Abstract
Antibiotics have long been used to combat human and animal diseases and promote the growth of livestock. Due to the low metabolic rate of antibiotics, they cannot be fully absorbed by human and animal bodies. Most antibiotics are discharged into the environment in the form of active ingredients or metabolites, resulting in residues in the environmental medium. More and more attention has been paid to the environmental pollution caused by unreasonable and irregular use of antibiotics. Antibiotics in the environment could cause different degrees of toxic effects on various environmental media such as water and soil, and even induce the production of resistance genes, which will bring serious threats to human life and health. This chapter introduces the exposure of antibiotics and their effects on ecological environment and human health. Moreover, we focus on the state-of-art researches on antibiotic resistance gene and initiate several prospects of future research.
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Abbreviations
- Al:
-
aluminum
- ANOVA:
-
analysis of variance
- ANS:
-
autonomic nervous system
- As:
-
arsenic
- Ba:
-
Barium
- BMI:
-
body mass index
- BP:
-
blood pressure
- Br:
-
bromine
- Ca:
-
calcium
- Cd:
-
cadmium
- Cl:
-
chlorine
- Co:
-
Cobalt
- Cr:
-
chromium
- Cu:
-
copper
- DBP:
-
diastolic blood pressure
- ED-XRF:
-
energy dispersive X-ray fluorescence
- ET-1:
-
endothelin-1
- Fe:
-
iron
- GWG:
-
gestational weight gain
- HDP:
-
hypertensive disorders of pregnancy
- ICAM-1:
-
intercellular adhesion molecule 1
- IL:
-
interleukin
- IQR:
-
interquartile range
- K:
-
potassium
- MAP:
-
mean arterial pressure
- Mg:
-
magnesium
- Mn:
-
manganese
- Mo:
-
molybdenum
- mPEAK:
-
Maternal Psychological and Environmental Assessment of Kids
- Na:
-
sodium
- Ni:
-
nickel
- P:
-
phosphorus
- Pb:
-
lead
- PM:
-
particulate matter
- PTFE:
-
polytetrafluoroethylene
- Rb:
-
rubidium
- S:
-
sulfur
- Sb:
-
antimony
- SBP:
-
systolic blood pressure
- Se:
-
selenium
- Si:
-
silicon
- Sn:
-
stannum
- Sr:
-
strontium
- Ti:
-
titanium
- TNFa:
-
tumor necrosis factor alpha
- V:
-
vanadium
- VCIM-1:
-
vascular cell adhesion molecule 1
- Zn:
-
zinc
References
Brandt KK, Amézquita A, Backhaus T et al (2015) Ecotoxicological assessment of antibiotics: a call for improved consideration of microorganisms [J]. Environ Int 85:189–205
Halling Sorensen B, Nielsen SN, Lanzky PF et al (1998) Occurrence, fate and effects of pharmaceutical substances in the environment: a review [J]. Chemosphere 36(2):357–394
Puckowski A, Mioduszewska K, Lukaszewicz P et al (2016) Bioaccumulation and analytics of pharmaceutical residues in the environment: a review [J]. J Pharm Biomed Anal 127:232–255
Chee Sanford JC, Mackie RI, Koike S et al (2009) Fate and transport of antibiotic residues and antibiotic resistance genes following land application of manure waste [J]. J Environ Qual 38(3):1086–1108
Xu Yonggang, Yu Wantai, Ma Qiang et al (2015) The antibiotic in environment and its ecotoxicity: a review [J]. Asian J Ecotoxicol 3:11–27
Du LF, Liu WK (2012) Occurrence, fate and ecotoxicity of antibiotics in agro-ecosystems: a review [J]. Agron Sustain Dev 32(2):309–327
Wellington EMH, Boxall ABA, Cross P et al (2013) The role of the natural environment in the emergence of antibiotic resistance in Gram-negative bacteria [J]. Lancet Infect Dis 13(2):155–165
MartÃnez Carballo E, González Barreiro C, Scharf S et al (2007) Environmental monitoring study of selected veterinary antibiotics in animal manure and soils in Austria [J]. Environ Pollut 148(2):570–579
Carvalho IT, Santos L (2016) Antibiotics in the aquatic environments: a review of the European scenario [J]. Environ Int 94:736–757
Sarmah AK, Meyer MT, Boxall ABA (2006) A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment [J]. Chemosphere 65(5):725–759
Kümmerer K (2009) Antibiotics in the aquatic environment: a review [J]. Chemosphere 75(4):417–434
Lee YJ, Lee SE, Lee DS et al (2008) Risk assessment of human antibiotics in Korean aquatic environment [J]. Environ Toxicol Pharmacol 26(2):216–221
