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Flame Retardants: Exposure, Biomarkers, and Health Risks

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Emerging Chemicals and Human Health

Abstract

Flame retardants have been extensively used in various fields of production and daily life, such as aerospace, transportation, and interior decoration, to ensure fire safety. They are mainly divided into inorganic, halogenated organic, nitrogen-containing, and phosphorus-containing compounds, among which, brominated flame retardants and organophosphorous flame retardants are the most commonly used flame retardants. However, with reports toward adverse effects of flame retardants on human being gradually increasing, more and more attention has been paid to the health risks caused by the use of flame retardants. This chapter introduces the exposure of flame retardants to environment and human, as well as sensitive biomarkers of flame retardants, and emphatically analyzes the toxic effects of flame retardants on health risks including endocrine disruption, neurotoxicity, reproductive inability, immunotoxicity, hepatotoxicity, lung toxicity, carcinogenesis, preterm birth, developmental retardation, and children behavioral problems.

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References

  1. Iqbal M, Syed JH, Katsoyiannis A et al (2017) Legacy and emerging flame retardants (FRs) in the freshwater ecosystem: a review [J]. Environ Res 152:26–42

    CAS  PubMed  Google Scholar 

  2. Cristale J, Katsoyiannis A, Sweetman AJ et al (2013) Occurrence and risk assessment of organophosphorus and brominated flame retardants in the river Aire (UK) [J]. Environ Pollut 179:194–200

    CAS  PubMed  Google Scholar 

  3. Garcia-Lopez M, Rodriguez I, Cela R (2010) Mixed-mode solid-phase extraction followed by liquid chromatography-tandem mass spectrometry for the determination of tri- and di-substituted organophosphorus species in water samples [J]. J Chromatogr A 1217(9):1476–1484

    CAS  PubMed  Google Scholar 

  4. Martinez-Carballo E, Gonzalez-Barreiro C, Sitka A et al (2007) Determination of selected organophosphate esters in the aquatic environment of Austria [J]. Sci Total Environ 388(1–3):290–299

    CAS  PubMed  Google Scholar 

  5. Bogdal C, Schmid P, Kohler M et al (2008) Sediment record and atmospheric deposition of brominated flame retardants and organochlorine compounds in Lake Thun, Switzerland: lessons from the past and evaluation of the present [J]. Environ Sci Technol 42(18):6817–6822

    CAS  PubMed  Google Scholar 

  6. Cristale J, Garcia Vazquez A, Barata C et al (2013) Priority and emerging flame retardants in rivers: occurrence in water and sediment, daphnia magna toxicity and risk assessment [J]. Environ Int 59:232–243

    CAS  PubMed  Google Scholar 

  7. Liu R, Nelson DO, Hurley S et al (2016) Association between serum polybrominated diphenyl ether levels and residential proximity to solid-waste facilities [J]. Environ Sci Technol 50(7):3945–3953

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Luigi V, Giuseppe M, Claudio R (2015) Emerging and priority contaminants with endocrine active potentials in sediments and fish from the River Po (Italy) [J]. Environ Sci Pollut Res Int 22(18):14050–14066

    CAS  PubMed  Google Scholar 

  9. Zhang X, Diamond ML, Robson M et al (2011) Sources, emissions, and fate of polybrominated diphenyl ethers and polychlorinated biphenyls indoors in Toronto, Canada [J]. Environ Sci Technol 45(8):3268–3274

    CAS  PubMed  Google Scholar 

  10. Ni K, Lu Y, Wang T et al (2013) A review of human exposure to polybrominated diphenyl ethers (PBDEs) in China [J]. Int J Hyg Environ Health 216(6):607–623

    CAS  PubMed  Google Scholar 

  11. Hites RA (2004) Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations [J]. Environ Sci Technol 38(4):945–956

    CAS  PubMed  Google Scholar 

  12. Jianxian S, Hui P, Jianying H (2015) Temporal trends of polychlorinated biphenyls, polybrominated diphenyl ethers, and perfluorinated compounds in Chinese sturgeon (Acipenser sinensis) eggs (1984-2008) [J]. Environ Sci Technol 49(3):1621–1630

    PubMed  Google Scholar 

  13. Gabrielsen KM, Krokstad JS, Villanger GD et al (2015) Thyroid hormones and deiodinase activity in plasma and tissues in relation to high levels of organohalogen contaminants in East Greenland polar bears (Ursus maritimus) [J]. Environ Res 136:413–423

