Abstract
Flame retardants have been extensively used in various fields of production and daily life, such as aerospace, transportation, and interior decoration, to ensure fire safety. They are mainly divided into inorganic, halogenated organic, nitrogen-containing, and phosphorus-containing compounds, among which, brominated flame retardants and organophosphorous flame retardants are the most commonly used flame retardants. However, with reports toward adverse effects of flame retardants on human being gradually increasing, more and more attention has been paid to the health risks caused by the use of flame retardants. This chapter introduces the exposure of flame retardants to environment and human, as well as sensitive biomarkers of flame retardants, and emphatically analyzes the toxic effects of flame retardants on health risks including endocrine disruption, neurotoxicity, reproductive inability, immunotoxicity, hepatotoxicity, lung toxicity, carcinogenesis, preterm birth, developmental retardation, and children behavioral problems.
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References
Iqbal M, Syed JH, Katsoyiannis A et al (2017) Legacy and emerging flame retardants (FRs) in the freshwater ecosystem: a review [J]. Environ Res 152:26–42
Cristale J, Katsoyiannis A, Sweetman AJ et al (2013) Occurrence and risk assessment of organophosphorus and brominated flame retardants in the river Aire (UK) [J]. Environ Pollut 179:194–200
Garcia-Lopez M, Rodriguez I, Cela R (2010) Mixed-mode solid-phase extraction followed by liquid chromatography-tandem mass spectrometry for the determination of tri- and di-substituted organophosphorus species in water samples [J]. J Chromatogr A 1217(9):1476–1484
Martinez-Carballo E, Gonzalez-Barreiro C, Sitka A et al (2007) Determination of selected organophosphate esters in the aquatic environment of Austria [J]. Sci Total Environ 388(1–3):290–299
Bogdal C, Schmid P, Kohler M et al (2008) Sediment record and atmospheric deposition of brominated flame retardants and organochlorine compounds in Lake Thun, Switzerland: lessons from the past and evaluation of the present [J]. Environ Sci Technol 42(18):6817–6822
Cristale J, Garcia Vazquez A, Barata C et al (2013) Priority and emerging flame retardants in rivers: occurrence in water and sediment, daphnia magna toxicity and risk assessment [J]. Environ Int 59:232–243
Liu R, Nelson DO, Hurley S et al (2016) Association between serum polybrominated diphenyl ether levels and residential proximity to solid-waste facilities [J]. Environ Sci Technol 50(7):3945–3953
Luigi V, Giuseppe M, Claudio R (2015) Emerging and priority contaminants with endocrine active potentials in sediments and fish from the River Po (Italy) [J]. Environ Sci Pollut Res Int 22(18):14050–14066
Zhang X, Diamond ML, Robson M et al (2011) Sources, emissions, and fate of polybrominated diphenyl ethers and polychlorinated biphenyls indoors in Toronto, Canada [J]. Environ Sci Technol 45(8):3268–3274
Ni K, Lu Y, Wang T et al (2013) A review of human exposure to polybrominated diphenyl ethers (PBDEs) in China [J]. Int J Hyg Environ Health 216(6):607–623
Hites RA (2004) Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations [J]. Environ Sci Technol 38(4):945–956
Jianxian S, Hui P, Jianying H (2015) Temporal trends of polychlorinated biphenyls, polybrominated diphenyl ethers, and perfluorinated compounds in Chinese sturgeon (Acipenser sinensis) eggs (1984-2008) [J]. Environ Sci Technol 49(3):1621–1630
Gabrielsen KM, Krokstad JS, Villanger GD et al (2015) Thyroid hormones and deiodinase activity in plasma and tissues in relation to high levels of organohalogen contaminants in East Greenland polar bears (Ursus maritimus) [J]. Environ Res 136:413–423
Persson S, Magnusson U (2015) Environmental pollutants and alterations in the reproductive system in wild male mink (Neovison vison) from Sweden [J]. Chemosphere 120:237–245
Zhao Y, Song Q, Cao Z et al (2018) Umbilical cord blood PBDEs concentrations in relation to placental size at birth [J]. Chemosphere 201:20–24
Zhang J, Chen L, Xiao L et al (2017) Polybrominated diphenyl ether concentrations in human breast milk specimens worldwide [J]. Epidemiology 28(Suppl 1):S89–s97
Chen Y, Wang X, Li Y et al (2015) Persistent organic pollutants in matched breast milk and infant faeces samples [J]. Chemosphere 118:309–314