Zounkova R, Kliemesova Z, Nepejchalova L et al (2011) Complex evaluation of ecotoxicity and genotoxicity of antimicrobials oxytetracycline and flumequine used in aquaculture [J]. Environ Toxicol Chem 30(5):1184–1189
Zhang zhenghai. Three major changes of antibiotics in China in the past 10 years, with the output and export volume ranking first in the world [N]. Pharm News. 2010-02-02
Bruce JR, Paul KSL, Michael M (2005) Emerging chemicals of concern: Pharmaceuticals and personal care products (PPCPs) in Asia, with particular reference to Southern China [J]. Mar Pollut Bull 50:913–920
Yu jie, hong tao. The glory and hardship in the era of antibiotics [N]. China Educ Daily. 2003-09-12
People’s Daily online. The misuse of antibiotics may cause the virus mutation [R/OL]. [2003-06-15]. http://www.people.com.cn/GB/paper1787/9423/872497.html. Accessed 5 May 2019
Wu X, Wei Y, Zheng J et al (2011) The behavior of tetracycline and their degradation products during swine manure composting [J]. Bioresour Technol 102(10):5924–5931
Ye BX, Zhang L (2015) Analysis of the pollution status and health risk of antibiotics in water environment and drinking water [J]. Int J Environ Res Public Health 32(2):173–178
Chen T (2010) Research on a variety of antibiotics of wastewater treatment plants in Guangzhou and Zhuhai by HPLC/LC-MS analysis method [D]. Jinan University, Guangzhou
Sacher F, Lange FT, Brauch H (2001) Pharmaceuticals in groundwater: analytical methods and result of a monitoring program in Baden Wurttemberg, Germany [J]. J Chromatogr A 938(1):199–210
Tong L, Li P, Wang YX et al (2009) Analysis of veterinary antibiotic residues in swine wastewater and environmental water samples using optimized SPELC/MS/MS [J]. Chemosphere 74(8):1090–1097
Sun GD, Su ZY, Chen M et al (2009) Simultaneous determination of tetracycline and quinolone antibiotics in environmental water samples using solid phase extraction-ultra pressure liquid chromatography coupled with tandem mass spectrometry [J]. Chin J Chromatogr 27(4):54–58
Golet EM, Alder AC, Hartmann A et al (2001) Trace determination of fluoroquinolone antibacterial agents in solid-phase extraction urban wastewater by and liquid chromatography with fluorescence detection [J]. Anal Chem 73(15):3632–3638
Ma Y, Chen ZZ, Zeng ZL (2007) Effects of enoxacin on soil microbial community functional diversity [J]. Acta Ecol Sin 27(8):3400–3406
Zhang JQ, Dong YH, An Q et al (2005) Behavior of veterinary antibiotics in soil environment [J]. Soil 37(4):353–361
Aust MO, Godlinski F, Travis GR et al (2008) Distribution of sulfamethazine, chlortetracycline and tylosin in manure and soil of Canadian feedlots after sub therapeutic use in cattle [J]. Environ Pollut 156(3):1243–1251
Zhou QX, Luo Y, Wang ME (2007) Environmental residues, ecotoxicity and resistance gene contamination of antibiotics [J]. J Ecotoxicol 2(3):243–251
Tai Yiping (2010) Study on the characteristics of typical antibiotic contamination in soil of vegetable bases in the Pearl River delta region [D]. Jinan university, Guangzhou
Wu Xiaolian (2011) Contamination characteristics and health risks of quinolones antibiotics in vegetables in the Pearl River delta region [D]. Jinan University, Guangzhou
Lillenberg M, Litvin SV, Nei L et al (2010) Enrofloxacin and ciprofloxacin uptake by plants from soil [J]. Agron Res 8(1):807–814
Richardson BJ, Lam PKS, Martin M (2005) Emerging chemicals of concern: pharmaceuticals and personal care products (PPCPs) in Asia, with particular reference to southern China [J]. Mar Pollut Bull 50:913–920
Yu Daojin, Zeng Zhenling, Chen Jaoshi (2005) Effects of oxytetracycline residues on the resistance of sediment bacteria [C]. In: Proceedings of the fourth national conference of the Chinese society of toxicology. Chinese Society of Toxicology, Shenyang, p 1
Wang Penghua, Yuan tao, Tan youming (2008) Effects of drug pollution on aquatic organisms and human health [J]. J Environ Health 25(2):172–174
Gbel A, Thomsen A, McArdell CS et al (2005) Occurrence and sorption behavior of sulfonamides, macrolides, and trimethoprim in activated sludge treatment [J]. Environ Sci Technol 39(11):3981–3989
