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Pesticides: Environmental Exposure, Toxicity, and Mechanism

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Emerging Chemicals and Human Health
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Abstract

Pesticides are substances that are meant to control pests or weeds. The production and use of synthetic pesticides have been increasingly growing in recent years worldwide. Pesticides are designed to be toxic to specific groups of organisms, which bring benefits to humans. However, they have considerable adverse effects on other living creatures as well as environmental media including air, water, and soil. Pesticides can enter the human body via the skin, the mouth, and the lungs, thereby leading to diverse toxicity actions on humans. This chapter provides a brief overview of classification, toxicity, health effects, and environmental exposure of pesticides, as well as toxicity and mechanism of three major pesticides (organophosphorus, pyrethroid, and carbamate pesticides).

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References

  1. Marrs TC, Ballantyne B (2004) Pesticide toxicology and international regulation [M]. Wiley, Chichester

    Google Scholar 

  2. Damalas C, Koutroubas S (2016) Farmers’ exposure to pesticides: toxicity types and ways of prevention [J]. Toxics 4(1):1

    Article  PubMed Central  Google Scholar 

  3. Mostafalou S, Abdollahi M (2017) Pesticides: an update of human exposure and toxicity [J]. Arch Toxicol 91(2):549–599

    Article  CAS  PubMed  Google Scholar 

  4. Patel S, Sangeeta S (2019) Pesticides as the drivers of neuropsychotic diseases, cancers, and teratogenicity among agro-workers as well as general public [J]. Environ Sci Pollut Res 26(1):91–100

    Article  CAS  Google Scholar 

  5. Kim K, Kabir E, Jahan SA (2017) Exposure to pesticides and the associated human health effects [J]. Sci Total Environ 575:525–535

    Article  CAS  PubMed  Google Scholar 

  6. Simeonov LI, Macaev FZ, Simeonova BG (2013) Environmental security assessment and management of obsolete pesticides in Southeast Europe [M]. Springer, Dordrecht

    Book  Google Scholar 

  7. Colovic MB, Krstic DZ, Lazarevic-Pasti TD et al (2013) Acetylcholinesterase inhibitors: pharmacology and toxicology [J]. Curr Neuropharmacol 11(3):315–335

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Mileson BE, Chambers JE, Chen WL et al (1998) Common mechanism of toxicity: a case study of organophosphorus pesticides [J]. Toxicol Sci 41(1):8–20

    CAS  PubMed  Google Scholar 

  9. Mostafalou S, Abdollahi M (2018) The link of organophosphorus pesticides with neurodegenerative and neurodevelopmental diseases based on evidence and mechanisms [J]. Toxicology 409:44–52

    Article  CAS  PubMed  Google Scholar 

  10. Joshi P, Manoria P, Joseph D et al (2013) Acute myocardial infarction: can it be a complication of acute organophosphorus compound poisoning? [J]. J Postgrad Med 59(2):142–144

    Article  CAS  PubMed  Google Scholar 

  11. Costa LG (2018) Organophosphorus compounds at 80: some old and new issues [J]. Toxicol Sci 162(1):24–35

    Article  CAS  PubMed  Google Scholar 

  12. Jokanović M, Kosanović M, Brkić D et al (2011) Organophosphate induced delayed polyneuropathy in man: an overview [J]. Clin Neurol Neurosurg 113(1):7–10

    Article  PubMed  Google Scholar 

  13. Akçay Yalbuzdag Ş (2017) Organophosphate induced delayed neuropathy: a case report [J]. Türk Fiz Tıp Rehab Derg 63(1):88–91

    Google Scholar 

  14. Haliga RE, Morarasu BC, Ursaru M et al (2018) New insights into the organophosphate-induced intermediate syndrome [J]. Arch Ind Hyg Toxicol 69(2):191–195

    CAS  Google Scholar 

  15. Xia S. Pesticide toxicology [M]. Chemical Industry Press, Beijing

    Google Scholar 

  16. Miranda-Contreras L, Gomez-Perez R, Rojas G et al (2013) Occupational exposure to organophosphate and carbamate pesticides affects sperm chromatin integrity and reproductive hormone levels among Venezuelan farm workers [J]. J Occup Health 55(3):195–203

    Article  CAS  PubMed  Google Scholar 

  17. Recio-Vega R, Carnpo-Gomez G, Borja-Aburto VH et al (2008) Organophosphorus pesticide exposure decreases sperm quality: association between sperm parameters and urinary pesticide levels [J]. J Appl Toxicol 28(5):674–680

