. Basic Clin Pharmacol Toxicol. 1948;4(3–4):285–96.

    Google Scholar 

  17. Hald J, Jacobsen E. A drug sensitising the organism to ethyl alcohol. Lancet. 1948;252(6539):1001–4.

    Article  Google Scholar 

  18. Hald J, Jacobsen E, Larsen V. The antabuse effect of some compound. Related to antabuse and cyanamide. Basic Clin Pharmacol Toxicol. 1952;8(4):329–37.

    Google Scholar 

  19. Petersen EN. The pharmacology and toxicology of disulfiram and its metabolites. Acta Psychiatr Scand. 1992;86(S369):7–13.

    Article  Google Scholar 

  20. Glud E. The treatment of alcoholic patients in Denmark with antabuse with suggestions for its trial in the United States. Q J Stud Alcohol. 1949;10(2):185–90.

    PubMed  Google Scholar 

  21. Miller WR, Walters ST, Bennett ME. How effective is alcoholism treatment in the United States? J Stud Alcohol. 2001;62(2):211–20.

    Article  PubMed  Google Scholar 

  22. Asmussen E, Hald J, Jacobsen E, Jørgensen G. Studies on the effect of tetraethylthiuramdisulphide (antabuse) and alcohol on respiration and circulation in normal human subjects. Basic Clin Pharmacol Toxicol. 1948;4(3–4):297–304.

    Google Scholar 

  23. Jacobsen E. The metabolism of ethyl alcohol. Nature. 1952;169(4303):645–7.

    Article  PubMed  Google Scholar 

  24. Vallari RC, Pietruszko R. Human aldehyde dehydrogenase: mechanism of inhibition of disulfiram. Science. 1982;216(4546):637–9.

    Article  PubMed  Google Scholar 

  25. Kjeldgaard NO. Inhibition of aldehyde oxidase from liver by tetraethylthiuramdisulphide (antabuse). Basic Clin Pharmacol Toxicol. 1949;5(4):397–403.

    Google Scholar 

  26. Johansson B. A review of the pharmacokinetics and pharmacodynamics of disulfiram and its metabolites. Acta Psychiatr Scand. 1992;86(S369):15–26.

    Article  Google Scholar 

  27. Kragh H. From disulfiram to antabuse: the invention of a drug. Bull Hist Chem. 2008;33(2):82–8.

    Google Scholar 

  28. Carroll KM, Nich C, Ball SA, McCance E, Rounsavile BJ. Treatment of cocaine and alcohol dependence with psychotherapy and disulfiram. Addiction. 1998;93(5):713–27.

    Article  PubMed  Google Scholar 

  29. Aaes-Jørgensen E, Dam H, Granados H. The influence of antabuse (tetraethylthiuramdisulphide) and methylene blue on certain vitamin E deficiency symptoms and on growth in rats. Basic Clin Pharmacol Toxicol. 1951;7(2):171–80.

    Google Scholar 

  30. Dogterom P, Mulder GJ, Nagelkerke JF. Lipid peroxidation-dependent and -independent protein thiol modifications in isolated rat hepatocytes: differential effects of vitamin E and disulfiram. Chem-Biol Interact. 1989;71(2–3):291–306.

    Article  PubMed  Google Scholar 

  31. Wang W, McLeod HL, Cassidy J. Disulfiram-mediated inhibition of NF-κB activity enhances cytotoxicity of 5-fluorouracil in human colorectal cancer cell lines. Int J Cancer. 2003;104(4):504–11.

    Article  PubMed  Google Scholar 

  32. Sauna ZE, Shukla S, Ambudkar SV. Disulfiram, an old drug with new potential therapeutic uses for human cancers and fungal infections. Mol Biosyst. 2005;1(2):127–34.

    Article  PubMed  Google Scholar 

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De Sousa, A. (2019). Disulfiram: The History Behind the Molecule. In: Disulfiram. Springer, Singapore. https://doi.org/10.1007/978-981-32-9876-7_1

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