Jiang L, Lin Z, Hu X et al (2010) Toxicity prediction of antibiotics on luminescent bacteria, Photobacterium phosphoreum, based on their quantitative structure-activity relationship models [J]. Bull Environ Contam Toxicol 85(6):550–555
Hammesfahr U, Heuer H, Manzke B et al (2008) Impact of the antibiotic sulfadiazine and pig manure on the microbial community structure in agricultural soils [J]. Soil Biol Biochem 40(7):1583–1591
Liu Yan, Zhang Zhenhua, Bao Wangbo et al (2016) Effect of penicillin on soil microbial community structure [J]. J Ecol Rural Environ 2:309–314
Van Dijck P, vande Voorde H (1976) Sensitivity of environmental microorganisms to antimicrobial agents [J]. Appl Environ Microbiol 31(3):332–336
Migliore L, Civitareale C, Cozzolino S et al (1998) Laboratory models to evaluate phytotoxicity of sulphadimethoxine on terrestrial plants [J]. Chemosphere 37(14/15):2957–2961
Kumar K, Gupta SC, Baidoo SK et al (2005) Antibiotic uptake by plants from soil fertilized with animal manure [J]. J Environ Qual 34(6):2082–2085
Bao Chenyan, Gu Guoping, Zhang Mingkui (2016) Effect of veterinary antibiotics stress on growth and antibiotics accumulation of Oenanthe javanica DC [J]. Chin J Soil Sci 1:164–172
Kong Wei Dong, Zhu Yong Guan (2007) A review on ecotoxicology of veterinary pharmaceuticals to plants and soil microbes [J]. Asian J Ecotoxicol 1:1–9
Kong WD, Zhu YG, Liang YC et al (2007) Uptake of oxytetracycline and its phytotoxicity to alfalfa [J]. Environ Pollut 147(1):187–193
Zhang Jixu, Shen Guoming, Kong Fanyu et al (2017) Effect of tetracyline on the growth and photosynthesis of flue-cured tobacco [J]. J Agro Environ Sci 1:48–56
Dong L, Gao J, Xie X et al (2012) DNA damage and biochemical toxicity of antibiotics in soil on the earthworm Eisenia fetida [J]. Chemosphere 89(1):44–51
Gao M, Lyu M, Han M et al (2016) Avoidance behavior of Eisenia fetida in oxytetracycline and heavy metal-contaminated soils [J]. Environ Toxicol Pharmacol 47:119–123
Pruden APRT, Storteboom H, Carlson KH (2006) Antibiotic resistance genes as emerging contaminants: studies in Northern Colorado [J]. Environ Sci Technol 40:7445–7450
Henriques IS, Fonseca F, Alves A et al (2006) Occurrence and diversity of integrons and β-lactamase genes among ampicillin-resistant isolates from estuarine waters [J]. Res Microbiol 157(10):938–947
Hsu JT, Chen CY, Young CW et al (2014) Prevalence of sulfonamide-resistant bacteria, resistance genes and integron-associated horizontal gene transfer in natural water bodies and soils adjacent to a swine feedlot in northern Taiwan [J]. J Hazard Mater 277:34–43
Zhang Lanhe, Wang jiajia, Ha xuejiao et al (2016) Distribution characteristics of antibiotic resistance genes in vegetable field soil in Beijing [J]. Environ Sci 11:4395–4401
Cizmas L, Sharma VK, Gray CM et al (2015) Pharmaceuticals and personal care products in waters: occurrence, toxicity and risk [J]. Environ Chem Lett 13(4):381–394
Chen qiuying, Jin caixia, Lu shanhua et al (2008) Research progress on veterinary drug residues and their impact on ecological environment [J]. Anhui Agric Sci 36(16):6943–6952
Lu mei, Gao xiang, Li Shuwen (2008) Determination of tetracycline antibiotic residues in aquatic products by high performance liquid chromatography [J]. Environ Monit Manage Technol 20(5):38–39
Kümmerer K (2009) Antibiotics in the aquatic environment. A review part I [J]. Chemosphere 75(4):417–434
General office of the ministry of health. Notice about on the management of clinical application of antibacterial drugs [EB/OL]. http://www.moh.gov.cn/mohbgt/s9508/200903/39723. Accessed 5 May 2019
Benbrook CM (2002) Antibiotic drug use in U.S. aquaculture [EB/OL]. http://www.iatp.org/library/antibiotics. Accessed 5 May 2019
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Zhao, Y., Xiao, X. (2019). Environmental Antibiotics: Exposure Monitoring and Health Endpoints. In: Zhang, Y. (eds) Emerging Chemicals and Human Health. Springer, Singapore. https://doi.org/10.1007/978-981-32-9535-3_10
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DOI: https://doi.org/10.1007/978-981-32-9535-3_10
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