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Anticancer Immunotherapy: Prospects and Challenges

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Unravelling Cancer Signaling Pathways: A Multidisciplinary Approach

Abstract

Accumulating evidence indicates that immune cells in the microenvironment play a significant role in tumor progression. Understanding the dynamic interplay between tumor cells and the host immune system is therefore of critical importance. While some immunotherapeutic strategies aim to specifically overcome hyporesponsiveness to tumor-associated antigens, others seek to nonspecifically activate the immune system; efficacy and toxicity are overriding, and often conflicting, concerns. This chapter, while occasionally providing brief historical perspectives, describes ongoing efforts in the area, including strategies for anticancer vaccination and adoptive cell transfer, the use of cytokines and development of oncolytic viruses, and the administration of checkpoint inhibitors. While significant successes have been achieved, the field is also characterized by notable failure, an indication that much remains unknown about factors that trigger and promote tumorigenesis, about current limitations in the effective delivery of therapeutic moieties, and about the workings of the immune system.

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Authors and Affiliations

  1. National Institute of Immunology, New Delhi, India

    Ruchi Sachdeva, Poonam Singh, Anjali Bose, Beneeta Kalha, Moumita Sarkar & Rahul Pal

Authors
  1. Ruchi Sachdeva
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  2. Poonam Singh
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  3. Anjali Bose
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  4. Beneeta Kalha
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  5. Moumita Sarkar
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  6. Rahul Pal
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Corresponding author

Correspondence to Rahul Pal .

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Editors and Affiliations

  1. Integrated Biophysics and Structural Biology Lab, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Homi Bhabha National Institute, Navi Mumbai, Maharashtra, India

    Kakoli Bose

  2. Comparative Oncology Program and Small Animal Imaging Facility, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Homi Bhabha National Institute, Navi Mumbai, Maharashtra, India

    Pradip Chaudhari

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Sachdeva, R., Singh, P., Bose, A., Kalha, B., Sarkar, M., Pal, R. (2019). Anticancer Immunotherapy: Prospects and Challenges. In: Bose, K., Chaudhari, P. (eds) Unravelling Cancer Signaling Pathways: A Multidisciplinary Approach. Springer, Singapore. https://doi.org/10.1007/978-981-32-9816-3_8

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