    CAS  PubMed  Google Scholar 

  14. Persson S, Magnusson U (2015) Environmental pollutants and alterations in the reproductive system in wild male mink (Neovison vison) from Sweden [J]. Chemosphere 120:237–245

    CAS  PubMed  Google Scholar 

  15. Zhao Y, Song Q, Cao Z et al (2018) Umbilical cord blood PBDEs concentrations in relation to placental size at birth [J]. Chemosphere 201:20–24

    CAS  PubMed  Google Scholar 

  16. Zhang J, Chen L, Xiao L et al (2017) Polybrominated diphenyl ether concentrations in human breast milk specimens worldwide [J]. Epidemiology 28(Suppl 1):S89–s97

    PubMed  Google Scholar 

  17. Chen Y, Wang X, Li Y et al (2015) Persistent organic pollutants in matched breast milk and infant faeces samples [J]. Chemosphere 118:309–314

    CAS  PubMed  Google Scholar 

  18. Zhang X, Zhang K, Yang D et al (2014) Polybrominated biphenyl ethers in breast milk and infant formula from Shanghai, China: temporal trends, daily intake, and risk assessment [J]. Sci Total Environ 497-498:508–515

    CAS  PubMed  Google Scholar 

  19. Shin MY, Lee S, Kim HJ et al (2016) Polybrominated diphenyl ethers in maternal serum, breast milk, umbilical cord serum, and house dust in a south korean birth panel of mother-neonate pairs [J]. Int J Environ Res Public Health 13(8):767

    PubMed Central  Google Scholar 

  20. Guillette LJ Jr, Iguchi T (2012) Ecology. Life in a contaminated world [J]. Science 337(6102):1614–1615

    PubMed  Google Scholar 

  21. Saillenfait AM, Ndaw S, Robert A et al (2018) Recent biomonitoring reports on phosphate ester flame retardants: a short review [J]. Arch Toxicol 92(9):2749–2778

    CAS  PubMed  Google Scholar 

  22. Zhao F, Kang Q, Zhang X et al (2019) Urinary biomarkers for assessment of human exposure to monomeric aryl phosphate flame retardants [J]. Environ Int 124:259–264

    CAS  PubMed  Google Scholar 

  23. Hoffman K, Fang M, Horman B et al (2014) Urinary tetrabromobenzoic acid (TBBA) as a biomarker of exposure to the flame retardant mixture Firemaster(R) 550 [J]. Environ Health Perspect 122(9):963–969

    CAS  PubMed  PubMed Central  Google Scholar 

  24. Bowers WJ, Wall PM, Nakai JS et al (2015) Behavioral and thyroid effects of in utero and lactational exposure of Sprague-Dawley rats to the polybrominated diphenyl ether mixture DE71 [J]. Neurotoxicology and teratology 52(Pt B):127–142

    CAS  PubMed  Google Scholar 

  25. Cao J, Lin Y, Guo LH et al (2010) Structure-based investigation on the binding interaction of hydroxylated polybrominated diphenyl ethers with thyroxine transport proteins [J]. Toxicology 277(1–3):20–28

    CAS  PubMed  Google Scholar 

  26. Lu D, Jin Y, Feng C et al (2017) Multi-analyte method development for analysis of brominated flame retardants (BFRs) and PBDE metabolites in human serum [J]. Anal Bioanal Chem 409(22):5307–5317

    CAS  PubMed  Google Scholar 

  27. Ahmed OM, El-Gareib AW, El-Bakry AM et al (2008) Thyroid hormones states and brain development interactions [J]. Int J Dev Neurosci 26(2):147–209

    CAS  PubMed  Google Scholar 

  28. Boas M, Feldt-Rasmussen U, Skakkebaek NE et al (2006) Environmental chemicals and thyroid function [J]. Eur J Endocrinol 154(5):599–611

    CAS  PubMed  Google Scholar 

  29. Hamers T, Kamstra JH, Sonneveld E et al (2006) In vitro profiling of the endocrine-disrupting potency of brominated flame retardants [J]. Toxicol Sci 92(1):157–173

    CAS  PubMed  Google Scholar 

  30. Gosavi RA, Knudsen GA, Birnbaum LS et al (2013) Mimicking of estradiol binding by flame retardants and their metabolites: a crystallographic analysis [J]. Environ Health Perspect 121(10):1194–1199

    CAS  PubMed  PubMed Central  Google Scholar 

  31. Butt CM, Stapleton HM (2013) Inhibition of thyroid hormone sulfotransferase activity by brominated flame retardants and halogenated phenolics [J]. Chem Res Toxicol 26(11):1692–1702

