Role of Co-stimulatory Molecules in T Helper Cell Differentiation

  • Michelle Schorer
  • Vijay K. Kuchroo
  • Nicole JollerEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1189)


CD4+ T cells play a central role in orchestrating the immune response to a variety of pathogens but also regulate autoimmune responses, asthma, allergic responses, as well as tumor immunity. To cover this broad spectrum of responses, naïve CD4+ T cells differentiate into one of several lineages of T helper cells, including Th1, Th2, Th17, and TFH, as defined by their cytokine pattern and function. The fate decision of T helper cell differentiation integrates signals delivered through the T cell receptor, cytokine receptors, and the pattern of co-stimulatory signals received. In this review, we summarize the contribution of co-stimulatory and co-inhibitory receptors to the differentiation and maintenance of T helper cell responses.


Co-stimulatory molecules T cell differentiation Th1 Th2 Th17 TFH 



This work was supported by the Swiss National Science Foundation (PP00P3_150663 and PP00P3_ 181037 to N.J.), the European Research Council (677200 to N.J.), the Zuercher Universitaetsverein (ZUNIV-FAN to N.J.), the Olga Mayenfisch Stiftung (to N.J.), and the Novartis Foundation for medical-biological research (17A027 to N.J.).


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Michelle Schorer
    • 1
  • Vijay K. Kuchroo
    • 2
    • 3
  • Nicole Joller
    • 1
    Email author
  1. 1.Institute for Experimental ImmunologyUniversity of ZurichZurichSwitzerland
  2. 2.Evergrande Center for Immunologic DiseasesHarvard Medical School and Brigham & Women’s HospitalBostonUSA
  3. 3.Klarman Cell ObservatoryBroad Institute of MIT and HarvardCambridgeUSA

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