    Article  CAS  PubMed  Google Scholar 

  18. Butler-Dawson J, Galvin K, Thorne PS et al (2016) Organophosphorus pesticide exposure and neurobehavioral performance in Latino children living in an orchard community [J]. Neuro Toxicol 53:165–172

    CAS  Google Scholar 

  19. Abreu-Villaça Y, Levin ED (2017) Developmental neurotoxicity of succeeding generations of insecticides [J]. Environ Int 99:55–77

    Article  PubMed  CAS  Google Scholar 

  20. Zhang Y, Yang Z, Xie F et al (2014) Research advance of OPs neural development toxicity mechanism [J]. J Anhui Agric Sci 42(12):3561–3564

    CAS  Google Scholar 

  21. Timoroğlu İ, Yüzbaşıoğlu D, Ünal F et al (2014) Assessment of the genotoxic effects of organophosphorus insecticides phorate and trichlorfon in human lymphocytes [J]. Environ Toxicol 29(5):577–587

    Article  PubMed  CAS  Google Scholar 

  22. Soderlund DM, Clark JM, Sheets LP et al (2002) Mechanisms of pyrethroid neurotoxicity: implications for cumulative risk assessment [J]. Toxicology 171(1):3–59

    Article  CAS  PubMed  Google Scholar 

  23. Soderlund DM (2012) Molecular mechanisms of pyrethroid insecticide neurotoxicity: recent advances [J]. Arch Toxicol 86(2):165–181

    Article  CAS  PubMed  Google Scholar 

  24. Saillenfait A, Ndiaye D, Sabaté J (2015) Pyrethroids: exposure and health effects – an update [J]. Int J Hyg Environ Health 218(3):281–292

    Article  CAS  PubMed  Google Scholar 

  25. Laugeray A, Herzine A, Perche O et al (2017) In utero and lactational exposure to low-doses of the pyrethroid insecticide cypermethrin leads to neurodevelopmental defects in male mice—an ethological and transcriptomic study [J]. PLoS One 12(10):e184475

    Article  CAS  Google Scholar 

  26. Shafer TJ, Meyer DA, Crofton KM (2005) Developmental neurotoxicity of pyrethroid insecticides: critical review and future research needs [J]. Environ Health Perspect 113(2):123–136

    Article  CAS  PubMed  Google Scholar 

  27. Li Q, Kobayashi M, Kawada T (2015) Carbamate pesticide-induced apoptosis in human T lymphocytes [J]. Int J Environ Res Public Health 12(4):3633–3645

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Li Q, Kobayashi M, Kawada T (2014) Carbamate pesticide-induced apoptosis and necrosis in human natural killer cells [J]. J Biol Regul Homeost Agents 28(1):23–32

    PubMed  Google Scholar 

  29. Rowe C, Gunier R, Bradman A et al (2016) Residential proximity to organophosphate and carbamate pesticide use during pregnancy, poverty during childhood, and cognitive functioning in 10-year-old children [J]. Environ Res 150:128–137

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Popovska-Gorevski M, Dubocovich ML, Rajnarayanan RV (2016) Carbamate insecticides target human melatonin receptors [J]. Chem Res Toxicol 30(2):574–582

    Article  CAS  Google Scholar 

  31. Soloneski S, Kujawski M, Scuto A et al (2015) Carbamates: a study on genotoxic, cytotoxic, and apoptotic effects induced in Chinese hamster ovary (CHO-K1) cells [J]. Toxicol In Vitro 29(5):834–844

    Article  CAS  PubMed  Google Scholar 

  32. Piel C, Pouchieu C, Migault L et al (2018) Increased risk of central nervous system tumours with carbamate insecticide use in the prospective cohort AGRICAN [J]. Int J Epidemiol 48:512–526

    Article  Google Scholar 

  33. Dhouib I, Jallouli M, Annabi A et al (2016) From immunotoxicity to carcinogenicity: the effects of carbamate pesticides on the immune system [J]. Environ Sci Pollut Res 23(10):9448–9458

    Article  CAS  Google Scholar 

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Correspondence to Chunhua Wu .

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Luo, R., Wu, C. (2019). Pesticides: Environmental Exposure, Toxicity, and Mechanism. In: Zhang, Y. (eds) Emerging Chemicals and Human Health. Springer, Singapore. https://doi.org/10.1007/978-981-32-9535-3_7

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