    CAS  PubMed  Google Scholar 

  32. Patisaul HB, Roberts SC, Mabrey N et al (2013) Accumulation and endocrine disrupting effects of the flame retardant mixture Firemaster(R) 550 in rats: an exploratory assessment [J]. J Biochem Mol Toxicol 27(2):124–136

    CAS  PubMed  Google Scholar 

  33. Hoffman K, Sosa JA, Stapleton HM (2017) Do flame retardant chemicals increase the risk for thyroid dysregulation and cancer? [J]. Curr Opin Oncol 29(1):7–13

    CAS  PubMed  Google Scholar 

  34. Vazzana N, Santilli F, Sestili S et al (2011) Determinants of increased cardiovascular disease in obesity and metabolic syndrome [J]. Curr Med Chem 18(34):5267–5280

    CAS  PubMed  Google Scholar 

  35. Prasad H, Ryan DA, Celzo MF et al (2012) Metabolic syndrome: definition and therapeutic implications [J]. Postgrad Med 124(1):21–30

    PubMed  Google Scholar 

  36. Sherling DH, Perumareddi P, Hennekens CH (2017) Metabolic syndrome [J]. J Cardiovasc Pharmacol Ther 22(4):365–367

    CAS  PubMed  Google Scholar 

  37. Darbre PD (2017) Endocrine disruptors and obesity[J]. Curr Obes Rep 6(1):18–27

    PubMed  PubMed Central  Google Scholar 

  38. Chen X, Huang C, Wang X et al (2012) BDE-47 disrupts axonal growth and motor behavior in developing zebrafish [J]. Aquat Toxicol 120-121:35–44

    CAS  PubMed  Google Scholar 

  39. An J, Li S, Zhong Y et al (2011) The cytotoxic effects of synthetic 6-hydroxylated and 6-methoxylated polybrominated diphenyl ether 47 (BDE47) [J]. Environ Toxicol 26(6):591–599

    CAS  PubMed  Google Scholar 

  40. Kuriyama SN, Talsness CE, Grote K et al (2005) Developmental exposure to low dose PBDE 99: effects on male fertility and neurobehavior in rat offspring [J]. Environ Health Perspect 113(2):149–154

    CAS  PubMed  Google Scholar 

  41. Abdelouahab N, Ainmelk Y, Takser L (2011) Polybrominated diphenyl ethers and sperm quality [J]. Reprod Toxicol 31(4):546–550

    CAS  PubMed  Google Scholar 

  42. Main KM, Kiviranta H, Virtanen HE et al (2007) Flame retardants in placenta and breast milk and cryptorchidism in newborn boys [J]. Environ Health Perspect 115(10):1519–1526

    CAS  PubMed  PubMed Central  Google Scholar 

  43. Chao HR, Shy CG, Wang SL et al (2010) Impact of non-occupational exposure to polybrominated diphenyl ethers on menstruation characteristics of reproductive-age females [J]. Environ Int 36(7):728–735

    CAS  PubMed  Google Scholar 

  44. Li H, Su G, Zou M et al (2015) Effects of tris(1,3-dichloro-2-propyl) phosphate on growth, reproduction, and gene transcription of daphnia magna at environmentally relevant concentrations [J]. Environ Sci Technol 49(21):12975–12983

    CAS  PubMed  Google Scholar 

  45. Ashwood P, Schauer J, Pessah IN et al (2009) Preliminary evidence of the in vitro effects of BDE-47 on innate immune responses in children with autism spectrum disorders [J]. J Neuroimmunol 208(1–2):130–135

    CAS  PubMed  PubMed Central  Google Scholar 

  46. Fernie KJ, Mayne G, Shutt JL et al (2005) Evidence of immunomodulation in nestling American kestrels (Falco sparverius) exposed to environmentally relevant PBDEs [J]. Environ Pollut 138(3):485–493

    CAS  PubMed  Google Scholar 

  47. Saquib Q, Siddiqui MA, Ahmed J et al (2016) Hazards of low dose flame-retardants (BDE-47 and BDE-32): influence on transcriptome regulation and cell death in human liver cells [J]. J Hazard Mater 308:37–49

    CAS  PubMed  Google Scholar 

  48. Araki A, Saito I, Kanazawa A et al (2014) Phosphorus flame retardants in indoor dust and their relation to asthma and allergies of inhabitants [J]. Indoor Air 24(1):3–15

    CAS  PubMed  Google Scholar 

  49. Betts KS (2015) Tracking alternative flame retardants: hand-to-mouth exposures in adults [J]. Environ Health Perspect 123(2):A44