Zhang X, Zhang K, Yang D et al (2014) Polybrominated biphenyl ethers in breast milk and infant formula from Shanghai, China: temporal trends, daily intake, and risk assessment [J]. Sci Total Environ 497-498:508–515
Shin MY, Lee S, Kim HJ et al (2016) Polybrominated diphenyl ethers in maternal serum, breast milk, umbilical cord serum, and house dust in a south korean birth panel of mother-neonate pairs [J]. Int J Environ Res Public Health 13(8):767
Guillette LJ Jr, Iguchi T (2012) Ecology. Life in a contaminated world [J]. Science 337(6102):1614–1615
Saillenfait AM, Ndaw S, Robert A et al (2018) Recent biomonitoring reports on phosphate ester flame retardants: a short review [J]. Arch Toxicol 92(9):2749–2778
Zhao F, Kang Q, Zhang X et al (2019) Urinary biomarkers for assessment of human exposure to monomeric aryl phosphate flame retardants [J]. Environ Int 124:259–264
Hoffman K, Fang M, Horman B et al (2014) Urinary tetrabromobenzoic acid (TBBA) as a biomarker of exposure to the flame retardant mixture Firemaster(R) 550 [J]. Environ Health Perspect 122(9):963–969
Bowers WJ, Wall PM, Nakai JS et al (2015) Behavioral and thyroid effects of in utero and lactational exposure of Sprague-Dawley rats to the polybrominated diphenyl ether mixture DE71 [J]. Neurotoxicology and teratology 52(Pt B):127–142
Cao J, Lin Y, Guo LH et al (2010) Structure-based investigation on the binding interaction of hydroxylated polybrominated diphenyl ethers with thyroxine transport proteins [J]. Toxicology 277(1–3):20–28
Lu D, Jin Y, Feng C et al (2017) Multi-analyte method development for analysis of brominated flame retardants (BFRs) and PBDE metabolites in human serum [J]. Anal Bioanal Chem 409(22):5307–5317
Ahmed OM, El-Gareib AW, El-Bakry AM et al (2008) Thyroid hormones states and brain development interactions [J]. Int J Dev Neurosci 26(2):147–209
Boas M, Feldt-Rasmussen U, Skakkebaek NE et al (2006) Environmental chemicals and thyroid function [J]. Eur J Endocrinol 154(5):599–611
Hamers T, Kamstra JH, Sonneveld E et al (2006) In vitro profiling of the endocrine-disrupting potency of brominated flame retardants [J]. Toxicol Sci 92(1):157–173
Gosavi RA, Knudsen GA, Birnbaum LS et al (2013) Mimicking of estradiol binding by flame retardants and their metabolites: a crystallographic analysis [J]. Environ Health Perspect 121(10):1194–1199
Butt CM, Stapleton HM (2013) Inhibition of thyroid hormone sulfotransferase activity by brominated flame retardants and halogenated phenolics [J]. Chem Res Toxicol 26(11):1692–1702
Patisaul HB, Roberts SC, Mabrey N et al (2013) Accumulation and endocrine disrupting effects of the flame retardant mixture Firemaster(R) 550 in rats: an exploratory assessment [J]. J Biochem Mol Toxicol 27(2):124–136
Hoffman K, Sosa JA, Stapleton HM (2017) Do flame retardant chemicals increase the risk for thyroid dysregulation and cancer? [J]. Curr Opin Oncol 29(1):7–13
Vazzana N, Santilli F, Sestili S et al (2011) Determinants of increased cardiovascular disease in obesity and metabolic syndrome [J]. Curr Med Chem 18(34):5267–5280
Prasad H, Ryan DA, Celzo MF et al (2012) Metabolic syndrome: definition and therapeutic implications [J]. Postgrad Med 124(1):21–30
Sherling DH, Perumareddi P, Hennekens CH (2017) Metabolic syndrome [J]. J Cardiovasc Pharmacol Ther 22(4):365–367
Darbre PD (2017) Endocrine disruptors and obesity[J]. Curr Obes Rep 6(1):18–27
Chen X, Huang C, Wang X et al (2012) BDE-47 disrupts axonal growth and motor behavior in developing zebrafish [J]. Aquat Toxicol 120-121:35–44
An J, Li S, Zhong Y et al (2011) The cytotoxic effects of synthetic 6-hydroxylated and 6-methoxylated polybrominated diphenyl ether 47 (BDE47) [J]. Environ Toxicol 26(6):591–599
Kuriyama SN, Talsness CE, Grote K et al (2005) Developmental exposure to low dose PBDE 99: effects on male fertility and neurobehavior in rat offspring [J]. Environ Health Perspect 113(2):149–154
Abdelouahab N, Ainmelk Y, Takser L (2011) Polybrominated diphenyl ethers and sperm quality [J]. Reprod Toxicol 31(4):546–550
Main KM, Kiviranta H, Virtanen HE et al (2007) Flame retardants in placenta and breast milk and cryptorchidism in newborn boys [J]. Environ Health Perspect 115(10):1519–1526
Chao HR, Shy CG, Wang SL et al (2010) Impact of non-occupational exposure to polybrominated diphenyl ethers on menstruation characteristics of reproductive-age females [J]. Environ Int 36(7):728–735
