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Applications of Microarray in Cancer Cell Signaling Pathways

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Unravelling Cancer Signaling Pathways: A Multidisciplinary Approach

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Abstract

Microarrays allow for the analysis of transcription in a large number of genes simultaneously. They have played an important role in the identification of cancer cell signaling pathways. The ease of use and reliability of microarrays has been a result of standardization of assay protocols and consolidation of data analysis techniques. Online public repositories of gene expression profile data have been created, allowing for researchers to test their hypothesis regarding the link between gene signaling and disease. Microarrays have many different applications in the study of cancer. It allows for disease stratification of tumors into different molecular subgroups. They can also provide additional information on disease mechanism, cancer prognosis, and cancer metastasis. Multiple studies have used microarrays on cell lines to perform preclinical screening to predict anticancer drug responses. In addition, they can be used in real-life patient’s tissues to provide personalized prediction of drug response.

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  1. Pak Ling Lui and Tae-Hoon Chung have equally contributed to this chapter.

Authors and Affiliations

  1. Department of Haematology-Oncology, National University Cancer Institute, Singapore, National University Health System, Singapore, Singapore

    Pak Ling Lui & Wee Joo Chng

  2. Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

    Tae-Hoon Chung & Wee Joo Chng

  3. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

    Wee Joo Chng

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  1. Pak Ling Lui
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  2. Tae-Hoon Chung
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  3. Wee Joo Chng
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Correspondence to Wee Joo Chng .

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  1. Integrated Biophysics and Structural Biology Lab, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Homi Bhabha National Institute, Navi Mumbai, Maharashtra, India

    Kakoli Bose

  2. Comparative Oncology Program and Small Animal Imaging Facility, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Homi Bhabha National Institute, Navi Mumbai, Maharashtra, India

    Pradip Chaudhari

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Lui, P.L., Chung, TH., Chng, W.J. (2019). Applications of Microarray in Cancer Cell Signaling Pathways. In: Bose, K., Chaudhari, P. (eds) Unravelling Cancer Signaling Pathways: A Multidisciplinary Approach. Springer, Singapore. https://doi.org/10.1007/978-981-32-9816-3_15

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