    PubMed  PubMed Central  Google Scholar 

  50. Darnerud PO (2003) Toxic effects of brominated flame retardants in man and in wildlife [J]. Environ Int 29(6):841–853

    CAS  PubMed  Google Scholar 

  51. Hardell L, Carlberg M, Hardell K et al (2007) Decreased survival in pancreatic cancer patients with high concentrations of organochlorines in adipose tissue [J]. Biomed Pharmacother 61(10):659–664

    CAS  PubMed  Google Scholar 

  52. Li ZH, Liu XY, Wang N et al (2012) Effects of decabrominated diphenyl ether (PBDE-209) in regulation of growth and apoptosis of breast, ovarian, and cervical cancer cells [J]. Environ Health Perspect 120(4):541–546

    CAS  PubMed  PubMed Central  Google Scholar 

  53. Hardell L, Lindstrom G, Van Bavel B et al (1998) Concentrations of the flame retardant 2,2′,4,4′-tetrabrominated diphenyl ether in human adipose tissue in swedish persons and the risk for non-Hodgkin's lymphoma[J]. Oncol Res 10(8):429–432

    CAS  PubMed  Google Scholar 

  54. Schreder ED, Uding N, La Guardia MJ (2016) Inhalation a significant exposure route for chlorinated organophosphate flame retardants [J]. Chemosphere 150:499–504

    CAS  PubMed  Google Scholar 

  55. Leonetti C, Butt CM, Hoffman K et al (2016) Brominated flame retardants in placental tissues: associations with infant sex and thyroid hormone endpoints [J]. Environ Health 15(1):113

    PubMed  PubMed Central  Google Scholar 

  56. Zhao Y, Ruan X, Li Y et al (2013) Polybrominated diphenyl ethers (PBDEs) in aborted human fetuses and placental transfer during the first trimester of pregnancy [J]. Environ Sci Technol 47(11):5939–5946

    CAS  PubMed  Google Scholar 

  57. Peltier MR, Koo HC, Getahun D et al (2015) Does exposure to flame retardants increase the risk for preterm birth? [J]. J Reprod Immunol 107:20–25

    CAS  PubMed  Google Scholar 

  58. Behnia F, Peltier MR, Saade GR et al (2015) Environmental pollutant polybrominated diphenyl ether, a flame retardant, induces primary amnion cell senescence [J]. Am J Reprod Immunol 74(5):398–406

    CAS  PubMed  Google Scholar 

  59. Lopez-Espinosa MJ, Costa O, Vizcaino E et al (2015) Prenatal exposure to polybrominated flame retardants and fetal growth in the INMA cohort (Spain) [J]. Environ Sci Technol 49(16):10108–10116

    CAS  PubMed  PubMed Central  Google Scholar 

  60. Zhao Y, Liu P, Wang J et al (2016) Umbilical cord blood PBDEs concentrations are associated with placental DNA methylation [J]. Environ Int 97:1–6

    CAS  PubMed  Google Scholar 

  61. Herbstman JB, Sjodin A, Kurzon M et al (2010) Prenatal exposure to PBDEs and neurodevelopment [J]. Environ Health Perspect 118(5):712–719

    CAS  PubMed  PubMed Central  Google Scholar 

  62. Gascon M, Vrijheid M, Martinez D et al (2011) Effects of pre and postnatal exposure to low levels of polybromodiphenyl ethers on neurodevelopment and thyroid hormone levels at 4 years of age [J]. Environ Int 37(3):605–611

    CAS  PubMed  Google Scholar 

  63. Battle DE (2013) Diagnostic and statistical manual of mental disorders (DSM) [J]. CoDAS 25(2):191–192

    PubMed  Google Scholar 

  64. Braun JM, Kalkbrenner AE, Just AC et al (2014) Gestational exposure to endocrine-disrupting chemicals and reciprocal social, repetitive, and stereotypic behaviors in 4- and 5-year-old children: the HOME study [J]. Environ Health Perspect 122(5):513–520

    CAS  PubMed  PubMed Central  Google Scholar 

  65. Hertz-Picciotto I, Bergman A, Fangstrom B et al (2011) Polybrominated diphenyl ethers in relation to autism and developmental delay: a case-control study [J]. Environ Health 10(1):1

    CAS  PubMed  PubMed Central  Google Scholar 

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Jin, Y., Chen, S. (2019). Flame Retardants: Exposure, Biomarkers, and Health Risks. In: Zhang, Y. (eds) Emerging Chemicals and Human Health. Springer, Singapore. https://doi.org/10.1007/978-981-32-9535-3_8

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