Li H, Su G, Zou M et al (2015) Effects of tris(1,3-dichloro-2-propyl) phosphate on growth, reproduction, and gene transcription of daphnia magna at environmentally relevant concentrations [J]. Environ Sci Technol 49(21):12975–12983
Ashwood P, Schauer J, Pessah IN et al (2009) Preliminary evidence of the in vitro effects of BDE-47 on innate immune responses in children with autism spectrum disorders [J]. J Neuroimmunol 208(1–2):130–135
Fernie KJ, Mayne G, Shutt JL et al (2005) Evidence of immunomodulation in nestling American kestrels (Falco sparverius) exposed to environmentally relevant PBDEs [J]. Environ Pollut 138(3):485–493
Saquib Q, Siddiqui MA, Ahmed J et al (2016) Hazards of low dose flame-retardants (BDE-47 and BDE-32): influence on transcriptome regulation and cell death in human liver cells [J]. J Hazard Mater 308:37–49
Araki A, Saito I, Kanazawa A et al (2014) Phosphorus flame retardants in indoor dust and their relation to asthma and allergies of inhabitants [J]. Indoor Air 24(1):3–15
Betts KS (2015) Tracking alternative flame retardants: hand-to-mouth exposures in adults [J]. Environ Health Perspect 123(2):A44
Darnerud PO (2003) Toxic effects of brominated flame retardants in man and in wildlife [J]. Environ Int 29(6):841–853
Hardell L, Carlberg M, Hardell K et al (2007) Decreased survival in pancreatic cancer patients with high concentrations of organochlorines in adipose tissue [J]. Biomed Pharmacother 61(10):659–664
Li ZH, Liu XY, Wang N et al (2012) Effects of decabrominated diphenyl ether (PBDE-209) in regulation of growth and apoptosis of breast, ovarian, and cervical cancer cells [J]. Environ Health Perspect 120(4):541–546
Hardell L, Lindstrom G, Van Bavel B et al (1998) Concentrations of the flame retardant 2,2′,4,4′-tetrabrominated diphenyl ether in human adipose tissue in swedish persons and the risk for non-Hodgkin's lymphoma[J]. Oncol Res 10(8):429–432
Schreder ED, Uding N, La Guardia MJ (2016) Inhalation a significant exposure route for chlorinated organophosphate flame retardants [J]. Chemosphere 150:499–504
Leonetti C, Butt CM, Hoffman K et al (2016) Brominated flame retardants in placental tissues: associations with infant sex and thyroid hormone endpoints [J]. Environ Health 15(1):113
Zhao Y, Ruan X, Li Y et al (2013) Polybrominated diphenyl ethers (PBDEs) in aborted human fetuses and placental transfer during the first trimester of pregnancy [J]. Environ Sci Technol 47(11):5939–5946
Peltier MR, Koo HC, Getahun D et al (2015) Does exposure to flame retardants increase the risk for preterm birth? [J]. J Reprod Immunol 107:20–25
Behnia F, Peltier MR, Saade GR et al (2015) Environmental pollutant polybrominated diphenyl ether, a flame retardant, induces primary amnion cell senescence [J]. Am J Reprod Immunol 74(5):398–406
Lopez-Espinosa MJ, Costa O, Vizcaino E et al (2015) Prenatal exposure to polybrominated flame retardants and fetal growth in the INMA cohort (Spain) [J]. Environ Sci Technol 49(16):10108–10116
Zhao Y, Liu P, Wang J et al (2016) Umbilical cord blood PBDEs concentrations are associated with placental DNA methylation [J]. Environ Int 97:1–6
Herbstman JB, Sjodin A, Kurzon M et al (2010) Prenatal exposure to PBDEs and neurodevelopment [J]. Environ Health Perspect 118(5):712–719
Gascon M, Vrijheid M, Martinez D et al (2011) Effects of pre and postnatal exposure to low levels of polybromodiphenyl ethers on neurodevelopment and thyroid hormone levels at 4 years of age [J]. Environ Int 37(3):605–611
Battle DE (2013) Diagnostic and statistical manual of mental disorders (DSM) [J]. CoDAS 25(2):191–192
Braun JM, Kalkbrenner AE, Just AC et al (2014) Gestational exposure to endocrine-disrupting chemicals and reciprocal social, repetitive, and stereotypic behaviors in 4- and 5-year-old children: the HOME study [J]. Environ Health Perspect 122(5):513–520
Hertz-Picciotto I, Bergman A, Fangstrom B et al (2011) Polybrominated diphenyl ethers in relation to autism and developmental delay: a case-control study [J]. Environ Health 10(1):1
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Jin, Y., Chen, S. (2019). Flame Retardants: Exposure, Biomarkers, and Health Risks. In: Zhang, Y. (eds) Emerging Chemicals and Human Health. Springer, Singapore. https://doi.org/10.1007/978-981-32-9535-3_8
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DOI: https://doi.org/10.1007/978-981-32-9535-3_8
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