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Impact of Microbial Genomics Approaches for Novel Antibiotic Target

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Microbial Genomics in Sustainable Agroecosystems

Abstract

Infectious diseases are life-threatening and may lead to high mortality and morbidity rates. The existing danger of an increase and spread of multidrug resistance pathogens is a global concern. Therefore, the designing of novel antibiotics and vaccine to control and eliminate the disease is an utmost requirement. Traditional approaches for screening vaccine and drug targets are time-consuming and have been unsuccessful in controlling the spread of infectious diseases due to several reasons such as altered antigenic diversity, altered virulence potential, and antimicrobial resistance in the infectious agent population. To overcome this problem, there has been a paradigm shift from the conventional to microbial genomics approaches, as the availability of complete genome sequence of pathogenic microorganisms and multiple isolates of the same species provides a wealth of information on nearly all the potential drug targets. Microbial genomics approaches open up new avenues to pursuit novel antimicrobial agents that are highly conserved in a range of microbes, essential for the survival of pathogens and absent in humans. In this chapter, we present an overview of the microbial genomics approaches such as pan-genomics, comparative genomics, functional genomics, structural genomics, transcriptomics, and proteomics used in the discovery and development of novel antibiotics.

Hemant Joshi and Akanksha Verma are both considered as first author.

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Authors and Affiliations

  1. School of Biotechnology, Jawaharlal Nehru University, New Delhi, India

    Hemant Joshi

  2. Department of Botany, MLKPG College, Balrampur, Uttar Pradesh, India

    Akanksha Verma

  3. Department of Molecular Biology, Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden

    Dharmendra Kumar Soni

  4. Laboratory of Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden

    Dharmendra Kumar Soni

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  1. Hemant Joshi
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  2. Akanksha Verma
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  3. Dharmendra Kumar Soni
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Correspondence to Dharmendra Kumar Soni .

Editor information

Editors and Affiliations

  1. Department of Molecular and Cellular Engineering, Sam Higginbottom University of Agriculture Technology and Sciences, Allahabad, Uttar Pradesh, India

    Vijay Tripathi

  2. Department of Forestry, North Eastern Regional Institute of Science and Technology (NERIST), Nirjuli, Arunachal Pradesh, India

    Pradeep Kumar

  3. Department of Computational Biology and Bioinformatics, Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad, Uttar Pradesh, India

    Pooja Tripathi

  4. Department of Botany, Kamla Nehru P.G. College, Raebareli, Uttar Pradesh, India

    Amit Kishore

  5. Department of Forestry, North Eastern Regional Institute of Science and Technology (NERIST), Nirjuli, Arunachal Pradesh, India

    Madhu Kamle

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Joshi, H., Verma, A., Soni, D.K. (2019). Impact of Microbial Genomics Approaches for Novel Antibiotic Target. In: Tripathi, V., Kumar, P., Tripathi, P., Kishore, A., Kamle, M. (eds) Microbial Genomics in Sustainable Agroecosystems. Springer, Singapore. https://doi.org/10.1007/978-981-32-9860-6_5

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